Phenylmethanesulfonyl fluoride - ≥98.0% (GC), high purity , CAS No.329-98-6

  • ≥98%(GC)
Item Number
P105539
Grouped product items
SKUSizeAvailabilityPrice Qty
P105539-1g
1g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$12.90
P105539-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$39.90
P105539-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$119.90
P105539-100g
100g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$307.90

Non-selective protease inhibitor; also blocks anandamide metabolism

Basic Description

SynonymsPhenylmethylsulfonyl fluoride | PMSF | 329-98-6 | phenylmethanesulfonyl fluoride | Benzylsulfonyl fluoride | Benzenemethanesulfonyl fluoride | alpha-TOLUENESULFONYL FLUORIDE | Phenylmethylsulfonylfluoride | Benzylsulphonyl fluoride | alpha-Toluenesulphonyl fluoride | NSC 884
Specifications & Purity≥98%(GC)
Biochemical and Physiological MechanismsNon-selective protease inhibitor; irreversibly sulfonates key active site serine residues in serine proteases, acetylcholinesterases, and thiol proteases. Blocks metabolism of anandamidein a rodent model of cannabimimetic activity. Unstable in water (t1/2
Storage TempStore at 2-8°C,Argon charged
Shipped InWet ice
Product Description

Trypsin and chymotrypsin inhibitor.Potentiates the effects of ischemia on brain mitochondria through its inhibition of phospholipase C.

Associated Targets(Human)

ELANE Tclin Neutrophil elastase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CES1 Tchem Liver carboxylesterase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

DAGLA Tchem Sn1-specific diacylglycerol lipase alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PRTN3 Tchem Myeloblastin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FAAH Tchem Fatty-acid amide hydrolase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PRSS1 Tclin Trypsin-1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PARL Tchem Presenilins-associated rhomboid-like protein, mitochondrial 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MGLL Tchem Monoglyceride lipase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Leukocyte elastase 8173 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Leukocyte proteinase 3 201 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Acyl coenzyme A:cholesterol acyltransferase 1029 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

A498 42825 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

ACHN 49357 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

CAKI-1 44928 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

CCRF-CEM 65223 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

COLO 205 50209 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

DU-145 51482 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

HT-29 80576 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

K562 73714 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

KM12 47707 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

M14 47487 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

MCF7 126967 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

MOLT-4 49676 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

OVCAR-3 48710 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

OVCAR-4 44535 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

OVCAR-5 45555 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

OVCAR-8 47708 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

PC-3 62116 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

RPMI-8226 44974 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

SF-295 48000 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

SK-MEL-2 46422 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

SK-MEL-28 48833 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

SK-MEL-5 47095 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

SK-OV-3 52876 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

SN12C 47755 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

SNB-19 46794 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

TK-10 45540 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

U-251 51189 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

UACC-257 46019 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

UACC-62 47335 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

UO-31 46270 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

786-0 47912 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

A549 127892 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

NCI/ADR-RES 33767 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

EKVX 44102 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

NCI-H322M 45589 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

HCC 2998 41480 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

HCT-116 91556 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

HOP-92 41141 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

NCI-H460 60772 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

SF-268 49410 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

IGROV-1 47897 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

LOX IMVI 44321 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

HOP-62 47048 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

MDA-MB-435 38290 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

MDA-N 28205 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Malme-3M 44254 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

MDA-MB-231 73002 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Trypsin 394 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Histone deacetylase 6 222 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Anandamide amidohydrolase 3907 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Toxoplasma gondii 4585 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mus musculus 284745 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Vero 26788 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Replicase polyprotein 1ab 378 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Presenilins-associated rhomboid-like protein, mitochondrial 3 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Rhomboid protease GlpG 20 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

SARS-CoV-2 38078 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name phenylmethanesulfonyl fluoride
INCHI InChI=1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2
InChi Key YBYRMVIVWMBXKQ-UHFFFAOYSA-N
Canonical SMILES C1=CC=C(C=C1)CS(=O)(=O)F
Isomeric SMILES C1=CC=C(C=C1)CS(=O)(=O)F
WGK Germany 3
RTECS XT8040000
PubChem CID 4784
UN Number 2928
Molecular Weight 174.19
Beilstein 2088311
Reaxy-Rn 2088311

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

15 results found

Lot NumberCertificate TypeDateItem
E2406040Certificate of AnalysisFeb 10, 2023 P105539
H2308420Certificate of AnalysisFeb 10, 2023 P105539
H2308448Certificate of AnalysisFeb 10, 2023 P105539
H2308457Certificate of AnalysisFeb 10, 2023 P105539
A2303645Certificate of AnalysisNov 11, 2022 P105539
A2303646Certificate of AnalysisNov 11, 2022 P105539
A2303651Certificate of AnalysisNov 11, 2022 P105539
A2303662Certificate of AnalysisNov 11, 2022 P105539
L2313042Certificate of AnalysisNov 11, 2022 P105539
G2230369Certificate of AnalysisJun 25, 2022 P105539
G2230373Certificate of AnalysisJun 25, 2022 P105539
G2230374Certificate of AnalysisJun 25, 2022 P105539
A2203580Certificate of AnalysisDec 17, 2021 P105539
A2203581Certificate of AnalysisDec 17, 2021 P105539
A2203582Certificate of AnalysisDec 17, 2021 P105539

more

Chemical and Physical Properties

SolubilitySolvent:ethanol, Max Conc. mg/mL: 17.42, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 17.42, Max Conc. mM: 100
SensitivityMoisture Sensitive
Boil Point(°C)85°C/0.3mmHg
Melt Point(°C)92-95°C

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS05
Signal Danger
Hazard Statements

H301:Toxic if swallowed

H314:Causes severe skin burns and eye damage

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P310:Immediately call a POISON CENTER or doctor/physician.

WGK Germany 3
RTECS XT8040000
Reaxy-Rn 2088311
Merck Index 7542

Related Documents

Citations of This Product

1. Cai Jing, Wu Hao, Wang Chenxing, Chen Yujiao, Zhang Dingli, Guan Shiwei, Fu Beilei, Jin Yingli, Qian Cao.  (2023)  Sec1 regulates intestinal mucosal immunity in a mouse model of inflammatory bowel disease.  BMC IMMUNOLOGY,  24  (1): (1-12).  [PMID:38066482]
2. Benjin Chen, Liang Xiao, Wanni Wang, Lingling Xu, Yechun Jiang, Guoqiang Zhang, Lin Liu, Xiaohu Li, Yongqiang Yu, Haisheng Qian.  (2023)  Bi2–xMnxO3 Nanospheres Engaged Radiotherapy with Amplifying DNA Damage.  ACS Applied Materials & Interfaces,  15  (28): (33903–33915).  [PMID:37410709]
3. Zhiguo Wu, Yuchan Wu, Weicheng Zhong, Qingmei Zhong, Shengfang Rao, Dongshan Yu, Xiaolu Luo, Fang Qiu, Zhiying Song, Di Jin, Maoxing Ai, Yu Lan, Gongchang Zhang, Shufeng Song, Baogang Xie, Shuilin Sun.  (2023)  The hepatoprotective effect of aspirin on carbon tetrachloride‑induced hepatic fibrosis via inhibition of TGFβ‑1 pathway and pro‑inflammatory cytokines IL‑1β and COX‑2 in rats.  Experimental and Therapeutic Medicine,  25  (5): (1-7).  [PMID:37114173]
4. Yi Shi, Qian Wu, Yi Lu, Ling-Peng Meng, Xiao-Ling Xu, Xiao-Juan Wang, Wei Chen.  (2023)  Arginine-Glycine-Aspartic Acid-anchored Curcumin-based Nanotherapeutics Inhibit Pyroptosis-induced Cytokine Release Syndrome for In Vivo and In Vitro Sepsis Applications.  CURRENT PHARMACEUTICAL DESIGN,  29  (4): ( 283–294).  [PMID:36722481]
5. Lihuang Wu, Yuqi Wang, Xinyue Zhao, Hongli Mao, Zhongwei Gu.  (2023)  Investigating the Biodegradation Mechanism of Poly(trimethylene carbonate): Macrophage-Mediated Erosion by Secreting Lipase.  BIOMACROMOLECULES,  24  (2): (921–928).  [PMID:36644840]
6. Tingting Wu, Xushun Liu, Hanjun Chen, Ying Liu, Yu Cao.  (2023)  An in situ exosomal miRNA sensing biochip based on multi-branched localized catalytic hairpin assembly and photonic crystals.  BIOSENSORS & BIOELECTRONICS,  222  (115013).  [PMID:36529054]
7. Ruohua Qu, Mi Chen, Jingfu Liu, Qiting Xie, Na Liu, Fei Ge.  (2023)  Blockage of ATPase-mediated energy supply inducing metabolic disturbances in algal cells under silver nanoparticles stress.  Journal of Environmental Sciences,  131  (141).  [PMID:37225375]
8. Yan-Mei Zhang, Khas Erdene, Ya-Bo Zhao, Chang-Qing Li, Li Wang, Feng Tian, Chang-Jin Ao, Hai Jin.  (2022)  Role of white adipose tissue browning in cold seasonal acclimation in grazing Mongolian sheep (Ovis aries).  JOURNAL OF THERMAL BIOLOGY,  109  (103333).  [PMID:36195394]
9. Changkai Zhou, Jing Gao, Haijun Qu, Long Xu, Bin Zhang, Qie Guo, Fanbo Jing.  (2022)  Anti-inflammatory Mechanism of Action of Benzoylmesaconine in Lipopolysaccharide-Stimulated RAW264.7 Cells.  Evidence-based Complementary and Alternative Medicine,  2022  (7008907).  [PMID:35873638]

References

1. Cai Jing, Wu Hao, Wang Chenxing, Chen Yujiao, Zhang Dingli, Guan Shiwei, Fu Beilei, Jin Yingli, Qian Cao.  (2023)  Sec1 regulates intestinal mucosal immunity in a mouse model of inflammatory bowel disease.  BMC IMMUNOLOGY,  24  (1): (1-12).  [PMID:38066482]
2. Benjin Chen, Liang Xiao, Wanni Wang, Lingling Xu, Yechun Jiang, Guoqiang Zhang, Lin Liu, Xiaohu Li, Yongqiang Yu, Haisheng Qian.  (2023)  Bi2–xMnxO3 Nanospheres Engaged Radiotherapy with Amplifying DNA Damage.  ACS Applied Materials & Interfaces,  15  (28): (33903–33915).  [PMID:37410709]
3. Zhiguo Wu, Yuchan Wu, Weicheng Zhong, Qingmei Zhong, Shengfang Rao, Dongshan Yu, Xiaolu Luo, Fang Qiu, Zhiying Song, Di Jin, Maoxing Ai, Yu Lan, Gongchang Zhang, Shufeng Song, Baogang Xie, Shuilin Sun.  (2023)  The hepatoprotective effect of aspirin on carbon tetrachloride‑induced hepatic fibrosis via inhibition of TGFβ‑1 pathway and pro‑inflammatory cytokines IL‑1β and COX‑2 in rats.  Experimental and Therapeutic Medicine,  25  (5): (1-7).  [PMID:37114173]
4. Yi Shi, Qian Wu, Yi Lu, Ling-Peng Meng, Xiao-Ling Xu, Xiao-Juan Wang, Wei Chen.  (2023)  Arginine-Glycine-Aspartic Acid-anchored Curcumin-based Nanotherapeutics Inhibit Pyroptosis-induced Cytokine Release Syndrome for In Vivo and In Vitro Sepsis Applications.  CURRENT PHARMACEUTICAL DESIGN,  29  (4): ( 283–294).  [PMID:36722481]
5. Lihuang Wu, Yuqi Wang, Xinyue Zhao, Hongli Mao, Zhongwei Gu.  (2023)  Investigating the Biodegradation Mechanism of Poly(trimethylene carbonate): Macrophage-Mediated Erosion by Secreting Lipase.  BIOMACROMOLECULES,  24  (2): (921–928).  [PMID:36644840]
6. Tingting Wu, Xushun Liu, Hanjun Chen, Ying Liu, Yu Cao.  (2023)  An in situ exosomal miRNA sensing biochip based on multi-branched localized catalytic hairpin assembly and photonic crystals.  BIOSENSORS & BIOELECTRONICS,  222  (115013).  [PMID:36529054]
7. Ruohua Qu, Mi Chen, Jingfu Liu, Qiting Xie, Na Liu, Fei Ge.  (2023)  Blockage of ATPase-mediated energy supply inducing metabolic disturbances in algal cells under silver nanoparticles stress.  Journal of Environmental Sciences,  131  (141).  [PMID:37225375]
8. Yan-Mei Zhang, Khas Erdene, Ya-Bo Zhao, Chang-Qing Li, Li Wang, Feng Tian, Chang-Jin Ao, Hai Jin.  (2022)  Role of white adipose tissue browning in cold seasonal acclimation in grazing Mongolian sheep (Ovis aries).  JOURNAL OF THERMAL BIOLOGY,  109  (103333).  [PMID:36195394]
9. Changkai Zhou, Jing Gao, Haijun Qu, Long Xu, Bin Zhang, Qie Guo, Fanbo Jing.  (2022)  Anti-inflammatory Mechanism of Action of Benzoylmesaconine in Lipopolysaccharide-Stimulated RAW264.7 Cells.  Evidence-based Complementary and Alternative Medicine,  2022  (7008907).  [PMID:35873638]

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