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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P276251-10mg | 10mg | In stock | $118.90 | |
P276251-50mg | 50mg | In stock | $423.90 | |
P276251-100mg | 100mg | In stock | $739.90 |
Selective ERβ antagonist
Synonyms | NN82CVN36N | HB2503 | HMS3677P09 | BS-17633 | 4-(2-Phenyl-5,7-bis-trifluoromethyl-pyrazolo[1,5-a]pyrimidin-3-yl)-phenol | C20H11F6N3O | C76580 | EX-A3507 | HMS2307J06 | DTXSID10458573 | SCHEMBL15556029 | CCG-268920 | Pyrazolo[1,5-a]pyrimidine, 2a | AKOS00 |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Selective ERβ antagonist. Enhances cell growth. Impairs Nrf2 activation. Shows antiestrogenic effects in vivo. |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Antagonist of Estrogen receptor-β |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol |
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INCHI | InChI=1S/C20H11F6N3O/c21-19(22,23)14-10-15(20(24,25)26)29-18(27-14)16(11-6-8-13(30)9-7-11)17(28-29)12-4-2-1-3-5-12/h1-10,30H |
InChi Key | AEZPAUSGTAHLOQ-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C(C=C1)C2=NN3C(=CC(=NC3=C2C4=CC=C(C=C4)O)C(F)(F)F)C(F)(F)F |
Isomeric SMILES | C1=CC=C(C=C1)C2=NN3C(=CC(=NC3=C2C4=CC=C(C=C4)O)C(F)(F)F)C(F)(F)F |
PubChem CID | 11201035 |
UN Number | 2811 |
Packing Group | III |
Molecular Weight | 423.31 |
PubChem CID | 11201035 |
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CAS Registry No. | 805239-56-9 |
ChEMBL Ligand | CHEMBL191066 |
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Solubility | Soluble in ethanol to 100 mM and in DMSO to 100 mM |
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Pictogram(s) | GHS06 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed |
Precautionary Statements | P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P310+P330:IF SWALLOWED: Rinse mouth.Immediately call a POISON CENTER/doctor/. |
Class | 6.1 |
RIDADR | UN28116.1/PGIII |
1. Medwid S et al.. (2018) Bisphenol A stimulates adrenal cortical cell proliferation via ERß-mediated activation of the sonic hedgehog signalling pathway.. J Steroid Biochem Mol Biol, 178 (254-262). [PMID:29307715] |
2. Oo PS et al.. (2018) Estrogen Regulates Mitochondrial Morphology through Phosphorylation of Dynamin-related Protein 1 in MCF7 Human Breast Cancer Cells.. Acta Histochem Cytochem, 51 (21-31). [PMID:29622847] |
3. Guo P et al.. (2022) Estrogen Suppresses Cytokines Release in cc4821 Neisseria meningitidis Infection via TLR4 and ERβ-p38-MAPK Pathway.. Front Microbiol, 13 (834091). [PMID:35422784] |