Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P129203-1g | 1g | In stock | $9.90 | |
P129203-5g | 5g | In stock | $15.90 | |
P129203-25g | 25g | In stock | $60.90 |
Competitive Vitamin K-dependent carboxylase antagonist. NQO1 inhibitor.
Synonyms | PHENINDIONE [MI] | Rectadione;phenylindandione | BSPBio_002499 | Indon | Phenindione [USP:INN:BAN] | DTXCID803453 | BSPBio_000555 | Indion | 2-phenylindane-1,3-dione | CHEBI:8066 | P1029 | Phenindione (Rectadione) | SPBio_001097 | Thrombasal | Opera_ID_19 |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Competitive Vitamin K-dependent carboxylase antagonist (IC 50 = 19 μM). NQO1 inhibitor. Shows anticoagulant effects in vivo . Orally active. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
ALogP | 2.9 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 2-phenylindene-1,3-dione |
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INCHI | InChI=1S/C15H10O2/c16-14-11-8-4-5-9-12(11)15(17)13(14)10-6-2-1-3-7-10/h1-9,13H |
InChi Key | NFBAXHOPROOJAW-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C(C=C1)C2C(=O)C3=CC=CC=C3C2=O |
Isomeric SMILES | C1=CC=C(C=C1)C2C(=O)C3=CC=CC=C3C2=O |
Alternate CAS | 83-12-5 |
PubChem CID | 4760 |
NSC Number | 41693 |
MeSH Entry Terms | 2 Phenyl 1,3 indandione;2-Phenyl-1,3-indandione;Dindevan;Fenilin;Phenindione;Phenylindanedione;Phenyline;Pindione |
Molecular Weight | 222.24 |
DrugBank Ligand | DB00498 |
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PubChem CID | 4760 |
CAS Registry No. | 83-12-5 |
ChEMBL Ligand | CHEMBL711 |
Wikipedia | Phenindione |
PEP | phenindione |
Reactome Reaction | R-HSA-9026967 |
Reactome Drug | R-ALL-9035044 |
RCSB PDB Ligand | UAS |
DrugCentral Ligand | 2130 |
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Solubility | DMSO 44 mg/mL Water <1 mg/mL Ethanol 15 mg/mL |
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Melt Point(°C) | 148 °C |
Pictogram(s) | GHS06, GHS07 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed H317:May cause an allergic skin reaction |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. |
Merck Index | 7234 |