PHA-543613 , Neuronal acetylcholine receptor protein alpha-7 subunit agonist, CAS No.478149-53-0, Neuronal acetylcholine receptor protein alpha-7 subunit agonist

Item Number

P612780

Grouped product items
SKU	Size	Availability	Price
P612780-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$105.90
P612780-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$176.90
P612780-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$379.90
P612780-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$599.90
P612780-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$949.90

View related series

Basic Description

Synonyms	PHA-543613\|478149-53-0\|PHA-543,613\|(R)-N-(Quinuclidin-3-yl)furo(2,3-C)pyridine-5-carboxamide\|N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide\|R36R9KVD6Y\|CHEMBL214268\|PHA 543613 HYDROCHLORIDE\|DTXSID6047284\|J3.179.420J\|PHA-00543613\|Furo
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	PHA-543613 exhibits rapid brain penetration property.PHA-543613 is a potent selective α7 nAChR agonist. Nicotinic acetylcholine receptors are ligand-gated ion channels activated by nicotine, expressed in multiple tissues, with high functional expression i
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Neuronal acetylcholine receptor protein alpha-7 subunit agonist
Product Description	PHA 543613 is a specific agonist of α7 nAChR (Ki = 8.8 nM) and can be used in studies about the cognitive deficits of Alzheimer's disease and schizophrenia.

Names and Identifiers

IUPAC Name	N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-c]pyridine-5-carboxamide
INCHI	InChI=1S/C15H17N3O2/c19-15(12-7-11-3-6-20-14(11)8-16-12)17-13-9-18-4-1-10(13)2-5-18/h3,6-8,10,13H,1-2,4-5,9H2,(H,17,19)/t13-/m0/s1
InChi Key	IPKZCLGGYKRDES-ZDUSSCGKSA-N
Canonical SMILES	O=C(N[C@H]1CN2CC[C@H]1CC2)c3cc4ccoc4cn3
Isomeric SMILES	C1CN2CCC1[C@H](C2)NC(=O)C3=NC=C4C(=C3)C=CO4
WGK Germany	1
PubChem CID	9930121
Molecular Weight	271.31

PubChem CID

CAS Registry No.

ChEMBL Ligand

Wikipedia

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H319:Causes serious eye irritation
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help.
WGK Germany	1
RIDADR	NONHforallmodesoftransport

Solution Calculators

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.

Basic Description