Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P167764-1mg | 1mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $58.90 | |
P167764-5mg | 5mg | In stock | $105.90 | |
P167764-10mg | 10mg | In stock | $153.90 | |
P167764-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $276.90 | |
P167764-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $498.90 |
PKC activator
Synonyms | Phorbol 12-myristate 13-acetate | 16561-29-8 | 12-O-Tetradecanoylphorbol-13-acetate | phorbol-12-myristate-13-acetate | 12-O-Tetradecanoylphorbol 13-acetate | Phorbol ester | Tetradecanoylphorbol acetate | Factor A1 | 12-Tetradecanoylphorbol 13-acetate | Phorbol myristate |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Phobos 12 tetradecanoate 13 acetate is an effective tumor promoter that can activate protein kinase C both in vivo and in vitro. This is a type of phorbol ester that is associated with many cellular responses, including gene transcription, cell division a |
Storage Temp | Protected from light,Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ACTIVATOR, GATING INHIBITOR |
Mechanism of action | Gating inhibitor of K ir3.4;Activator of K Na1.1;Gating inhibitor of K Na1.2;Activator of TRPV4 |
Note | This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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IUPAC Name | [(1S,2S,6R,10S,11R,13S,14R,15R)-13-acetyloxy-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxo-14-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] tetradecanoate |
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INCHI | InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1 |
InChi Key | PHEDXBVPIONUQT-RGYGYFBISA-N |
Canonical SMILES | CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C |
Isomeric SMILES | CCCCCCCCCCCCCC(=O)O[C@@H]1[C@H]([C@]2([C@@H](C=C(C[C@]3([C@H]2C=C(C3=O)C)O)CO)[C@H]4[C@@]1(C4(C)C)OC(=O)C)O)C |
WGK Germany | 3 |
RTECS | QH4377000 |
PubChem CID | 27924 |
UN Number | 2811 |
Packing Group | I |
Molecular Weight | 616.83 |
PubChem CID | 27924 |
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ChEMBL Ligand | CHEMBL279115 |
BindingDB Ligand | 50099066 |
Wikipedia | 12-O-Tetradecanoylphorbol-13-acetate |
CAS Registry No. | 16561-29-8 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
J2309310 | Certificate of Analysis | Sep 12, 2023 | P167764 |
J2309311 | Certificate of Analysis | Sep 12, 2023 | P167764 |
J2309312 | Certificate of Analysis | Sep 12, 2023 | P167764 |
J2309415 | Certificate of Analysis | Sep 12, 2023 | P167764 |
A2316127 | Certificate of Analysis | Jan 30, 2023 | P167764 |
I2307046 | Certificate of Analysis | Oct 17, 2022 | P167764 |
K2203493 | Certificate of Analysis | Oct 17, 2022 | P167764 |
K2203498 | Certificate of Analysis | Oct 17, 2022 | P167764 |
K2203501 | Certificate of Analysis | Oct 17, 2022 | P167764 |
K2203502 | Certificate of Analysis | Oct 17, 2022 | P167764 |
I2202648 | Certificate of Analysis | Aug 12, 2022 | P167764 |
I2202649 | Certificate of Analysis | Aug 12, 2022 | P167764 |
I2202650 | Certificate of Analysis | Aug 12, 2022 | P167764 |
I2202653 | Certificate of Analysis | Aug 12, 2022 | P167764 |
Sensitivity | Light & air sensitive |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P264:Wash hands [and …] thoroughly after handling. P362+P364:Take off contaminated clothing and wash it before reuse. P332+P317:If skin irritation occurs: Get medical help. |
WGK Germany | 3 |
RTECS | QH4377000 |
Class | 6.1 |
Starting at $478.90
1. Feng Zhu, Zeyu Liu, Xiaoyu Wu, Die Xu, Quanning Li, Xuejiao Chen, Wei Pang, Xuexin Duan, Yanyan Wang. (2023) Enhanced on-Chip modification and intracellular hydrogen peroxide detection via gigahertz acoustic streaming microfluidic platform. ULTRASONICS SONOCHEMISTRY, 100 (1): (106618). [PMID:37769590] |
2. Qingyuan Cheng, Liman Li, Mingxia Yu. (2023) Doping Ag2S quantum dots with Pb yields significantly enhanced in vivo fluorescence imaging in the NIR-II window and comparable toxic effects. NEW JOURNAL OF CHEMISTRY, [PMID:] |
3. Yuan Liang, Qiuyan Jiang, Haoyang Zou, Jingqi Zhao, Jie Zhang, Li Ren. (2023) Withaferin A: A potential selective glucocorticoid receptor modulator with anti-inflammatory effect. FOOD AND CHEMICAL TOXICOLOGY, 179 (113949). [PMID:37467946] |
4. Xia Gao, Guo Yu, Xuehan Liu, Yinlan Xu, Pengbo Zhang, Weidong Wu. (2023) Colorimetric detection of ozone in aqueous solution and imaging in living cells using a novel hemicyanine dye. Analytical Methods, 15 (23): (2868-2875). [PMID:37272888] |
5. Yan Zhao, Xinquan Yu, Xiao Liu, Dailiang Zhang, He Li, Hanlin Zhou, Weiheng Kong, Fengli Qu. (2023) ClO– Induced Dual-Excitation Fluorescent Probes Responding to Diverse Testing Modes with Ratio Methodology. ANALYTICAL CHEMISTRY, 95 (18): (7170–7177). [PMID:37114482] |
6. Weiqiang Lin, Jialin Huang, Shuang Guo, Meijiao Zhao, Xu Chen, Qiuping Shang, Ruoyuan Zhang, Guangfu Liao, Judun Zheng, Yuhui Liao. (2023) A tunable fluorescent probe for superoxide anion detection during inflammation caused by Treponema pallidum. Journal of Materials Chemistry B, 11 (20): (4523-4528). [PMID:37161601] |
7. Junzhao Yuan, Xiaoqian Huang, Yumeng Zhao, Jianhong Gu, Yan Yuan, Zongping Liu, Hui Zou, Jianchun Bian. (2022) Rat Hepatocytes Mitigate Cadmium Toxicity by Forming Annular Gap Junctions and Degrading Them via Endosome–Lysosome Pathway. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (24): (15607). [PMID:36555247] |
8. Zhang Silu, Zhang Lijun, Yu Mengjie, Luo Donghui, Chen Shuai, Liu Weifeng, Zhang Yehui, Zhang Lanyue, Zhao Tiantian. (2022) Essential oils of Zingiber officinale: Chemical composition, in vivo alleviation effects on TPA induced ear swelling in mice and in vitro bioactivities. Frontiers in Nutrition, 9 [PMID:36352904] |
9. Tan Bing, Zhang Shasha, Wang Kemeng, Yan Yingli, Chu Zhili, Wang Qiwen, Li Xiang, Zhu Guifen, Fan Jing, Zhao Huimin. (2022) Moisture-resistant and green cyclodextrin metal–organic framework nanozyme based on cross-linkage for visible detection of cellular hydrogen peroxide. MICROCHIMICA ACTA, 189 (8): (1-10). [PMID:35882703] |
10. Yang Sun, Tiancong Liu, Weiliang Bai. (2022) MAF bZIP Transcription Factor B (MAFB) Protected Against Ovalbumin-Induced Allergic Rhinitis via the Alleviation of Inflammation by Restoring the T Helper (Th) 1/Th2/Th17 Imbalance and Epithelial Barrier Dysfunction. Journal of Asthma and Allergy, 15 ( 267–280). [PMID:35250280] |
11. Yue Wang, Cheng Cheng, Ruofei Ma, Zhangrun Xu, Yukihiro Ozaki. (2022) In situ SERS monitoring of intracellular H2O2 in single living cells based on label-free bifunctional Fe3O4@Ag nanoparticles. ANALYST, 147 (9): (1815-1823). [PMID:35257133] |
12. Yunting Zhang, Yuxi Liu, Jianguang Wang, Zongying Jiang, Lin Zhang, Yong Cui, Danyu Zhao, Yanjie Wang. (2022) Atractylenolide II inhibits tumor-associated macrophages (TAMs)-induced lung cancer cell metastasis. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 44 (2): (227-237). [PMID:35166628] |
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38. Feng Zhu, Zeyu Liu, Xiaoyu Wu, Die Xu, Quanning Li, Xuejiao Chen, Wei Pang, Xuexin Duan, Yanyan Wang. (2023) Enhanced on-Chip modification and intracellular hydrogen peroxide detection via gigahertz acoustic streaming microfluidic platform. ULTRASONICS SONOCHEMISTRY, 100 (1): (106618). [PMID:37769590] |
39. Qingyuan Cheng, Liman Li, Mingxia Yu. (2023) Doping Ag2S quantum dots with Pb yields significantly enhanced in vivo fluorescence imaging in the NIR-II window and comparable toxic effects. NEW JOURNAL OF CHEMISTRY, [PMID:] |
40. Yuan Liang, Qiuyan Jiang, Haoyang Zou, Jingqi Zhao, Jie Zhang, Li Ren. (2023) Withaferin A: A potential selective glucocorticoid receptor modulator with anti-inflammatory effect. FOOD AND CHEMICAL TOXICOLOGY, 179 (113949). [PMID:37467946] |
41. Xia Gao, Guo Yu, Xuehan Liu, Yinlan Xu, Pengbo Zhang, Weidong Wu. (2023) Colorimetric detection of ozone in aqueous solution and imaging in living cells using a novel hemicyanine dye. Analytical Methods, 15 (23): (2868-2875). [PMID:37272888] |
42. Yan Zhao, Xinquan Yu, Xiao Liu, Dailiang Zhang, He Li, Hanlin Zhou, Weiheng Kong, Fengli Qu. (2023) ClO– Induced Dual-Excitation Fluorescent Probes Responding to Diverse Testing Modes with Ratio Methodology. ANALYTICAL CHEMISTRY, 95 (18): (7170–7177). [PMID:37114482] |
43. Weiqiang Lin, Jialin Huang, Shuang Guo, Meijiao Zhao, Xu Chen, Qiuping Shang, Ruoyuan Zhang, Guangfu Liao, Judun Zheng, Yuhui Liao. (2023) A tunable fluorescent probe for superoxide anion detection during inflammation caused by Treponema pallidum. Journal of Materials Chemistry B, 11 (20): (4523-4528). [PMID:37161601] |
44. Junzhao Yuan, Xiaoqian Huang, Yumeng Zhao, Jianhong Gu, Yan Yuan, Zongping Liu, Hui Zou, Jianchun Bian. (2022) Rat Hepatocytes Mitigate Cadmium Toxicity by Forming Annular Gap Junctions and Degrading Them via Endosome–Lysosome Pathway. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (24): (15607). [PMID:36555247] |
45. Zhang Silu, Zhang Lijun, Yu Mengjie, Luo Donghui, Chen Shuai, Liu Weifeng, Zhang Yehui, Zhang Lanyue, Zhao Tiantian. (2022) Essential oils of Zingiber officinale: Chemical composition, in vivo alleviation effects on TPA induced ear swelling in mice and in vitro bioactivities. Frontiers in Nutrition, 9 [PMID:36352904] |
46. Tan Bing, Zhang Shasha, Wang Kemeng, Yan Yingli, Chu Zhili, Wang Qiwen, Li Xiang, Zhu Guifen, Fan Jing, Zhao Huimin. (2022) Moisture-resistant and green cyclodextrin metal–organic framework nanozyme based on cross-linkage for visible detection of cellular hydrogen peroxide. MICROCHIMICA ACTA, 189 (8): (1-10). [PMID:35882703] |
47. Yang Sun, Tiancong Liu, Weiliang Bai. (2022) MAF bZIP Transcription Factor B (MAFB) Protected Against Ovalbumin-Induced Allergic Rhinitis via the Alleviation of Inflammation by Restoring the T Helper (Th) 1/Th2/Th17 Imbalance and Epithelial Barrier Dysfunction. Journal of Asthma and Allergy, 15 ( 267–280). [PMID:35250280] |
48. Yue Wang, Cheng Cheng, Ruofei Ma, Zhangrun Xu, Yukihiro Ozaki. (2022) In situ SERS monitoring of intracellular H2O2 in single living cells based on label-free bifunctional Fe3O4@Ag nanoparticles. ANALYST, 147 (9): (1815-1823). [PMID:35257133] |
49. Yunting Zhang, Yuxi Liu, Jianguang Wang, Zongying Jiang, Lin Zhang, Yong Cui, Danyu Zhao, Yanjie Wang. (2022) Atractylenolide II inhibits tumor-associated macrophages (TAMs)-induced lung cancer cell metastasis. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 44 (2): (227-237). [PMID:35166628] |