Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P127748-250mg | 250mg | In stock | $53.90 | |
P127748-1g | 1g | In stock | $194.90 | |
P127748-5g | 5g | In stock | $874.90 | |
P127748-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $3,936.90 | |
P127748-100g | 100g | In stock | $14,171.90 |
Dihydrochalcones flavonoid
Synonyms | phloretin | 60-82-2 | Dihydronaringenin | 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one | Phloretol | 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone | NSC 407292 | 1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)- | MFCD00002288 | beta-( |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Phloretin is an inhibitor of calcium channel protein, MCT1, MCT2, and PKC. It is the major polyphenol found in apple.Dihydrochalcones flavonoid. GLUT inhibitor. Active phlorizin metabolite. Blocks L-type Ca 2+ channels. Activates Ca 2+ -activated K + chan |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | AGONIST, CHANNEL BLOCKER, INHIBITOR |
Mechanism of action | Inhibitor of AQP9;Channel blocker of ClC-3;Agonist of TAS2R14;Agonist of TAS2R39;Inhibitor of major facilitator superfamily domain containing 4B;Inhibitor of Sodium-dependent vitamin C transporter 1 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Phloretin is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes. |
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IUPAC Name | 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one |
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INCHI | InChI=1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2 |
InChi Key | VGEREEWJJVICBM-UHFFFAOYSA-N |
Canonical SMILES | C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O)O)O |
Isomeric SMILES | C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O)O)O |
WGK Germany | 3 |
PubChem CID | 4788 |
Molecular Weight | 274.27 |
Beilstein | 1887240 |
Reaxy-Rn | 1887240 |
DrugBank Ligand | DB07810 |
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Wikipedia | Phloretin |
CAS Registry No. | 60-82-2 |
PubChem CID | 4788 |
ChEBI | CHEBI:17276 |
ChEMBL Ligand | CHEMBL45068 |
BitterDB Ligand | 909 |
RCSB PDB Ligand | G50 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
J2210680 | Certificate of Analysis | Aug 14, 2024 | P127748 |
H2405013 | Certificate of Analysis | Aug 13, 2024 | P127748 |
J2210661 | Certificate of Analysis | Jul 11, 2024 | P127748 |
J2210662 | Certificate of Analysis | Jul 11, 2024 | P127748 |
J2210681 | Certificate of Analysis | Jul 11, 2024 | P127748 |
E2224117 | Certificate of Analysis | Mar 20, 2024 | P127748 |
H2124477 | Certificate of Analysis | Jun 07, 2023 | P127748 |
H2124478 | Certificate of Analysis | Jun 07, 2023 | P127748 |
A2403030 | Certificate of Analysis | Jul 23, 2022 | P127748 |
C2419221 | Certificate of Analysis | Jul 23, 2022 | P127748 |
E2224255 | Certificate of Analysis | Mar 21, 2022 | P127748 |
E2224260 | Certificate of Analysis | Mar 21, 2022 | P127748 |
Solubility | Soluble in ethanol, methanol, acetone, hot glacial acetic acid, alkalies, benzene (sparingly soluble), chloroform (sparingly soluble), and DMSO. Insoluble in water, and ether. |
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Sensitivity | Light & Heat sensitive |
Melt Point(°C) | 262°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
Reaxy-Rn | 1887240 |
Merck Index | 7326 |
1. Meng Zhang, Xue Zhuang, Siqi Li, Yansong Wang, Xiangyu Zhang, Jinlian Li, Dongmei Wu. (2024) Designed Fabrication of Phloretin-Loaded Propylene Glycol Binary Ethosomes: Stability, Skin Permeability and Antioxidant Activity. MOLECULES, 29 (1): (66). [PMID:38202649] |
2. Yu Hu, Hui Guo, Shuai Cheng, Junpeng Sun, Jiaqun Du, Xiaobang Liu, Ying Xiong, Liqing Chen, Chang Liu, Chao Wu, He Tian. (2023) Functionalized Cerium Dioxide Nanoparticles with Antioxidative Neuroprotection for Alzheimer’s Disease. International Journal of Nanomedicine, [PMID:38026525] |
3. Hong Hu, Liang Chen, Ying Huang, Kunping Wang, Xi Bai, Hongbin Pan. (2023) CUT&tag-seq analysis of heat stress response in broiler liver provides novel insights into the improved thermotolerance by dietary phloretin. ANNALS OF AGRICULTURAL SCIENCE, 68 (12). [PMID:] |
4. Wang Jie, Jia Jingyu, Sun Jiaju, Pang Xinyue, Li Bairu, Yuan Jiangfeng, Chen Enyan, Li Xin. (2023) Trypsin preservation: CsUGT91C1 regulates Trilobatin Biosynthesis in Cucumis sativus during Storage. PLANT GROWTH REGULATION, 100 (3): (633-646). [PMID:] |
5. Yang Liu, Jiali Lin, Tiantian Cheng, Yangjie Liu, Fuliang Han. (2022) Methylation, Hydroxylation, Glycosylation and Acylation Affect the Transport of Wine Anthocyanins in Caco-2 Cells. Foods, 11 (23): (3793). [PMID:36496602] |
6. Mile Li, Mengyi Wang, Shuhui Hu, Jing Sun, Mingqiang Zhu, Yongsheng Ni, Jianlong Wang. (2022) Advanced Coatings with Antioxidant and Antibacterial Activity for Kumquat Preservation. Foods, 11 (15): (2363). [PMID:35954129] |
7. Yingqiao Li, Zhiru Zou, Jinyu An, Qian Wu, Le Tong, Xifan Mei, He Tian, Chao Wu. (2022) Chitosan-modified hollow manganese dioxide nanoparticles loaded with resveratrol for the treatment of spinal cord injury. DRUG DELIVERY, 29 (1): (2498-2512). [PMID:35903814] |
8. Zhang Guorong, Wang Qin, Tao Wanyin, Jiang Wei, Elinav Eran, Wang Yucai, Zhu Shu. (2022) Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis. Nature Biomedical Engineering, 6 (7): (867-881). [PMID:35798834] |
9. Fang Li, Yachao Xi, Jianming Jiang, Hao Peng, Bing Li, Jianbo He, Jiangnan Shu, Hua Cui. (2022) O-Fluorobenzoic Acid-Mediated Construction of Porous Graphitic Carbon Nitride with Nitrogen Defects for Multicolor Electrochemiluminescence Imaging Sensing. ANALYTICAL CHEMISTRY, 94 (26): (9306–9315). [PMID:35738019] |
10. Zhiru Zou, Shan Wen, Yingqiao Li, Jinyu An, Qian Wu, Le Tong, Xifan Mei, He Tian, Chao Wu. (2022) Novel lactoferrin-functionalized manganese-doped silica hollow mesoporous nanoparticles loaded with resveratrol for the treatment of ischemic stroke. Materials Today Advances, 15 (100262). [PMID:] |
11. Zhang Pengpeng, Zhang Miaomiao, Dong Kaiyu, Zhang Yicong, Yang Shuang, Wang Yuanhong, Jiang Tingfu, Yu Mingming, Lv Zhihua. (2022) Evaluation of Chito-Oligosaccharide (COS) in Vitro and in Vivo: Permeability Characterization in Caco-2 Cells Monolayer and Pharmacokinetics Properties in Rats. Journal of Ocean University of China, 21 (3): (782-788). [PMID:] |
12. Wu Wanbao, Bo Yiyang, Li Deping, Liang Yihong, Zhang Jichuan, Cao Miaomiao, Guo Ruitian, Zhu Zhenye, Ci Lijie, Li Mingyu, Zhang Jiaheng. (2022) Safe and Stable Lithium Metal Batteries Enabled by an Amide-Based Electrolyte. Nano-Micro Letters, 14 (1): (1-14). [PMID:35020069] |
13. Xue Jiang, Xiaoyao Liu, Qi Yu, Wenwen Shen, Xifan Mei, He Tian, Chao Wu. (2022) Functional resveratrol-biodegradable manganese doped silica nanoparticles for the spinal cord injury treatment. Materials Today Bio, 13 (100177). [PMID:34938991] |
1. Meng Zhang, Xue Zhuang, Siqi Li, Yansong Wang, Xiangyu Zhang, Jinlian Li, Dongmei Wu. (2024) Designed Fabrication of Phloretin-Loaded Propylene Glycol Binary Ethosomes: Stability, Skin Permeability and Antioxidant Activity. MOLECULES, 29 (1): (66). [PMID:38202649] |
2. Yu Hu, Hui Guo, Shuai Cheng, Junpeng Sun, Jiaqun Du, Xiaobang Liu, Ying Xiong, Liqing Chen, Chang Liu, Chao Wu, He Tian. (2023) Functionalized Cerium Dioxide Nanoparticles with Antioxidative Neuroprotection for Alzheimer’s Disease. International Journal of Nanomedicine, [PMID:38026525] |
3. Hong Hu, Liang Chen, Ying Huang, Kunping Wang, Xi Bai, Hongbin Pan. (2023) CUT&tag-seq analysis of heat stress response in broiler liver provides novel insights into the improved thermotolerance by dietary phloretin. ANNALS OF AGRICULTURAL SCIENCE, 68 (12). [PMID:] |
4. Wang Jie, Jia Jingyu, Sun Jiaju, Pang Xinyue, Li Bairu, Yuan Jiangfeng, Chen Enyan, Li Xin. (2023) Trypsin preservation: CsUGT91C1 regulates Trilobatin Biosynthesis in Cucumis sativus during Storage. PLANT GROWTH REGULATION, 100 (3): (633-646). [PMID:] |
5. Yang Liu, Jiali Lin, Tiantian Cheng, Yangjie Liu, Fuliang Han. (2022) Methylation, Hydroxylation, Glycosylation and Acylation Affect the Transport of Wine Anthocyanins in Caco-2 Cells. Foods, 11 (23): (3793). [PMID:36496602] |
6. Mile Li, Mengyi Wang, Shuhui Hu, Jing Sun, Mingqiang Zhu, Yongsheng Ni, Jianlong Wang. (2022) Advanced Coatings with Antioxidant and Antibacterial Activity for Kumquat Preservation. Foods, 11 (15): (2363). [PMID:35954129] |
7. Yingqiao Li, Zhiru Zou, Jinyu An, Qian Wu, Le Tong, Xifan Mei, He Tian, Chao Wu. (2022) Chitosan-modified hollow manganese dioxide nanoparticles loaded with resveratrol for the treatment of spinal cord injury. DRUG DELIVERY, 29 (1): (2498-2512). [PMID:35903814] |
8. Zhang Guorong, Wang Qin, Tao Wanyin, Jiang Wei, Elinav Eran, Wang Yucai, Zhu Shu. (2022) Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis. Nature Biomedical Engineering, 6 (7): (867-881). [PMID:35798834] |
9. Fang Li, Yachao Xi, Jianming Jiang, Hao Peng, Bing Li, Jianbo He, Jiangnan Shu, Hua Cui. (2022) O-Fluorobenzoic Acid-Mediated Construction of Porous Graphitic Carbon Nitride with Nitrogen Defects for Multicolor Electrochemiluminescence Imaging Sensing. ANALYTICAL CHEMISTRY, 94 (26): (9306–9315). [PMID:35738019] |
10. Zhiru Zou, Shan Wen, Yingqiao Li, Jinyu An, Qian Wu, Le Tong, Xifan Mei, He Tian, Chao Wu. (2022) Novel lactoferrin-functionalized manganese-doped silica hollow mesoporous nanoparticles loaded with resveratrol for the treatment of ischemic stroke. Materials Today Advances, 15 (100262). [PMID:] |
11. Zhang Pengpeng, Zhang Miaomiao, Dong Kaiyu, Zhang Yicong, Yang Shuang, Wang Yuanhong, Jiang Tingfu, Yu Mingming, Lv Zhihua. (2022) Evaluation of Chito-Oligosaccharide (COS) in Vitro and in Vivo: Permeability Characterization in Caco-2 Cells Monolayer and Pharmacokinetics Properties in Rats. Journal of Ocean University of China, 21 (3): (782-788). [PMID:] |
12. Wu Wanbao, Bo Yiyang, Li Deping, Liang Yihong, Zhang Jichuan, Cao Miaomiao, Guo Ruitian, Zhu Zhenye, Ci Lijie, Li Mingyu, Zhang Jiaheng. (2022) Safe and Stable Lithium Metal Batteries Enabled by an Amide-Based Electrolyte. Nano-Micro Letters, 14 (1): (1-14). [PMID:35020069] |
13. Xue Jiang, Xiaoyao Liu, Qi Yu, Wenwen Shen, Xifan Mei, He Tian, Chao Wu. (2022) Functional resveratrol-biodegradable manganese doped silica nanoparticles for the spinal cord injury treatment. Materials Today Bio, 13 (100177). [PMID:34938991] |