Grouped product items

SKU

Size

Availability

Price

Qty

P121447-25mg

25mg

Available within 8-12 weeks(?)

$12.90

P121447-100mg

100mg

Available within 4-8 weeks(?)

$39.90

P121447-250mg

250mg

Available within 8-12 weeks(?)

$69.90

P121447-1g

Available within 8-12 weeks(?)

$124.90

Basic Description

Synonyms	Phe-ala \| 3918-87-4 \| Phenylalanylalanine \| H-PHE-ALA-OH \| L-Phenylalanyl-L-alanine \| (S)-2-((S)-2-Amino-3-phenylpropanamido)propanoic acid \| (2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]propanoic acid \| CHEMBL429950 \| CHEBI:73630 \| FA dipeptide \| F-A Dipeptide \| MFCD00037229
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

ACE Tclin Angiotensin-converting enzyme (1423 Activities)

Discover Target: ACE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MME Tclin Neprilysin (838 Activities)

Discover Target: MME

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC15A1 Tchem Oligopeptide transporter small intestine isoform (922 Activities)

Discover Target: SLC15A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC15A2 Tchem Solute carrier family 15 member 2 (186 Activities)

Discover Target: SLC15A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]propanoic acid
INCHI	InChI=1S/C12H16N2O3/c1-8(12(16)17)14-11(15)10(13)7-9-5-3-2-4-6-9/h2-6,8,10H,7,13H2,1H3,(H,14,15)(H,16,17)/t8-,10-/m0/s1
InChi Key	MIDZLCFIAINOQN-WPRPVWTQSA-N
Canonical SMILES	CC(C(=O)O)NC(=O)C(CC1=CC=CC=C1)N
Isomeric SMILES	C[C@@H](C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)N
WGK Germany	3
PubChem CID	5488196
Molecular Weight	236.27

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
H2408663	Certificate of Analysis	Apr 01, 2024	P121447
H2408664	Certificate of Analysis	Apr 01, 2024	P121447
H2408665	Certificate of Analysis	Apr 01, 2024	P121447
B1412073	Certificate of Analysis	Feb 16, 2022	P121447

Safety and Hazards(GHS)

WGK Germany	3

References

1. Knütter I, Theis S, Hartrodt B, Born I, Brandsch M, Daniel H, Neubert K. (2001) A novel inhibitor of the mammalian peptide transporter PEPT1.. Biochemistry, 40 (14): (4454-8). [PMID:11284702]
2. Wenzel U, Diehl D, Herget M, Daniel H. (1998) Endogenous expression of the renal high-affinity H+-peptide cotransporter in LLC-PK1 cells.. Am J Physiol, 275 (6 Pt 1): (C1573-9). [PMID:9843719]
3. Rühl A, Hoppe S, Frey I, Daniel H, Schemann M. (2005) Functional expression of the peptide transporter PEPT2 in the mammalian enteric nervous system.. J Comp Neurol, 490 (1): (1-11). [PMID:16041713]
4. Rohm F, Skurk T, Daniel H, Spanier B. (2019) Appearance of Di- and Tripeptides in Human Plasma after a Protein Meal Does Not Correlate with PEPT1 Substrate Selectivity.. Mol Nutr Food Res, 63 (5): (e1801094). [PMID:30521147]
5. Arakawa H, Yamada H, Arai K, Kawanishi T, Nitta N, Shibata S, Matsumoto E, Yano K, Kato Y, Kumamoto T et al.. (2020) Possible utility of peptide-transporter-targeting [¹⁹F]dipeptides for visualization of the biodistribution of cancers by nuclear magnetic resonance imaging.. Int J Pharm, 586 (3): (119575). [PMID:32622809]
6. D Meredith,C A Boyd. (1995-08-01) Dipeptide transport characteristics of the apical membrane of rat lung type II pneumocytes.. The American journal of physiology, 269 ((2 Pt 1)): (L137-L143). [PMID:7653574]
7. F Döring,S Theis,H Daniel. (1997-03-27) Expression and functional characterization of the mammalian intestinal peptide transporter PepT1 in the methylotropic yeast Pichia pastoris.. Biochemical and biophysical research communications, 232 ((3)): (656-662). [PMID:9126331]
8. U Wenzel,D Diehl,M Herget,S Kuntz,H Daniel. (1999-02-16) Regulation of the high-affinity H+/peptide cotransporter in renal LLC-PK1 cells.. Journal of cellular physiology, 178 ((3)): (341-348). [PMID:9989780]
9. C H Görbitz. (2001-05-16) L-Phenylalanyl-L-alanine dihydrate.. Acta crystallographica. Section C, Crystal structure communications, 57 ((Pt 5)): (575-576). [PMID:11353256]
10. I Hussain,T Zanic-Grubisic,Y Kudo,C A Boyd. (2001-12-01) Functional and molecular characterization of a peptide transporter in the rat PC12 neuroendocrine cell line.. FEBS letters, 508 ((3)): (350-354). [PMID:11728450]
11. Jaeseung Kim,Gregory Hewitt,Patrick Carroll,Scott McN Sieburth. (2005-07-16) Silanediol inhibitors of angiotensin-converting enzyme. Synthesis and evaluation of four diastereomers of Phe[Si]Ala dipeptide analogues.. The Journal of organic chemistry, 70 ((15)): (5781-5789). [PMID:16018669]
12. Nick C Polfer,Jos Oomens,Robert C Dunbar. (2008-02-23) Alkali metal complexes of the dipeptides PheAla and AlaPhe: IRMPD spectroscopy.. Chemphyschem : a European journal of chemical physics and physical chemistry, 9 ((4)): (579-589). [PMID:18293344]
13. Esteban E Baquero,William H James,Soo Hyuk Choi,Samuel H Gellman,Timothy S Zwier. (2008-03-19) Single-conformation ultraviolet and infrared spectroscopy of model synthetic foldamers: beta-peptides Ac-beta3-hPhe-beta3-hAla-NHMe and Ac-beta3-hAla-beta3-hPhe-NHMe.. Journal of the American Chemical Society, 130 ((14)): (4795-4807). [PMID:18345673]
14. Sedireng M Ndolo,Kwenga Sichilongo,Amos Massele,Enoch Sepako,Sandro Vento. (2015-10-22) An Investigation of Liquid Chromatography-Mass Spectral Attributes and Analytical Performance Characteristics of Tenofovir, Emtricitabine and Efavirenz in Human Plasma.. Journal of analytical toxicology, 40 ((1)): (49-57). [PMID:26487641]
15. Zhanfei Liu,Shuting Liu. (2015-12-10) High Phosphate Concentrations Accelerate Bacterial Peptide Decomposition in Hypoxic Bottom Waters of the Northern Gulf of Mexico.. Environmental science & technology, 50 ((2)): (676-684). [PMID:26650147]
16. Venkat N Are,Ashwani Kumar,Saurabh Kumar,Venuka Durani Goyal,Biplab Ghosh,Deepak Bhatnagar,Sahayog N Jamdar,Ravindra D Makde. (2016-11-07) Crystal structure and biochemical investigations reveal novel mode of substrate selectivity and illuminate substrate inhibition and allostericity in a subfamily of Xaa-Pro dipeptidases.. Biochimica et biophysica acta, 1865 ((2)): (153-164). [PMID:27816563]
17. Mukul Sonker,Radim Knob,Vishal Sahore,Adam T Woolley. (2017-03-09) Integrated electrokinetically driven microfluidic devices with pH-mediated solid-phase extraction coupled to microchip electrophoresis for preterm birth biomarkers.. Electrophoresis, 38 ((13-14)): (1743-1754). [PMID:28272749]
18. Jenni Tienaho,Maarit Karonen,Riina Muilu-Mäkelä,Kristiina Wähälä,Eduardo Leon Denegri,Robert Franzén,Matti Karp,Ville Santala,Tytti Sarjala. (2019-06-28) Metabolic Profiling of Water-Soluble Compounds from the Extracts of Dark Septate Endophytic Fungi (DSE) Isolated from Scots Pine (Pinus sylvestris L.) Seedlings Using UPLC-Orbitrap-MS.. Molecules (Basel, Switzerland), 24 ((12)): [PMID:31242564]
19. G Borin,P Giusti,L Cima. (1983-10-17) Analgesic properties of N-terminal substituted phenylalanyl-alanine.. Life sciences, 33 ((16)): (1575-1580). [PMID:6355734]
20. J J Chen,L A Barber,J Dymshitz,M R Vasko. (1996-01-01) Peptidase inhibitors improve recovery of substance P and calcitonin gene-related peptide release from rat spinal cord slices.. Peptides, 17 ((1)): (31-37). [PMID:8822507]
21. F Döring,D Dorn,U Bachfischer,S Amasheh,M Herget,H Daniel. (1996-12-15) Functional analysis of a chimeric mammalian peptide transporter derived from the intestinal and renal isoforms.. The Journal of physiology, 497 ( Pt 3) (773-779). [PMID:9003562]
22. A K Stewart,C A Boyd,R D Vaughan-Jones. (1999-03-06) A novel role for carbonic anhydrase: cytoplasmic pH gradient dissipation in mouse small intestinal enterocytes.. The Journal of physiology, 516 ( Pt 1) (209-217). [PMID:10066935]
23. T Verri,M Maffia,A Danieli,M Herget,U Wenzel,H Daniel,C Storelli. (2000-09-08) Characterisation of the H(+)/peptide cotransporter of eel intestinal brush-border membranes.. The Journal of experimental biology, 203 ((Pt 19)): (2991-3001). [PMID:10976035]
24. Jason Lamar,Jingdan Hu,Ana Belen Bueno,Hsiu-Chiung Yang,Deqi Guo,James D Copp,James McGee,Bruce Gitter,David Timm,Patrick May,James McCarthy,Shu-Hui Chen. (2003-12-20) Phe*-Ala-based pentapeptide mimetics are BACE inhibitors: P2 and P3 SAR.. Bioorganic & medicinal chemistry letters, 14 ((1)): (239-243). [PMID:14684335]
25. Shu-Hui Chen,Jason Lamar,Deqi Guo,Todd Kohn,Hsiu-Chiung Yang,James McGee,David Timm,Jon Erickson,Yvonne Yip,Patrick May,James McCarthy. (2003-12-20) P3 cap modified Phe*-Ala series BACE inhibitors.. Bioorganic & medicinal chemistry letters, 14 ((1)): (245-250). [PMID:14684336]
26. Robert C Dunbar,Jeffrey D Steill,Jos Oomens. (2010-09-08) Cationized phenylalanine conformations characterized by IRMPD and computation for singly and doubly charged ions.. Physical chemistry chemical physics : PCCP, 12 ((41)): (13383-13393). [PMID:20820591]
27. Marina López-García,Roberto Romero-González,Antonia Garrido Frenich. (2017-02-06) Determination of rodenticides and related metabolites in rabbit liver and biological matrices by liquid chromatography coupled to Orbitrap high resolution mass spectrometry.. Journal of pharmaceutical and biomedical analysis, 137 (235-242). [PMID:28160742]
28. Marina López-García,Roberto Romero-González,Marina Lacasaña,Antonia Garrido Frenich. (2017-09-18) Semiautomated determination of neonicotinoids and characteristic metabolite in urine samples using TurboFlow™ coupled to ultra high performance liquid chromatography coupled to Orbitrap analyzer.. Journal of pharmaceutical and biomedical analysis, 146 (378-386). [PMID:28918328]

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Phe-Ala - 98%, high purity , CAS No.3918-87-4

Basic Description

Associated Targets(Human)

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Safety and Hazards(GHS)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

SKU	Size	Availability	Price
P121447-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$12.90
P121447-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$39.90
P121447-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$69.90
P121447-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$124.90