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Phloridzin - ≥98%, high purity , CAS No.60-81-1, Inhibitor of major facilitator superfamily domain containing 4B;Inhibitor of SGLT6;Inhibitor of SMIT
Potent, competitive SGLT inhibitor
Basic Description Synonyms Phlorizin|Phloridzin|60-81-1|Phlorhizin|Phlorizoside|Floridzin|Phlorrhizin|Phloretin 2'-glucoside|Phloridzinum|Phloridzosid|Phlorrhizen|Phlorizine|NSC 2833|Phloretin-2'-O-beta-glucoside|AI3-19835|EINECS 200-487-1|UNII-CU9S17279X|CHEBI:8113|Phlorizin hydra Specifications & Purity ≥98% Shipped In Normal Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of major facilitator superfamily domain containing 4B;Inhibitor of SGLT6;Inhibitor of SMIT Product Description Phloridzin is a dihydrochalcone found in all parts of the apple tree, except the mature fruit, and acts as an inhibitor of SGLT-1 and SGLT-2.
Names and Identifiers IUPAC Name 1-[2,4-dihydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-hydroxyphenyl)propan-1-one INCHI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1 InChi Key IOUVKUPGCMBWBT-QNDFHXLGSA-N Canonical SMILES C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2OC3C(C(C(C(O3)CO)O)O)O)O)O)O Isomeric SMILES C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O)O)O WGK Germany 3 PubChem CID 6072 Molecular Weight 436.45 Beilstein 66621
Chemical and Physical Properties Solubility Soluble in DMSO (100 mM), methanol, acetone, ethanol (100 mM), and water (partly). Refractive Index 1.69 Melt Point(°C) 113-114°C
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 3
References 1. Yang Liu, Jiali Lin, Tiantian Cheng, Yangjie Liu and Fuliang Han. (2022) Methylation, Hydroxylation, Glycosylation and Acylation Affect the Transport of Wine Anthocyanins in Caco-2 Cells. FOODS, 23 (11): (3793). [PMID:
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C2412392