Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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P105539-1g | 1g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $12.90 | |
P105539-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $39.90 | |
P105539-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $119.90 | |
P105539-100g | 100g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $307.90 |
Non-selective protease inhibitor; also blocks anandamide metabolism
Synonyms | PMSF | C06747 | P-4170 | PHENYLMETHYLSULFONYL-FLUORIDE | PMSF | HMS3656J16 | NCI60_041962 | EINECS 206-350-2 | alpha-TOLUENESULFONYL FLUORIDE | BDBM50171289 | BRN 2088311 | DTXSID6059819 | Phenylmethanesulfonyl fluoride, >=99.0% (T) | 3-11-00-00331 (Beils |
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Specifications & Purity | ≥98%(GC) |
Biochemical and Physiological Mechanisms | Non-selective protease inhibitor; irreversibly sulfonates key active site serine residues in serine proteases, acetylcholinesterases, and thiol proteases. Blocks metabolism of anandamidein a rodent model of cannabimimetic activity. Unstable in water (t1/2 |
Storage Temp | Store at 2-8°C,Argon charged |
Shipped In | Wet ice |
Product Description | Trypsin and chymotrypsin inhibitor.Potentiates the effects of ischemia on brain mitochondria through its inhibition of phospholipase C. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | phenylmethanesulfonyl fluoride |
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INCHI | InChI=1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2 |
InChi Key | YBYRMVIVWMBXKQ-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C(C=C1)CS(=O)(=O)F |
Isomeric SMILES | C1=CC=C(C=C1)CS(=O)(=O)F |
WGK Germany | 3 |
RTECS | XT8040000 |
PubChem CID | 4784 |
UN Number | 2928 |
Molecular Weight | 174.19 |
Beilstein | 2088311 |
Reaxy-Rn | 2088311 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
K2408469 | Certificate of Analysis | Oct 30, 2024 | P105539 |
K2408468 | Certificate of Analysis | Oct 30, 2024 | P105539 |
K2408467 | Certificate of Analysis | Oct 30, 2024 | P105539 |
K2408466 | Certificate of Analysis | Oct 30, 2024 | P105539 |
H2308457 | Certificate of Analysis | Feb 10, 2023 | P105539 |
H2308448 | Certificate of Analysis | Feb 10, 2023 | P105539 |
E2406040 | Certificate of Analysis | Feb 10, 2023 | P105539 |
H2308420 | Certificate of Analysis | Feb 10, 2023 | P105539 |
L2313042 | Certificate of Analysis | Nov 11, 2022 | P105539 |
A2303662 | Certificate of Analysis | Nov 11, 2022 | P105539 |
A2303651 | Certificate of Analysis | Nov 11, 2022 | P105539 |
A2303646 | Certificate of Analysis | Nov 11, 2022 | P105539 |
A2303645 | Certificate of Analysis | Nov 11, 2022 | P105539 |
G2230373 | Certificate of Analysis | Jun 25, 2022 | P105539 |
G2230374 | Certificate of Analysis | Jun 25, 2022 | P105539 |
G2230369 | Certificate of Analysis | Jun 25, 2022 | P105539 |
J2429076 | Certificate of Analysis | Jun 25, 2022 | P105539 |
J2429077 | Certificate of Analysis | Jun 25, 2022 | P105539 |
J2429078 | Certificate of Analysis | Jun 25, 2022 | P105539 |
A2203582 | Certificate of Analysis | Dec 17, 2021 | P105539 |
A2203581 | Certificate of Analysis | Dec 17, 2021 | P105539 |
A2203580 | Certificate of Analysis | Dec 17, 2021 | P105539 |
Solubility | Solvent:ethanol, Max Conc. mg/mL: 17.42, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 17.42, Max Conc. mM: 100 |
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Sensitivity | Moisture Sensitive |
Boil Point(°C) | 85°C/0.3mmHg |
Melt Point(°C) | 92-95°C |
Pictogram(s) | GHS06, GHS05 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed H314:Causes severe skin burns and eye damage |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. |
WGK Germany | 3 |
RTECS | XT8040000 |
Reaxy-Rn | 2088311 |
Merck Index | 7542 |
Starting at $35.90
Starting at $161.90
1. Cai Jing, Wu Hao, Wang Chenxing, Chen Yujiao, Zhang Dingli, Guan Shiwei, Fu Beilei, Jin Yingli, Qian Cao. (2023) Sec1 regulates intestinal mucosal immunity in a mouse model of inflammatory bowel disease. BMC IMMUNOLOGY, 24 (1): (1-12). [PMID:38066482] [10.1186/s12865-023-00578-9] |
2. Benjin Chen, Liang Xiao, Wanni Wang, Lingling Xu, Yechun Jiang, Guoqiang Zhang, Lin Liu, Xiaohu Li, Yongqiang Yu, Haisheng Qian. (2023) Bi2–xMnxO3 Nanospheres Engaged Radiotherapy with Amplifying DNA Damage. ACS Applied Materials & Interfaces, 15 (28): (33903–33915). [PMID:37410709] [10.1021/acsami.3c06838] |
3. Zhiguo Wu, Yuchan Wu, Weicheng Zhong, Qingmei Zhong, Shengfang Rao, Dongshan Yu, Xiaolu Luo, Fang Qiu, Zhiying Song, Di Jin, Maoxing Ai, Yu Lan, Gongchang Zhang, Shufeng Song, Baogang Xie, Shuilin Sun. (2023) The hepatoprotective effect of aspirin on carbon tetrachloride‑induced hepatic fibrosis via inhibition of TGFβ‑1 pathway and pro‑inflammatory cytokines IL‑1β and COX‑2 in rats. Experimental and Therapeutic Medicine, 25 (5): (1-7). [PMID:37114173] [10.3892/etm.2023.11931] |
4. Yi Shi, Qian Wu, Yi Lu, Ling-Peng Meng, Xiao-Ling Xu, Xiao-Juan Wang, Wei Chen. (2023) Arginine-Glycine-Aspartic Acid-anchored Curcumin-based Nanotherapeutics Inhibit Pyroptosis-induced Cytokine Release Syndrome for In Vivo and In Vitro Sepsis Applications. CURRENT PHARMACEUTICAL DESIGN, 29 (4): ( 283–294). [PMID:36722481] [10.2174/1381612829666230201144029] |
5. Lihuang Wu, Yuqi Wang, Xinyue Zhao, Hongli Mao, Zhongwei Gu. (2023) Investigating the Biodegradation Mechanism of Poly(trimethylene carbonate): Macrophage-Mediated Erosion by Secreting Lipase. BIOMACROMOLECULES, 24 (2): (921–928). [PMID:36644840] [10.1021/acs.biomac.2c01350] |
6. Tingting Wu, Xushun Liu, Hanjun Chen, Ying Liu, Yu Cao. (2023) An in situ exosomal miRNA sensing biochip based on multi-branched localized catalytic hairpin assembly and photonic crystals. BIOSENSORS & BIOELECTRONICS, 222 (115013). [PMID:36529054] [10.1016/j.bios.2022.115013] |
7. Ruohua Qu, Mi Chen, Jingfu Liu, Qiting Xie, Na Liu, Fei Ge. (2023) Blockage of ATPase-mediated energy supply inducing metabolic disturbances in algal cells under silver nanoparticles stress. Journal of Environmental Sciences, 131 (141). [PMID:37225375] [10.1016/j.jes.2022.10.029] |
8. Yan-Mei Zhang, Khas Erdene, Ya-Bo Zhao, Chang-Qing Li, Li Wang, Feng Tian, Chang-Jin Ao, Hai Jin. (2022) Role of white adipose tissue browning in cold seasonal acclimation in grazing Mongolian sheep (Ovis aries). JOURNAL OF THERMAL BIOLOGY, 109 (103333). [PMID:36195394] [10.1016/j.jtherbio.2022.103333] |
9. Changkai Zhou, Jing Gao, Haijun Qu, Long Xu, Bin Zhang, Qie Guo, Fanbo Jing. (2022) Anti-inflammatory Mechanism of Action of Benzoylmesaconine in Lipopolysaccharide-Stimulated RAW264.7 Cells. Evidence-based Complementary and Alternative Medicine, 2022 (7008907). [PMID:35873638] [10.1155/2022/7008907] |
10. Zhou Changkai, Gao Jing, Ji Hongyan, Li Wenjing, Xing Xiaomin, Liu Donghua, Guo Qie, Zhou Lihua, Jing Fanbo. (2021) Benzoylaconine Modulates LPS-Induced Responses Through Inhibition of Toll-Like Receptor-Mediated NF-κB and MAPK Signaling in RAW264.7 Cells. INFLAMMATION, 44 (5): (2018-2032). [PMID:34272638] [10.1007/s10753-021-01478-z] |
11. Yini Pan, Chenhui Zhang, Ruili Xiao, Lingyi Zhang, Weibing Zhang. (2021) Dual-functionalized magnetic bimetallic metal-organic framework composite for highly specific enrichments of phosphopeptides and glycopeptides. ANALYTICA CHIMICA ACTA, 1158 (338412). [PMID:33863420] [10.1016/j.aca.2021.338412] |
12. Miao Liu, Wenjie Xie, Xinyue Wan, Tao Deng. (2020) Clostridium butyricum protects intestinal barrier function via upregulation of tight junction proteins and activation of the Akt/mTOR signaling pathway in a mouse model of dextran sodium sulfate‑induced colitis. Experimental and Therapeutic Medicine, 20 (5): (1-1). [PMID:32934675] [10.3892/etm.2020.9138] |
13. Guojun Yang, Wei Chen, Haidong Tan, Kuikui Li, Junyan Li, Heng Yin. (2020) Biochemical characterization and evolutionary analysis of a novel pectate lyase from Aspergillus parasiticus. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 152 (180). [PMID:32109469] [10.1016/j.ijbiomac.2020.02.279] |
14. Yin Yi-Rui, Sang Peng, Xiao Min, Xian Wen-Dong, Dong Zhou-Yan, Liu Lan, Yang Li-Quan, Li Wen-Jun. (2021) Expression and characterization of a cold-adapted, salt- and glucose-tolerant GH1 β-glucosidase obtained from Thermobifida halotolerans and its use in sugarcane bagasse hydrolysis. Biomass Conversion and Biorefinery, 11 (4): (1245-1253). [PMID:] [10.1007/s13399-019-00556-5] |
15. Na Liu, Han Zhang, Jinfeng Zhao, Yin Xu, Fei Ge. (2020) Mechanisms of cetyltrimethyl ammonium chloride-induced toxicity to photosystem II oxygen evolution complex of Chlorella vulgaris F1068. JOURNAL OF HAZARDOUS MATERIALS, 383 (121063). [PMID:31539660] [10.1016/j.jhazmat.2019.121063] |
16. Jing Jin, Qiao‑Yun Hu, Wen‑Wen Xu, Wen‑Jia Zhu, Bei Liu, Jing Liu, Wei Wang, Hui‑Fang Zhou. (2019) Tanshinone IIA attenuates estradiol‑induced polycystic ovarian syndrome in mice by ameliorating FSHR expression in the ovary. Experimental and Therapeutic Medicine, 17 (5): (3501-3508). [PMID:30988730] [10.3892/etm.2019.7352] |
17. Juan Wang, Mengmeng Song, Chengguo Hu, Kangbing Wu. (2018) Portable, Self-Powered, and Light-Addressable Photoelectrochemical Sensing Platforms Using pH Meter Readouts for High-Throughput Screening of Thrombin Inhibitor Drugs. ANALYTICAL CHEMISTRY, 90 (15): (9366–9373). [PMID:29998727] [10.1021/acs.analchem.8b01979] |
18. Xiaoli Gu, Jiaojiao Huang, Lei Zhang, Yu Zhang, Chong-Zhi Wang, Chenghong Sun, Dandan Yao, Fei Li, Lina Chen, Chun-Su Yuan. (2017) Efficient discovery and capture of new neuronal nitric oxide synthase–postsynaptic density protein-95 uncouplers from herbal medicines using magnetic molecularly imprinted polymers as artificial antibodies. JOURNAL OF SEPARATION SCIENCE, 40 (17): (3522-3534). [PMID:28704580] [10.1002/jssc.201700595] |
19. Cong Luo, Jin Sun, Bingjun Sun, Dan Liu, Lei Miao, Tyler Jay Goodwin, Leaf Huang, Zhonggui He. (2016) Facile Fabrication of Tumor Redox-Sensitive Nanoassemblies of Small-Molecule Oleate Prodrug as Potent Chemotherapeutic Nanomedicine. Small, 12 (46): (6353-6362). [PMID:27689847] [10.1002/smll.201601597] |
20. Peng Xue, Dan Liu, Jing Wang, Na Zhang, Jiahua Zhou, Lin Li, Weiling Guo, Mengchi Sun, Xiangfei Han, Yongjun Wang. (2016) Redox-Sensitive Citronellol–Cabazitaxel Conjugate: Maintained in Vitro Cytotoxicity and Self-Assembled as Multifunctional Nanomedicine. BIOCONJUGATE CHEMISTRY, 27 (5): (1360–1372). [PMID:27070505] [10.1021/acs.bioconjchem.6b00155] |
21. Lili Zhao, Shuhua Zhu, Jie Zhou. (2012) A novel amperometric nitric oxide sensor based on imprinted microenvironments for controlling metal coordination. SENSORS AND ACTUATORS B-CHEMICAL, 171-172 (563). [PMID:] [10.1016/j.snb.2012.05.035] |
1. Cai Jing, Wu Hao, Wang Chenxing, Chen Yujiao, Zhang Dingli, Guan Shiwei, Fu Beilei, Jin Yingli, Qian Cao. (2023) Sec1 regulates intestinal mucosal immunity in a mouse model of inflammatory bowel disease. BMC IMMUNOLOGY, 24 (1): (1-12). [PMID:38066482] [10.1186/s12865-023-00578-9] |
2. Benjin Chen, Liang Xiao, Wanni Wang, Lingling Xu, Yechun Jiang, Guoqiang Zhang, Lin Liu, Xiaohu Li, Yongqiang Yu, Haisheng Qian. (2023) Bi2–xMnxO3 Nanospheres Engaged Radiotherapy with Amplifying DNA Damage. ACS Applied Materials & Interfaces, 15 (28): (33903–33915). [PMID:37410709] [10.1021/acsami.3c06838] |
3. Zhiguo Wu, Yuchan Wu, Weicheng Zhong, Qingmei Zhong, Shengfang Rao, Dongshan Yu, Xiaolu Luo, Fang Qiu, Zhiying Song, Di Jin, Maoxing Ai, Yu Lan, Gongchang Zhang, Shufeng Song, Baogang Xie, Shuilin Sun. (2023) The hepatoprotective effect of aspirin on carbon tetrachloride‑induced hepatic fibrosis via inhibition of TGFβ‑1 pathway and pro‑inflammatory cytokines IL‑1β and COX‑2 in rats. Experimental and Therapeutic Medicine, 25 (5): (1-7). [PMID:37114173] [10.3892/etm.2023.11931] |
4. Yi Shi, Qian Wu, Yi Lu, Ling-Peng Meng, Xiao-Ling Xu, Xiao-Juan Wang, Wei Chen. (2023) Arginine-Glycine-Aspartic Acid-anchored Curcumin-based Nanotherapeutics Inhibit Pyroptosis-induced Cytokine Release Syndrome for In Vivo and In Vitro Sepsis Applications. CURRENT PHARMACEUTICAL DESIGN, 29 (4): ( 283–294). [PMID:36722481] [10.2174/1381612829666230201144029] |
5. Lihuang Wu, Yuqi Wang, Xinyue Zhao, Hongli Mao, Zhongwei Gu. (2023) Investigating the Biodegradation Mechanism of Poly(trimethylene carbonate): Macrophage-Mediated Erosion by Secreting Lipase. BIOMACROMOLECULES, 24 (2): (921–928). [PMID:36644840] [10.1021/acs.biomac.2c01350] |
6. Tingting Wu, Xushun Liu, Hanjun Chen, Ying Liu, Yu Cao. (2023) An in situ exosomal miRNA sensing biochip based on multi-branched localized catalytic hairpin assembly and photonic crystals. BIOSENSORS & BIOELECTRONICS, 222 (115013). [PMID:36529054] [10.1016/j.bios.2022.115013] |
7. Ruohua Qu, Mi Chen, Jingfu Liu, Qiting Xie, Na Liu, Fei Ge. (2023) Blockage of ATPase-mediated energy supply inducing metabolic disturbances in algal cells under silver nanoparticles stress. Journal of Environmental Sciences, 131 (141). [PMID:37225375] [10.1016/j.jes.2022.10.029] |
8. Yan-Mei Zhang, Khas Erdene, Ya-Bo Zhao, Chang-Qing Li, Li Wang, Feng Tian, Chang-Jin Ao, Hai Jin. (2022) Role of white adipose tissue browning in cold seasonal acclimation in grazing Mongolian sheep (Ovis aries). JOURNAL OF THERMAL BIOLOGY, 109 (103333). [PMID:36195394] [10.1016/j.jtherbio.2022.103333] |
9. Changkai Zhou, Jing Gao, Haijun Qu, Long Xu, Bin Zhang, Qie Guo, Fanbo Jing. (2022) Anti-inflammatory Mechanism of Action of Benzoylmesaconine in Lipopolysaccharide-Stimulated RAW264.7 Cells. Evidence-based Complementary and Alternative Medicine, 2022 (7008907). [PMID:35873638] [10.1155/2022/7008907] |
10. Zhou Changkai, Gao Jing, Ji Hongyan, Li Wenjing, Xing Xiaomin, Liu Donghua, Guo Qie, Zhou Lihua, Jing Fanbo. (2021) Benzoylaconine Modulates LPS-Induced Responses Through Inhibition of Toll-Like Receptor-Mediated NF-κB and MAPK Signaling in RAW264.7 Cells. INFLAMMATION, 44 (5): (2018-2032). [PMID:34272638] [10.1007/s10753-021-01478-z] |
11. Yini Pan, Chenhui Zhang, Ruili Xiao, Lingyi Zhang, Weibing Zhang. (2021) Dual-functionalized magnetic bimetallic metal-organic framework composite for highly specific enrichments of phosphopeptides and glycopeptides. ANALYTICA CHIMICA ACTA, 1158 (338412). [PMID:33863420] [10.1016/j.aca.2021.338412] |
12. Miao Liu, Wenjie Xie, Xinyue Wan, Tao Deng. (2020) Clostridium butyricum protects intestinal barrier function via upregulation of tight junction proteins and activation of the Akt/mTOR signaling pathway in a mouse model of dextran sodium sulfate‑induced colitis. Experimental and Therapeutic Medicine, 20 (5): (1-1). [PMID:32934675] [10.3892/etm.2020.9138] |
13. Guojun Yang, Wei Chen, Haidong Tan, Kuikui Li, Junyan Li, Heng Yin. (2020) Biochemical characterization and evolutionary analysis of a novel pectate lyase from Aspergillus parasiticus. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 152 (180). [PMID:32109469] [10.1016/j.ijbiomac.2020.02.279] |
14. Yin Yi-Rui, Sang Peng, Xiao Min, Xian Wen-Dong, Dong Zhou-Yan, Liu Lan, Yang Li-Quan, Li Wen-Jun. (2021) Expression and characterization of a cold-adapted, salt- and glucose-tolerant GH1 β-glucosidase obtained from Thermobifida halotolerans and its use in sugarcane bagasse hydrolysis. Biomass Conversion and Biorefinery, 11 (4): (1245-1253). [PMID:] [10.1007/s13399-019-00556-5] |
15. Na Liu, Han Zhang, Jinfeng Zhao, Yin Xu, Fei Ge. (2020) Mechanisms of cetyltrimethyl ammonium chloride-induced toxicity to photosystem II oxygen evolution complex of Chlorella vulgaris F1068. JOURNAL OF HAZARDOUS MATERIALS, 383 (121063). [PMID:31539660] [10.1016/j.jhazmat.2019.121063] |
16. Jing Jin, Qiao‑Yun Hu, Wen‑Wen Xu, Wen‑Jia Zhu, Bei Liu, Jing Liu, Wei Wang, Hui‑Fang Zhou. (2019) Tanshinone IIA attenuates estradiol‑induced polycystic ovarian syndrome in mice by ameliorating FSHR expression in the ovary. Experimental and Therapeutic Medicine, 17 (5): (3501-3508). [PMID:30988730] [10.3892/etm.2019.7352] |
17. Juan Wang, Mengmeng Song, Chengguo Hu, Kangbing Wu. (2018) Portable, Self-Powered, and Light-Addressable Photoelectrochemical Sensing Platforms Using pH Meter Readouts for High-Throughput Screening of Thrombin Inhibitor Drugs. ANALYTICAL CHEMISTRY, 90 (15): (9366–9373). [PMID:29998727] [10.1021/acs.analchem.8b01979] |
18. Xiaoli Gu, Jiaojiao Huang, Lei Zhang, Yu Zhang, Chong-Zhi Wang, Chenghong Sun, Dandan Yao, Fei Li, Lina Chen, Chun-Su Yuan. (2017) Efficient discovery and capture of new neuronal nitric oxide synthase–postsynaptic density protein-95 uncouplers from herbal medicines using magnetic molecularly imprinted polymers as artificial antibodies. JOURNAL OF SEPARATION SCIENCE, 40 (17): (3522-3534). [PMID:28704580] [10.1002/jssc.201700595] |
19. Cong Luo, Jin Sun, Bingjun Sun, Dan Liu, Lei Miao, Tyler Jay Goodwin, Leaf Huang, Zhonggui He. (2016) Facile Fabrication of Tumor Redox-Sensitive Nanoassemblies of Small-Molecule Oleate Prodrug as Potent Chemotherapeutic Nanomedicine. Small, 12 (46): (6353-6362). [PMID:27689847] [10.1002/smll.201601597] |
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