Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P105539-1g | 1g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $12.90 | |
P105539-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $39.90 | |
P105539-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $119.90 | |
P105539-100g | 100g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $307.90 |
Non-selective protease inhibitor; also blocks anandamide metabolism
Synonyms | Phenylmethylsulfonyl fluoride | PMSF | 329-98-6 | phenylmethanesulfonyl fluoride | Benzylsulfonyl fluoride | Benzenemethanesulfonyl fluoride | alpha-TOLUENESULFONYL FLUORIDE | Phenylmethylsulfonylfluoride | Benzylsulphonyl fluoride | alpha-Toluenesulphonyl fluoride | NSC 884 |
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Specifications & Purity | ≥98%(GC) |
Biochemical and Physiological Mechanisms | Non-selective protease inhibitor; irreversibly sulfonates key active site serine residues in serine proteases, acetylcholinesterases, and thiol proteases. Blocks metabolism of anandamidein a rodent model of cannabimimetic activity. Unstable in water (t1/2 |
Storage Temp | Store at 2-8°C,Argon charged |
Shipped In | Wet ice |
Product Description | Trypsin and chymotrypsin inhibitor.Potentiates the effects of ischemia on brain mitochondria through its inhibition of phospholipase C. |
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IUPAC Name | phenylmethanesulfonyl fluoride |
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INCHI | InChI=1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2 |
InChi Key | YBYRMVIVWMBXKQ-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C(C=C1)CS(=O)(=O)F |
Isomeric SMILES | C1=CC=C(C=C1)CS(=O)(=O)F |
WGK Germany | 3 |
RTECS | XT8040000 |
PubChem CID | 4784 |
UN Number | 2928 |
Molecular Weight | 174.19 |
Beilstein | 2088311 |
Reaxy-Rn | 2088311 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
E2406040 | Certificate of Analysis | Feb 10, 2023 | P105539 |
H2308420 | Certificate of Analysis | Feb 10, 2023 | P105539 |
H2308448 | Certificate of Analysis | Feb 10, 2023 | P105539 |
H2308457 | Certificate of Analysis | Feb 10, 2023 | P105539 |
A2303645 | Certificate of Analysis | Nov 11, 2022 | P105539 |
A2303646 | Certificate of Analysis | Nov 11, 2022 | P105539 |
A2303651 | Certificate of Analysis | Nov 11, 2022 | P105539 |
A2303662 | Certificate of Analysis | Nov 11, 2022 | P105539 |
L2313042 | Certificate of Analysis | Nov 11, 2022 | P105539 |
G2230369 | Certificate of Analysis | Jun 25, 2022 | P105539 |
G2230373 | Certificate of Analysis | Jun 25, 2022 | P105539 |
G2230374 | Certificate of Analysis | Jun 25, 2022 | P105539 |
A2203580 | Certificate of Analysis | Dec 17, 2021 | P105539 |
A2203581 | Certificate of Analysis | Dec 17, 2021 | P105539 |
A2203582 | Certificate of Analysis | Dec 17, 2021 | P105539 |
Solubility | Solvent:ethanol, Max Conc. mg/mL: 17.42, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 17.42, Max Conc. mM: 100 |
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Sensitivity | Moisture Sensitive |
Boil Point(°C) | 85°C/0.3mmHg |
Melt Point(°C) | 92-95°C |
Pictogram(s) | GHS06, GHS05 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed H314:Causes severe skin burns and eye damage |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. |
WGK Germany | 3 |
RTECS | XT8040000 |
Reaxy-Rn | 2088311 |
Merck Index | 7542 |
Starting at $35.90
Starting at $161.90
1. Cai Jing, Wu Hao, Wang Chenxing, Chen Yujiao, Zhang Dingli, Guan Shiwei, Fu Beilei, Jin Yingli, Qian Cao. (2023) Sec1 regulates intestinal mucosal immunity in a mouse model of inflammatory bowel disease. BMC IMMUNOLOGY, 24 (1): (1-12). [PMID:38066482] |
2. Benjin Chen, Liang Xiao, Wanni Wang, Lingling Xu, Yechun Jiang, Guoqiang Zhang, Lin Liu, Xiaohu Li, Yongqiang Yu, Haisheng Qian. (2023) Bi2–xMnxO3 Nanospheres Engaged Radiotherapy with Amplifying DNA Damage. ACS Applied Materials & Interfaces, 15 (28): (33903–33915). [PMID:37410709] |
3. Zhiguo Wu, Yuchan Wu, Weicheng Zhong, Qingmei Zhong, Shengfang Rao, Dongshan Yu, Xiaolu Luo, Fang Qiu, Zhiying Song, Di Jin, Maoxing Ai, Yu Lan, Gongchang Zhang, Shufeng Song, Baogang Xie, Shuilin Sun. (2023) The hepatoprotective effect of aspirin on carbon tetrachloride‑induced hepatic fibrosis via inhibition of TGFβ‑1 pathway and pro‑inflammatory cytokines IL‑1β and COX‑2 in rats. Experimental and Therapeutic Medicine, 25 (5): (1-7). [PMID:37114173] |
4. Yi Shi, Qian Wu, Yi Lu, Ling-Peng Meng, Xiao-Ling Xu, Xiao-Juan Wang, Wei Chen. (2023) Arginine-Glycine-Aspartic Acid-anchored Curcumin-based Nanotherapeutics Inhibit Pyroptosis-induced Cytokine Release Syndrome for In Vivo and In Vitro Sepsis Applications. CURRENT PHARMACEUTICAL DESIGN, 29 (4): ( 283–294). [PMID:36722481] |
5. Lihuang Wu, Yuqi Wang, Xinyue Zhao, Hongli Mao, Zhongwei Gu. (2023) Investigating the Biodegradation Mechanism of Poly(trimethylene carbonate): Macrophage-Mediated Erosion by Secreting Lipase. BIOMACROMOLECULES, 24 (2): (921–928). [PMID:36644840] |
6. Tingting Wu, Xushun Liu, Hanjun Chen, Ying Liu, Yu Cao. (2023) An in situ exosomal miRNA sensing biochip based on multi-branched localized catalytic hairpin assembly and photonic crystals. BIOSENSORS & BIOELECTRONICS, 222 (115013). [PMID:36529054] |
7. Ruohua Qu, Mi Chen, Jingfu Liu, Qiting Xie, Na Liu, Fei Ge. (2023) Blockage of ATPase-mediated energy supply inducing metabolic disturbances in algal cells under silver nanoparticles stress. Journal of Environmental Sciences, 131 (141). [PMID:37225375] |
8. Yan-Mei Zhang, Khas Erdene, Ya-Bo Zhao, Chang-Qing Li, Li Wang, Feng Tian, Chang-Jin Ao, Hai Jin. (2022) Role of white adipose tissue browning in cold seasonal acclimation in grazing Mongolian sheep (Ovis aries). JOURNAL OF THERMAL BIOLOGY, 109 (103333). [PMID:36195394] |
9. Changkai Zhou, Jing Gao, Haijun Qu, Long Xu, Bin Zhang, Qie Guo, Fanbo Jing. (2022) Anti-inflammatory Mechanism of Action of Benzoylmesaconine in Lipopolysaccharide-Stimulated RAW264.7 Cells. Evidence-based Complementary and Alternative Medicine, 2022 (7008907). [PMID:35873638] |
1. Cai Jing, Wu Hao, Wang Chenxing, Chen Yujiao, Zhang Dingli, Guan Shiwei, Fu Beilei, Jin Yingli, Qian Cao. (2023) Sec1 regulates intestinal mucosal immunity in a mouse model of inflammatory bowel disease. BMC IMMUNOLOGY, 24 (1): (1-12). [PMID:38066482] |
2. Benjin Chen, Liang Xiao, Wanni Wang, Lingling Xu, Yechun Jiang, Guoqiang Zhang, Lin Liu, Xiaohu Li, Yongqiang Yu, Haisheng Qian. (2023) Bi2–xMnxO3 Nanospheres Engaged Radiotherapy with Amplifying DNA Damage. ACS Applied Materials & Interfaces, 15 (28): (33903–33915). [PMID:37410709] |
3. Zhiguo Wu, Yuchan Wu, Weicheng Zhong, Qingmei Zhong, Shengfang Rao, Dongshan Yu, Xiaolu Luo, Fang Qiu, Zhiying Song, Di Jin, Maoxing Ai, Yu Lan, Gongchang Zhang, Shufeng Song, Baogang Xie, Shuilin Sun. (2023) The hepatoprotective effect of aspirin on carbon tetrachloride‑induced hepatic fibrosis via inhibition of TGFβ‑1 pathway and pro‑inflammatory cytokines IL‑1β and COX‑2 in rats. Experimental and Therapeutic Medicine, 25 (5): (1-7). [PMID:37114173] |
4. Yi Shi, Qian Wu, Yi Lu, Ling-Peng Meng, Xiao-Ling Xu, Xiao-Juan Wang, Wei Chen. (2023) Arginine-Glycine-Aspartic Acid-anchored Curcumin-based Nanotherapeutics Inhibit Pyroptosis-induced Cytokine Release Syndrome for In Vivo and In Vitro Sepsis Applications. CURRENT PHARMACEUTICAL DESIGN, 29 (4): ( 283–294). [PMID:36722481] |
5. Lihuang Wu, Yuqi Wang, Xinyue Zhao, Hongli Mao, Zhongwei Gu. (2023) Investigating the Biodegradation Mechanism of Poly(trimethylene carbonate): Macrophage-Mediated Erosion by Secreting Lipase. BIOMACROMOLECULES, 24 (2): (921–928). [PMID:36644840] |
6. Tingting Wu, Xushun Liu, Hanjun Chen, Ying Liu, Yu Cao. (2023) An in situ exosomal miRNA sensing biochip based on multi-branched localized catalytic hairpin assembly and photonic crystals. BIOSENSORS & BIOELECTRONICS, 222 (115013). [PMID:36529054] |
7. Ruohua Qu, Mi Chen, Jingfu Liu, Qiting Xie, Na Liu, Fei Ge. (2023) Blockage of ATPase-mediated energy supply inducing metabolic disturbances in algal cells under silver nanoparticles stress. Journal of Environmental Sciences, 131 (141). [PMID:37225375] |
8. Yan-Mei Zhang, Khas Erdene, Ya-Bo Zhao, Chang-Qing Li, Li Wang, Feng Tian, Chang-Jin Ao, Hai Jin. (2022) Role of white adipose tissue browning in cold seasonal acclimation in grazing Mongolian sheep (Ovis aries). JOURNAL OF THERMAL BIOLOGY, 109 (103333). [PMID:36195394] |
9. Changkai Zhou, Jing Gao, Haijun Qu, Long Xu, Bin Zhang, Qie Guo, Fanbo Jing. (2022) Anti-inflammatory Mechanism of Action of Benzoylmesaconine in Lipopolysaccharide-Stimulated RAW264.7 Cells. Evidence-based Complementary and Alternative Medicine, 2022 (7008907). [PMID:35873638] |