PF-562271 - ≥98%, high purity , CAS No.717907-75-0, Inhibitor of aurora kinase A;Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of protein tyrosine kinase 2;Inhibitor of protein tyrosine kinase 2 beta
PF-562271 - ≥98%, high purity , CAS No.717907-75-0, Inhibitor of aurora kinase A;Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of protein tyrosine kinase 2;Inhibitor of protein tyrosine kinase 2 beta
PF-562271|717907-75-0|PF-00562271 free base|PF-562271 free base|PF562271|PF 562271|CHEMBL1084546|N-METHYL-N-[3-[[[2-[(2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL)AMINO]-5-TRIFLUOROMETHYLPYRIMIDIN-4-YL]AMINO]METHYL]PYRIDIN-2-YL]METHANESULFONAMIDE|717907-75-0 (free bas
Specifications & Purity
Moligand™, ≥98%
Biochemical and Physiological Mechanisms
PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC50 of 1.5 and 14 nmol/L, respectively.Potent, selective ATP-competitive, reversible FAK Inhibitor (IC 50 values are 1.5, 13, 30, 47 and 58 nM for FAK,
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of aurora kinase A;Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of protein tyrosine kinase 2;Inhibitor of protein tyrosine kinase 2 beta
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs
1.Roberts WG, Ung E, Whalen P, Cooper B, Hulford C, Autry C, Richter D, Emerson E, Lin J, Kath J et al.. (2008) Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271.. Cancer Res, 68 (6):(1935-44). [PMID:18339875]
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