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Phorbol 12-myristate 13-acetate - 98%, high purity , CAS No.16561-29-8, Gating inhibitor of K ir3.4;Activator of K Na1.1;Gating inhibitor of K Na1.2;Activator of TRPV4

  • Moligand™
  • ≥98%
Item Number
P167764
Grouped product items
SKUSizeAvailabilityPrice Qty
P167764-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$58.90
P167764-5mg
5mg
In stock
$105.90
P167764-10mg
10mg
In stock
$153.90
P167764-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$276.90
P167764-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$498.90

PKC activator

Basic Description

SynonymsPhorbol 12-myristate 13-acetate|16561-29-8|12-O-Tetradecanoylphorbol-13-acetate|phorbol-12-myristate-13-acetate|12-O-Tetradecanoylphorbol 13-acetate|Phorbol ester|Tetradecanoylphorbol acetate|Factor A1|12-Tetradecanoylphorbol 13-acetate|Phorbol myristate
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsPotent nanomolar activator of protein kinase C in vivo and in vitro . Binds to C1 domain of protein kinase C, induces membrane translocation and enzyme activation. Also reported to have actions on non-kinase proteins including chimaerins, RasGRP and Unc-1
Storage TempStore at -20°C,Argon charged
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeACTIVATOR, GATING INHIBITOR
Mechanism of actionGating inhibitor of K ir3.4;Activator of K Na1.1;Gating inhibitor of K Na1.2;Activator of TRPV4
NoteThis product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets

RASGRP3 Tchem Ras guanyl-releasing protein 3 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RASGRP1 Tchem RAS guanyl-releasing protein 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RUNX1 Tbio Runt-related transcription factor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RORC Tchem Nuclear receptor ROR-gamma 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TRPV4 Tchem Transient receptor potential cation channel subfamily V member 4 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

POLK Tbio DNA polymerase kappa 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PRKCD Tclin Protein kinase C delta type 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PRKCB Tchem Protein kinase C beta type 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PRKCE Tchem Protein kinase C epsilon type 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HSPA5 Tchem Endoplasmic reticulum chaperone BiP 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ACHE Tclin Acetylcholinesterase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPT Tclin Microtubule-associated protein tau 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BCHE Tclin Cholinesterase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNJ5 Tchem G protein-activated inward rectifier potassium channel 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNT1 Tchem Potassium channel subfamily T member 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNT2 Tchem Potassium channel subfamily T member 2 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PRKCG Tchem Protein kinase C gamma type 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PRKCA Tchem Protein kinase C alpha type 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PRKCQ Tchem Protein kinase C theta type 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name [(1S,2S,6R,10S,11R,13S,14R,15R)-13-acetyloxy-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxo-14-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] tetradecanoate
INCHI InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1
InChi Key PHEDXBVPIONUQT-RGYGYFBISA-N
Canonical SMILES CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C
Isomeric SMILES CCCCCCCCCCCCCC(=O)O[C@@H]1[C@H]([C@]2([C@@H](C=C(C[C@]3([C@H]2C=C(C3=O)C)O)CO)[C@H]4[C@@]1(C4(C)C)OC(=O)C)O)C
WGK Germany 3
RTECS QH4377000
PubChem CID 27924
UN Number 2811
Packing Group I
Molecular Weight 616.83

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

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14 results found

Lot NumberCertificate TypeDateItem
J2309310Certificate of AnalysisSep 12, 2023 P167764
J2309311Certificate of AnalysisSep 12, 2023 P167764
J2309312Certificate of AnalysisSep 12, 2023 P167764
J2309415Certificate of AnalysisSep 12, 2023 P167764
A2316127Certificate of AnalysisJan 30, 2023 P167764
I2307046Certificate of AnalysisOct 17, 2022 P167764
K2203493Certificate of AnalysisOct 17, 2022 P167764
K2203498Certificate of AnalysisOct 17, 2022 P167764
K2203501Certificate of AnalysisOct 17, 2022 P167764
K2203502Certificate of AnalysisOct 17, 2022 P167764
I2202648Certificate of AnalysisAug 12, 2022 P167764
I2202649Certificate of AnalysisAug 12, 2022 P167764
I2202650Certificate of AnalysisAug 12, 2022 P167764
I2202653Certificate of AnalysisAug 12, 2022 P167764

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Chemical and Physical Properties

SensitivityLight & air sensitive

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P264:Wash hands [and …] thoroughly after handling.

P362+P364:Take off contaminated clothing and wash it before reuse.

P332+P317:If skin irritation occurs: Get medical help.

WGK Germany 3
RTECS QH4377000
Class 6.1

Related Documents

References

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