PF-6260933 (PF-06260933) is a potent inhibitor of MAP4K4 with an IC50 of 3.7 nM, possessing excellent kinome selectivity.
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
Product Description
Information
PF-6260933 PF-6260933 (PF-06260933) is a potent inhibitor of MAP4K4 with an IC50 of 3.7 nM, possessing excellent kinome selectivity.
Targets
MAP4K4 3.7 nM
In vitro
PF-6260933 demonstrates good physicochemical properties as well as moderate human liver microsomal (HLM) clearance.
In vivo
Following oral dosing (10 mg/kg), PF-6260933 displays a plasma exposure that provided free drug concentrations above the cell IC50 value for about 4-6 h after administration in a mouse model. PF-6260933 has suitable PK properties in mouse to be used as a tool in an in vivo model of diabetes.
Product Properties
ALogP
2.815
HBD Count
2
Rotatable Bond
2
Associated Targets(Human)
TNIKTchemTRAF2 and NCK-interacting protein kinase (1 Activities)
