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Phenserine - >98%, high purity , CAS No.101246-66-6
Basic Description Synonyms DB04892 | HY-103374 | Q-100312 | HMS3261J07 | NCGC00261208-01 | Romantrene Brown FBR | BRD-K46580984-001-01-0 | (+/-)-Phenserine | 2-METHYLBUTYL ISOVALERATE, (+/-)- | Q27095557 | BUNTANETAP, (+/-)- | N-phenylcarbamoyleseroline | Pyrrolo[2,3-b]indol-5-ol, Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Phenserine ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine and is a potent, noncompetitive, long-acting and selective AChE inhibitor. Phenserine reduces β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ) formation. Phenserine im Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description Phenserine is a physostigmine analog that inhibits AChE( acetylcholinesterase). Inhibits production of Aβ and amyloid precursor protein (APP). Improves morris water maze performance of scopolamine-treated rats.
Product Properties pKa pKa: 13.05 (Predicted), pKa: 8.36 (Predicted)
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name [(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-phenylcarbamate INCHI InChI=1S/C20H23N3O2/c1-20-11-12-22(2)18(20)23(3)17-10-9-15(13-16(17)20)25-19(24)21-14-7-5-4-6-8-14/h4-10,13,18H,11-12H2,1-3H3,(H,21,24)/t18-,20+/m1/s1 InChi Key PBHFNBQPZCRWQP-QUCCMNQESA-N Canonical SMILES CC12CCN(C1N(C3=C2C=C(C=C3)OC(=O)NC4=CC=CC=C4)C)C Isomeric SMILES C[C@@]12CCN([C@@H]1N(C3=C2C=C(C=C3)OC(=O)NC4=CC=CC=C4)C)C WGK Germany 3 RTECS UY8586000 PubChem CID 192706 Molecular Weight 337.42
Chemical and Physical Properties Solubility Soluble in DMSO (10 mM), ethanol (25 mM), and water (<2 mg/ml). Refractive Index n20D1.63 (Predicted) Boil Point(°C) ~468.7° C at 760 mmHg (Predicted) Melt Point(°C) 180.78° C (Predicted)
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 3 RTECS UY8586000 Merck Index 5.625 RIDADR NONHforallmodesoftransport
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