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PF 4800567 - ≥98%, high purity , CAS No.1188296-52-7, Inhibitor of casein kinase 1 delta;Inhibitor of casein kinase 1 epsilon
a selective inhibitor of casein kinase 1ε
Basic Description Synonyms GEE72DRC63 | BRD-K43428468-003-01-6 | 3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin- 4-amine | PF 4800567 | HMS3740I03 | Sodium 1-(1'-naphthylazo)naphth-2-ol-3,6-disulphonate | BCP28458 | PF-480 | Q7119049 | 3-(3-chl Specifications & Purity Moligand™, ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of casein kinase 1 delta;Inhibitor of casein kinase 1 epsilon Product Description PF 4800567 is a selective casein kinase 1ε inhibitor. PF 4800567 displays a 22-fold greater potency towards CK1ε than CK1δ (IC|50|values are 32 and 711 nM for CK1ε and CK1δ respectively).
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 3-[(3-chlorophenoxy)methyl]-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine INCHI InChI=1S/C17H18ClN5O2/c18-11-2-1-3-13(8-11)25-9-14-15-16(19)20-10-21-17(15)23(22-14)12-4-6-24-7-5-12/h1-3,8,10,12H,4-7,9H2,(H2,19,20,21) InChi Key AUMDBEHGJRZSOO-UHFFFAOYSA-N Canonical SMILES C1COCCC1N2C3=NC=NC(=C3C(=N2)COC4=CC(=CC=C4)Cl)N Isomeric SMILES C1COCCC1N2C3=NC=NC(=C3C(=N2)COC4=CC(=CC=C4)Cl)N PubChem CID 53472153 Molecular Weight 359.81
Chemical and Physical Properties Solubility Soluble in DMSO (100 mM).
References 1. Walton KM, Fisher K, Rubitski D, Marconi M, Meng QJ, Sládek M, Adams J, Bass M, Chandrasekaran R, Butler T et al. . (2009) Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period.. J Pharmacol Exp Ther, 330 (2): (430-9). [PMID:19458106 ] [10.1021/op500134e ]
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J2318384