Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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P129843-1g | 1g | In stock | $48.90 | |
P129843-5g | 5g | In stock | $220.90 | |
P129843-25g | 25g | In stock | $992.90 |
Irreversible calmodulin antagonist and potent, nonselective, irreversible α-adrenoceptor antagonist
Synonyms | FT-0673569 | NCGC00093699-04 | NSC759572 | NSC-759572 | PHENOXYBENZAMINE HYDROCHLORIDE (IARC) | MLS002222313 | Tox21_302978 | CPD000058422 | N-2-Phenoxyisopropyl-N-benzyl-chloroethylamine hydrochloride | phenoxybenzamide hydrochloride | PHENOXYBENZAMINE H |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Phenoxybenzamine is a cell-permeable, non-specific, irreversible AR (α-adrenergic) antagonist that also acts as an CaM inhibitor. Phenoxybenzamine inhibits calmodulin-stimulated phosphodiesterase activity. This product has been shown to inhibit cGMP accum |
Storage Temp | Store at 2-8°C,Protected from light |
Shipped In | Wet ice |
Action Type | ANTAGONIST |
Mechanism of action | Adrenergic receptor alpha antagonist |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Phenoxybenzamine HCl is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488195285 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488195285 |
IUPAC Name | N-benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-amine;hydrochloride |
INCHI | InChI=1S/C18H22ClNO.ClH/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17;/h2-11,16H,12-15H2,1H3;1H |
InChi Key | VBCPVIWPDJVHAN-UHFFFAOYSA-N |
Canonical SMILES | CC(COC1=CC=CC=C1)N(CCCl)CC2=CC=CC=C2.Cl |
Isomeric SMILES | CC(COC1=CC=CC=C1)N(CCCl)CC2=CC=CC=C2.Cl |
WGK Germany | 3 |
RTECS | DP3750000 |
PubChem CID | 5284441 |
Molecular Weight | 340.3 |
Reaxy-Rn | 3747029 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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D2320876 | Certificate of Analysis | Mar 15, 2023 | P129843 |
D2320877 | Certificate of Analysis | Mar 15, 2023 | P129843 |
D2320879 | Certificate of Analysis | Mar 15, 2023 | P129843 |
D2320938 | Certificate of Analysis | Mar 15, 2023 | P129843 |
F1510058 | Certificate of Analysis | Jan 25, 2023 | P129843 |
Solubility | DMSO 68 mg/mL Water 17 mg/mL Ethanol 68 mg/mL |
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Sensitivity | Light sensitive、Air sensitive |
Melt Point(°C) | 139 °C |
Pictogram(s) | GHS08, GHS07 |
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Signal | Warning |
Hazard Statements | H351:Suspected of causing cancer H302:Harmful if swallowed |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. |
WGK Germany | 3 |
RTECS | DP3750000 |
Reaxy-Rn | 3747029 |
Merck Index | 7256 |