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PF-4981517 - 98%, high purity , CAS No.1390637-82-7
Selective CYP3A4 inhibitor
Basic Description
| Synonyms | DTXSID60747404 | PF 04981517 | PF-04981517 | (S)-1-methyl-3-(1-methyl-5-(p-tolyl)-1H-pyrazol-4-yl)-4-(3-(piperidin-1-yl)pyrrolidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine | 1-Methyl-3-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-4-[(3S)-3-piperidin-1-ylpyrrol |
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| Specifications & Purity | ≥98% |
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| Biochemical and Physiological Mechanisms | Potent and selective inhibitor of CYP3A4 (IC50values are 0.03, 17 and 70μM for CYP3A4, CYP3A5 and CYP3A7 respectively). |
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| Storage Temp | Store at -20°C |
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| Shipped In | Ice chest + Ice pads |
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| Pubchem Sid | 488202234 |
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| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488202234 |
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| IUPAC Name | 1-methyl-3-[1-methyl-5-(4-methylphenyl)pyrazol-4-yl]-4-[(3S)-3-piperidin-1-ylpyrrolidin-1-yl]pyrazolo[3,4-d]pyrimidine |
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| INCHI | InChI=1S/C26H32N8/c1-18-7-9-19(10-8-18)24-21(15-29-31(24)2)23-22-25(32(3)30-23)27-17-28-26(22)34-14-11-20(16-34)33-12-5-4-6-13-33/h7-10,15,17,20H,4-6,11-14,16H2,1-3H3/t20-/m0/s1 |
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| InChi Key | WDWIMDKOXZZYHH-FQEVSTJZSA-N |
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| Canonical SMILES | CC1=CC=C(C=C1)C2=C(C=NN2C)C3=NN(C4=C3C(=NC=N4)N5CCC(C5)N6CCCCC6)C |
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| Isomeric SMILES | CC1=CC=C(C=C1)C2=C(C=NN2C)C3=NN(C4=C3C(=NC=N4)N5CC[C@@H](C5)N6CCCCC6)C |
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| PubChem CID | 71315139 |
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| Molecular Weight | 456.59 |
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Chemical and Physical Properties
| Solubility | Solvent:DMSO, Max Conc. mg/mL: 45.66, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 9.13, Max Conc. mM: 20 |
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D2318771