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PGB1 (Prostaglandin B1) - 98%, high purity , CAS No.13345-51-2
a metabolite of PGA1 shown to modify the pressor responses to sympathetic nerve stimulation
Basic Description Synonyms J-006385 | BDBM50390997 | ALPROSTADIL IMPURITY B [EP IMPURITY] | SR-01000000044-6 | BML1-F03 | DTXSID001347609 | NCGC00024019-03 | PGB1 (Prostaglandin B1) | Prosta-8(12),13-dien-1-oicacid, 15-hydroxy-9-oxo-, (13E,15S)- | HY-120665 | SR-01000000044 | NCGC0 Specifications & Purity ≥98% Storage Temp Protected from light,Store at -20°C Shipped In Ice chest + Ice pads Product Description PGB1 (Prostaglandin B1) is a nonenzymatic dehydration product of PGE1 and a metabolite of PGA1 that has been shown to modify the pressor responses to sympathetic nerve stimulation. Furthermore, when PGB1 is oligomerized it has been shown to inhibit phospholipase A|2|, and act as an ionophore for calcium.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 7-[2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopenten-1-yl]heptanoic acid INCHI InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 InChi Key YBHMPNRDOVPQIN-VSOYFRJCSA-N Canonical SMILES CCCCCC(C=CC1=C(C(=O)CC1)CCCCCCC(=O)O)O Isomeric SMILES CCCCC[C@@H](/C=C/C1=C(C(=O)CC1)CCCCCCC(=O)O)O WGK Germany 3 PubChem CID 5280388 Molecular Weight 336.5 Beilstein 2004447
Chemical and Physical Properties Solubility Soluble in acetone (20 mg/ml), methanol (>50 mg/ml), acetonitrile (>50 mg/ml), DMSO (~50 mg/ml), PBS (7.2) (~2 mg/ml), DMF (~50 mg/ml), and ethanol (~50 mg/ml). Insoluble in water. Sensitivity Light sensitive Refractive Index n20D1.55 Boil Point(°C) ~531.4° C at 760 mmHg (Predicted) Melt Point(°C) 69-71°C
Citations of This Product 1. Lihui Xuan, Yin Wang, Can Qu, Yuhui Yan, Wensen Yi, Jingjing Yang, Magdalena Skonieczna, Cuimei Chen, Justyna Miszczyk, Dmitry S. Ivanov, Hesham M.H. Zakaly, Vladimir Markovic, Ruixue Huang. (2023) Metabolomics reveals that PS-NPs promote lung injury by regulating prostaglandin B1 through the cGAS-STING pathway. CHEMOSPHERE, 342 (13): (140108). [PMID:37714480 ] [10.1016/j.chemosphere.2023.140108 ]
References 1. Lihui Xuan, Yin Wang, Can Qu, Yuhui Yan, Wensen Yi, Jingjing Yang, Magdalena Skonieczna, Cuimei Chen, Justyna Miszczyk, Dmitry S. Ivanov, Hesham M.H. Zakaly, Vladimir Markovic, Ruixue Huang. (2023) Metabolomics reveals that PS-NPs promote lung injury by regulating prostaglandin B1 through the cGAS-STING pathway. CHEMOSPHERE, 342 (13): (140108). [PMID:37714480 ] [10.1016/j.chemosphere.2023.140108 ]
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