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Phaclofen - 98%, high purity , CAS No.114012-12-3, Antagonist of GABA B receptor
a selective GABABreceptor antagonist
Basic Description Synonyms NCGC00261652-01 | P-[3-Amino-2-(4-chlorophenyl)propyl]-Phosphonic acid | NCGC00015781-04 | VSGNGLJPOGUDON-UHFFFAOYSA-N | SR-01000075640-3 | Phaclofen, solid | (+/-)-3-Amino-2-(4-chlorophenyl)-propylphosphomic acid | Lopac0_000967 | NCGC00015781-06 | Q7179 Specifications & Purity Moligand™, ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of GABA B receptor Product Description Phaclofen is a selective antagonist of the GABA|B|receptor. Phaclofen is a phosphonic acid derivative of the GABA|B|agonist Baclofen , and is described to competitively antagonize responses to exogenously applied Baclofen.
Product Properties pKa pKₐ: 1.87 (Predicted), pKₐ: 9.58 (Predicted)
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name [3-amino-2-(4-chlorophenyl)propyl]phosphonic acid INCHI InChI=1S/C9H13ClNO3P/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H2,12,13,14) InChi Key VSGNGLJPOGUDON-UHFFFAOYSA-N Canonical SMILES C1=CC(=CC=C1C(CN)CP(=O)(O)O)Cl Isomeric SMILES C1=CC(=CC=C1C(CN)CP(=O)(O)O)Cl WGK Germany 3 RTECS SZ6507000 PubChem CID 1641 Molecular Weight 249.63
Chemical and Physical Properties Solubility Soluble in 1N NaOH (100 mM), 0.1 M HCl (13.3 mg/ml), methanol (19.3 mg/ml), water, and DMSO. Refractive Index n20D1.59 (Predicted) Boil Point(°C) ~467.1° C at 760 mmHg (Predicted)
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 3 RTECS SZ6507000
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