PHA-767491 - ≥98%, high purity , CAS No.845714-00-3, Inhibitor of MAPK activated protein kinase 2;Inhibitor of ribosomal protein S6 kinase A4

Item Number

P127009

• Synonyms: 2-(4-pyridyl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one | BDBM27344 | SMR004702829 | CAY10572(PHA-767491) | CHEBI:95058 | MLS006011036 | 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one | 2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: PHA-767491 (CAY10572) is a potent, ATP-competitive dual Cdc7/Cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication. Cdc7 kinase is known to promote the activity of DNA replication origins in eukaryotic orga
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of MAPK activated protein kinase 2;Inhibitor of ribosomal protein S6 kinase A4
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

PHA-767491 (CAY10572) is a potent, ATP-competitive dual Cdc7/Cdk9 inhibitor with IC50 values of 10/34 nM. IC50 Value: 10 nM(Cdc7); 34 nM(Cdk9)
A potent, reversible, and ATP-competitive inhibitor of Cdc7 and Cdk9