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PHOP - A solution in methyl acetate, high purity , CAS No.288862-83-9
Basic Description Synonyms PHOP | 288862-83-9 | 1-Oxazolo[4,5-b]pyridin-2-yl-6-phenyl-hexan-1-one | CHEMBL175854 | 1-(oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one | 1-Hexanone, 1-oxazolo[4,5-b]pyridin-2-yl-6-phenyl- | 1-([1,3]oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one | 1-{[1,3]oxazolo[4 Specifications & Purity A solution in methyl acetate Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description Phenyl hexanoyl oxazolopyridine (PHOP) is a potent FAAH inhibitor (K|i|= 0.094 nM and 0.2 nM for the human and rat enzymes, respectively). Using a proteomics approach, PHOP was screened against the serine hydrolase family of enzymes, of which FAAH is a member. In this assay, PHOP exhibited IC|50|values of 1.1 nM, 1.4 nM, and >100 μM for FAAH, triacylglycerol hydrolase (TGH), and an uncharacterized hydrolase (KIAA1363), respectively. Knowledge of the specificity of PHOP obtained from this experiment should allow for more accurate interpretation of results using this inhibitor in complex environments such as whole cells or animals.
Product Properties Ki Data FAAH: Ki= 0.094 nM (human); FAAH: Ki= 0.2 nM (rat)
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 1-([1,3]oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one INCHI InChI=1S/C18H18N2O2/c21-15(18-20-17-16(22-18)12-7-13-19-17)11-6-2-5-10-14-8-3-1-4-9-14/h1,3-4,7-9,12-13H,2,5-6,10-11H2 InChi Key VPZHQLPAKFVGKX-UHFFFAOYSA-N Canonical SMILES C1=CC=C(C=C1)CCCCCC(=O)C2=NC3=C(O2)C=CC=N3 Isomeric SMILES C1=CC=C(C=C1)CCCCCC(=O)C2=NC3=C(O2)C=CC=N3 WGK Germany 3 PubChem CID 10085812 Molecular Weight 294.35
Chemical and Physical Properties Solubility Soluble in water (0.25 mg/ml at 25.0° C), DMSO: PBS(1:2) (pH 7.2) (~0.25 mg/ml), ethanol (~10 mg/ml), DMSO (~30 mg/ml), and DMF (~30 mg/ml). Refractive Index n20D1.60 (Predicted)
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H302: Harmful if swallowed
Precautionary Statements P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P317: IF SWALLOWED: Get medical help.
WGK Germany 3 RIDADR NONHforallmodesoftransport
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