Phorbol 12-myristate 13-acetate - 98%, high purity , CAS No.16561-29-8, Gating inhibitor of K ir3.4;Activator of K Na1.1;Gating inhibitor of K Na1.2;Activator of TRPV4

12 Citations
Item Number
P167764
Grouped product items
SKUSizeAvailabilityPrice Qty
P167764-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$58.90
P167764-5mg
5mg
In stock
$105.90
P167764-10mg
10mg
In stock
$153.90
P167764-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$276.90
P167764-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$498.90

PKC activator

Basic Description

SynonymsPhorbol 12-myristate 13-acetate | 16561-29-8 | 12-O-Tetradecanoylphorbol-13-acetate | phorbol-12-myristate-13-acetate | 12-O-Tetradecanoylphorbol 13-acetate | Phorbol ester | Tetradecanoylphorbol acetate | Factor A1 | 12-Tetradecanoylphorbol 13-acetate | Phorbol myristate
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsPhobos 12 tetradecanoate 13 acetate is an effective tumor promoter that can activate protein kinase C both in vivo and in vitro. This is a type of phorbol ester that is associated with many cellular responses, including gene transcription, cell division a
Storage TempProtected from light,Store at -20°C,Argon charged
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeACTIVATOR, GATING INHIBITOR
Mechanism of actionGating inhibitor of K ir3.4;Activator of K Na1.1;Gating inhibitor of K Na1.2;Activator of TRPV4
NoteThis product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

RASGRP3 Tchem Ras guanyl-releasing protein 3 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TRPV4 Tchem Transient receptor potential cation channel subfamily V member 4 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PRKCD Tclin Protein kinase C delta type (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PRKCB Tchem Protein kinase C beta type (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PRKCE Tchem Protein kinase C epsilon type (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNJ5 Tchem G protein-activated inward rectifier potassium channel 4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNT1 Tchem Potassium channel subfamily T member 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNT2 Tchem Potassium channel subfamily T member 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PRKCG Tchem Protein kinase C gamma type (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PRKCA Tchem Protein kinase C alpha type (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PRKCE Tchem Protein kinase C epsilon (1520 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PRKCG Tchem Protein kinase C gamma (2471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PRKCA Tchem Protein kinase C alpha (5923 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PRKCQ Tchem Protein kinase C theta (3319 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
K562 (73714 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Raji (5516 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U2OS (164939 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U-937 (7138 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Jurkat (10389 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HeLa (62764 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RASGRP3 Tchem RAS guanyl releasing protein 3 (130 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLK Tbio DNA polymerase kappa (8653 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RASGRP1 Tchem RAS guanyl-releasing protein 1 (22 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SNU-387 (161 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSPA5 Tchem 78 kDa glucose-regulated protein (3319 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RUNX1 Tbio Runt-related transcription factor 1/Core-binding factor subunit beta (7867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PRKD3 Tchem Protein kinase C (PKC) (1010 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK-293T (167025 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Prkcd Protein kinase C delta (192 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Prkcb Protein kinase C beta (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Aspergillus fumigatus (16427 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human gammaherpesvirus 4 (1538 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human immunodeficiency virus 1 (70413 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Semliki Forest virus (705 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Sindbis virus (1599 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human immunodeficiency virus 2 (5592 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human immunodeficiency virus (3636 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rat1 (211 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vero (26788 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NIH3T3 (5395 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Luciferin 4-monooxygenase (66902 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Chikungunya virus (1339 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name [(1S,2S,6R,10S,11R,13S,14R,15R)-13-acetyloxy-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxo-14-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] tetradecanoate
INCHI InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1
InChi Key PHEDXBVPIONUQT-RGYGYFBISA-N
Canonical SMILES CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C
Isomeric SMILES CCCCCCCCCCCCCC(=O)O[C@@H]1[C@H]([C@]2([C@@H](C=C(C[C@]3([C@H]2C=C(C3=O)C)O)CO)[C@H]4[C@@]1(C4(C)C)OC(=O)C)O)C
WGK Germany 3
RTECS QH4377000
PubChem CID 27924
UN Number 2811
Packing Group I
Molecular Weight 616.83

Certificates

Certificate of Analysis(COA)

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14 results found

Lot NumberCertificate TypeDateItem
J2309310Certificate of AnalysisSep 12, 2023 P167764
J2309311Certificate of AnalysisSep 12, 2023 P167764
J2309312Certificate of AnalysisSep 12, 2023 P167764
J2309415Certificate of AnalysisSep 12, 2023 P167764
A2316127Certificate of AnalysisJan 30, 2023 P167764
I2307046Certificate of AnalysisOct 17, 2022 P167764
K2203493Certificate of AnalysisOct 17, 2022 P167764
K2203498Certificate of AnalysisOct 17, 2022 P167764
K2203501Certificate of AnalysisOct 17, 2022 P167764
K2203502Certificate of AnalysisOct 17, 2022 P167764
I2202648Certificate of AnalysisAug 12, 2022 P167764
I2202649Certificate of AnalysisAug 12, 2022 P167764
I2202650Certificate of AnalysisAug 12, 2022 P167764
I2202653Certificate of AnalysisAug 12, 2022 P167764

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Chemical and Physical Properties

SensitivityLight & air sensitive

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P264:Wash hands [and …] thoroughly after handling.

P362+P364:Take off contaminated clothing and wash it before reuse.

P332+P317:If skin irritation occurs: Get medical help.

WGK Germany 3
RTECS QH4377000
Class 6.1

Related Documents

Citations of This Product

1. Feng Zhu, Zeyu Liu, Xiaoyu Wu, Die Xu, Quanning Li, Xuejiao Chen, Wei Pang, Xuexin Duan, Yanyan Wang.  (2023)  Enhanced on-Chip modification and intracellular hydrogen peroxide detection via gigahertz acoustic streaming microfluidic platform.  ULTRASONICS SONOCHEMISTRY,  100  (1): (106618).  [PMID:37769590]
2. Qingyuan Cheng, Liman Li, Mingxia Yu.  (2023)  Doping Ag2S quantum dots with Pb yields significantly enhanced in vivo fluorescence imaging in the NIR-II window and comparable toxic effects.  NEW JOURNAL OF CHEMISTRY,      [PMID:]
3. Yuan Liang, Qiuyan Jiang, Haoyang Zou, Jingqi Zhao, Jie Zhang, Li Ren.  (2023)  Withaferin A: A potential selective glucocorticoid receptor modulator with anti-inflammatory effect.  FOOD AND CHEMICAL TOXICOLOGY,  179  (113949).  [PMID:37467946]
4. Xia Gao, Guo Yu, Xuehan Liu, Yinlan Xu, Pengbo Zhang, Weidong Wu.  (2023)  Colorimetric detection of ozone in aqueous solution and imaging in living cells using a novel hemicyanine dye.  Analytical Methods,  15  (23): (2868-2875).  [PMID:37272888]
5. Yan Zhao, Xinquan Yu, Xiao Liu, Dailiang Zhang, He Li, Hanlin Zhou, Weiheng Kong, Fengli Qu.  (2023)  ClO– Induced Dual-Excitation Fluorescent Probes Responding to Diverse Testing Modes with Ratio Methodology.  ANALYTICAL CHEMISTRY,  95  (18): (7170–7177).  [PMID:37114482]
6. Weiqiang Lin, Jialin Huang, Shuang Guo, Meijiao Zhao, Xu Chen, Qiuping Shang, Ruoyuan Zhang, Guangfu Liao, Judun Zheng, Yuhui Liao.  (2023)  A tunable fluorescent probe for superoxide anion detection during inflammation caused by Treponema pallidum.  Journal of Materials Chemistry B,  11  (20): (4523-4528).  [PMID:37161601]
7. Junzhao Yuan, Xiaoqian Huang, Yumeng Zhao, Jianhong Gu, Yan Yuan, Zongping Liu, Hui Zou, Jianchun Bian.  (2022)  Rat Hepatocytes Mitigate Cadmium Toxicity by Forming Annular Gap Junctions and Degrading Them via Endosome–Lysosome Pathway.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  23  (24): (15607).  [PMID:36555247]
8. Zhang Silu, Zhang Lijun, Yu Mengjie, Luo Donghui, Chen Shuai, Liu Weifeng, Zhang Yehui, Zhang Lanyue, Zhao Tiantian.  (2022)  Essential oils of Zingiber officinale: Chemical composition, in vivo alleviation effects on TPA induced ear swelling in mice and in vitro bioactivities.  Frontiers in Nutrition,    [PMID:36352904]
9. Tan Bing, Zhang Shasha, Wang Kemeng, Yan Yingli, Chu Zhili, Wang Qiwen, Li Xiang, Zhu Guifen, Fan Jing, Zhao Huimin.  (2022)  Moisture-resistant and green cyclodextrin metal–organic framework nanozyme based on cross-linkage for visible detection of cellular hydrogen peroxide.  MICROCHIMICA ACTA,  189  (8): (1-10).  [PMID:35882703]
10. Yang Sun, Tiancong Liu, Weiliang Bai.  (2022)  MAF bZIP Transcription Factor B (MAFB) Protected Against Ovalbumin-Induced Allergic Rhinitis via the Alleviation of Inflammation by Restoring the T Helper (Th) 1/Th2/Th17 Imbalance and Epithelial Barrier Dysfunction.  Journal of Asthma and Allergy,  15  ( 267–280).  [PMID:35250280]
11. Yue Wang, Cheng Cheng, Ruofei Ma, Zhangrun Xu, Yukihiro Ozaki.  (2022)  In situ SERS monitoring of intracellular H2O2 in single living cells based on label-free bifunctional Fe3O4@Ag nanoparticles.  ANALYST,  147  (9): (1815-1823).  [PMID:35257133]
12. Yunting Zhang, Yuxi Liu, Jianguang Wang, Zongying Jiang, Lin Zhang, Yong Cui, Danyu Zhao, Yanjie Wang.  (2022)  Atractylenolide II inhibits tumor-associated macrophages (TAMs)-induced lung cancer cell metastasis.  IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY,  44  (2): (227-237).  [PMID:35166628]

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39. Qingyuan Cheng, Liman Li, Mingxia Yu.  (2023)  Doping Ag2S quantum dots with Pb yields significantly enhanced in vivo fluorescence imaging in the NIR-II window and comparable toxic effects.  NEW JOURNAL OF CHEMISTRY,      [PMID:]
40. Yuan Liang, Qiuyan Jiang, Haoyang Zou, Jingqi Zhao, Jie Zhang, Li Ren.  (2023)  Withaferin A: A potential selective glucocorticoid receptor modulator with anti-inflammatory effect.  FOOD AND CHEMICAL TOXICOLOGY,  179  (113949).  [PMID:37467946]
41. Xia Gao, Guo Yu, Xuehan Liu, Yinlan Xu, Pengbo Zhang, Weidong Wu.  (2023)  Colorimetric detection of ozone in aqueous solution and imaging in living cells using a novel hemicyanine dye.  Analytical Methods,  15  (23): (2868-2875).  [PMID:37272888]
42. Yan Zhao, Xinquan Yu, Xiao Liu, Dailiang Zhang, He Li, Hanlin Zhou, Weiheng Kong, Fengli Qu.  (2023)  ClO– Induced Dual-Excitation Fluorescent Probes Responding to Diverse Testing Modes with Ratio Methodology.  ANALYTICAL CHEMISTRY,  95  (18): (7170–7177).  [PMID:37114482]
43. Weiqiang Lin, Jialin Huang, Shuang Guo, Meijiao Zhao, Xu Chen, Qiuping Shang, Ruoyuan Zhang, Guangfu Liao, Judun Zheng, Yuhui Liao.  (2023)  A tunable fluorescent probe for superoxide anion detection during inflammation caused by Treponema pallidum.  Journal of Materials Chemistry B,  11  (20): (4523-4528).  [PMID:37161601]
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