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PF 6274484 - ≥98%(HPLC), high purity , CAS No.1035638-91-5

≥98%(HPLC)

CAS#: 1035638-91-5
Formula: C₁₈H₁₄ClFN₄O₂
Molecular Weight: 372.78
PubChem CID: 74766099

Item Number

P288199

Grouped product items
SKU	Size	Availability	Price
P288199-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$112.90
P288199-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$444.90
P288199-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$2,002.90

High affinity and potent covalent EGFR kinase inhibitor

Basic Description

Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	High affinity and potent covalent EGFR kinase inhibitor (Ki= 0.14 nM). Inhibits autophosphorylation of WT and mutant EGFR in tumor cells (IC50values are 5.8 and 6.6 nM, respectively).
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	PF 6274484 is a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM. PF 6274484 inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and 6.6 nM, respectively.

Associated Targets(Human)

ERBB3 Tclin Receptor tyrosine-protein kinase erbB-3 (1 Activities)

Discover Target: ERBB3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EGFR Tclin Epidermal growth factor receptor (4 Activities)

Discover Target: EGFR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)

Discover Target: EGFR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ERBB3 Tclin Receptor tyrosine-protein kinase erbB-3 (297 Activities)

Discover Target: ERBB3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DUS2 Tbio tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (1 Activities)

Discover Target: DUS2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]prop-2-enamide
INCHI	InChI=1S/C18H14ClFN4O2/c1-3-17(25)24-15-7-11-14(8-16(15)26-2)21-9-22-18(11)23-10-4-5-13(20)12(19)6-10/h3-9H,1H2,2H3,(H,24,25)(H,21,22,23)
InChi Key	TUYDDIWQXWTNSW-UHFFFAOYSA-N
Canonical SMILES	COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)C=C
Isomeric SMILES	COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)C=C
PubChem CID	74766099
Molecular Weight	372.78

Certificates

Certificate of Analysis(COA)

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3 results found

Lot Number	Certificate Type	Date	Item
K2101094	Certificate of Analysis	Aug 19, 2024	P288199
K2101095	Certificate of Analysis	Aug 19, 2024	P288199
K2101097	Certificate of Analysis	Aug 19, 2024	P288199

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PF 6274484 - ≥98%(HPLC), high purity , CAS No.1035638-91-5

Basic Description

Associated Targets(Human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

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