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PFI 4 - 97%, high purity , CAS No.900305-37-5, bromodomain and PHD finger containing 1
Potent and selective BRPF1B bromodomain inhibitor
Basic Description Synonyms N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide Specifications & Purity Moligand™, ≥97% Biochemical and Physiological Mechanisms Potent and selective BRPF1B bromodomain inhibitor (IC50= 172 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4. Disrupts BRPF1 binding to histone H3.3. Cell permeable. Inhibits osteocla Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Mechanism of action bromodomain and PHD finger containing 1
Names and Identifiers IUPAC Name N-(1,3-dimethyl-2-oxo-6-pyrrolidin-1-ylbenzimidazol-5-yl)-2-methoxybenzamide INCHI InChI=1S/C21H24N4O3/c1-23-17-12-15(22-20(26)14-8-4-5-9-19(14)28-3)16(25-10-6-7-11-25)13-18(17)24(2)21(23)27/h4-5,8-9,12-13H,6-7,10-11H2,1-3H3,(H,22,26) InChi Key QCIJLRJBZDBVDB-UHFFFAOYSA-N Canonical SMILES CN1C2=C(C=C(C(=C2)NC(=O)C3=CC=CC=C3OC)N4CCCC4)N(C1=O)C Isomeric SMILES CN1C2=C(C=C(C(=C2)NC(=O)C3=CC=CC=C3OC)N4CCCC4)N(C1=O)C PubChem CID 40642506 Molecular Weight 380.44
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 19.02, Max Conc. mM: 50; Solvent:ethanol, Max Conc. mg/mL: 3.8, Max Conc. mM: 10
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K2212538