Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P108001-100mg | 100mg | In stock | $319.90 | |
P108001-250mg | 250mg | In stock | $720.90 | |
P108001-1g | 1g | In stock | $2,592.90 | |
P108001-5g | 5g | In stock | $11,664.90 | |
P108001-25g | 25g | In stock | $52,488.90 |
Inhibits TNF-induced NF-κB activation
Synonyms | 3,3',4,5'-Tetrahydroxy-trans-stilbene | cid_667639 | K00089 | MLS003171221 | piceatannol | SW219501-1 | 1, 4-[2-(3,5-dihydroxyphenyl)ethenyl]-, (E)- | 1,2-Benzenediol, 4-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]- | BDBM50045936 | CCG-100627 | CS-5657 | Q71906 |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Anti-inflammatory, immunomodulatory and antiproliferative agent. Inhibits p56lckand syk protein tyrosine kinases and inhibits TNF-induced NF-κB activation and gene expression. Synthesis results from conversion ofresveratrol by cytochrome P450 1B1. |
Storage Temp | Store at 2-8°C,Protected from light,Argon charged |
Shipped In | Wet ice |
Product Description | λmax 323(MeOH)(Lit.) |
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Pubchem Sid | 488191023 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488191023 |
IUPAC Name | 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol |
INCHI | InChI=1S/C14H12O4/c15-11-5-10(6-12(16)8-11)2-1-9-3-4-13(17)14(18)7-9/h1-8,15-18H/b2-1+ |
InChi Key | CDRPUGZCRXZLFL-OWOJBTEDSA-N |
Canonical SMILES | C1=CC(=C(C=C1C=CC2=CC(=CC(=C2)O)O)O)O |
Isomeric SMILES | C1=CC(=C(C=C1/C=C/C2=CC(=CC(=C2)O)O)O)O |
WGK Germany | 3 |
Alternate CAS | 4339-71-3,10083-24-6 |
PubChem CID | 667639 |
NSC Number | 365798 |
MeSH Entry Terms | 3'-hydroxyresveratol;3,3',4',5-tetrahydroxystilbene;3,3',4,5'-tetrahydroxy stilbene;3,3',4,5'-tetrahydroxystilbene;3,5,3',4'-tetrahydroxy-stilbene;3,5,3',4'-tetrahydroxy-trans-stilbene;3,5,3',4'-tetrahydroxystilbene;astringinin;demethyl isorhapontigenin;p |
Molecular Weight | 244.25 |
Reaxy-Rn | 1879860 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
A2417558 | Certificate of Analysis | Nov 22, 2023 | P108001 |
G2317101 | Certificate of Analysis | Jun 15, 2023 | P108001 |
G2317102 | Certificate of Analysis | Jun 15, 2023 | P108001 |
G2317105 | Certificate of Analysis | Jun 15, 2023 | P108001 |
G2317106 | Certificate of Analysis | Jun 15, 2023 | P108001 |
G2317111 | Certificate of Analysis | Jun 15, 2023 | P108001 |
G2317124 | Certificate of Analysis | Jun 15, 2023 | P108001 |
G2317132 | Certificate of Analysis | Jun 15, 2023 | P108001 |
G2317133 | Certificate of Analysis | Jun 15, 2023 | P108001 |
G2317142 | Certificate of Analysis | Jun 15, 2023 | P108001 |
G2317161 | Certificate of Analysis | Jun 15, 2023 | P108001 |
Solubility | Solvent:ethanol, Max Conc. mg/mL: 24.43, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 24.43, Max Conc. mM: 100 |
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Sensitivity | Light sensitive;Air sensitive;Heat sensitive |
Boil Point(°C) | 108°C/0.04mmHg |
Melt Point(°C) | 235°C(dec.)(lit.) |
WGK Germany | 3 |
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Reaxy-Rn | 1879860 |
1. Jiang Yucong, Shi Yuehong, Hu Dandan, Song Xingju. (2022) The anti-Toxoplasma activity of the plant natural phenolic compound piceatannol. Frontiers in Veterinary Science, 9 [PMID:35982927] |
2. Shengtao Bo, Sui Kiat Chang, Youxia Shan, Yipeng Chen, Hui Liu, Bailin Li, Yueming Jiang, Hong Zhu, Bao Yang. (2022) The bioactivity of prenylated stilbenoids and their structure-activity relationship. FOOD RESEARCH INTERNATIONAL, 157 (111275). [PMID:35761587] |
3. Yugai Jia, Yumeng Miao, Mengfan Yue, Mei Shu, Zhifeng Wei, Yue Dai. (2018) Tetrandrine attenuates the bone erosion in collagen-induced arthritis rats by inhibiting osteoclastogenesis via spleen tyrosine kinase. FASEB JOURNAL, 32 (6): (3398-3410). [PMID:29401630] |
4. Xie Xiaoyun, Han Chaofei, Zeng Weiqi, Chen Chen, Lu Lixia, Liu Queping, Peng Cong, Zhao Shuang, Su Juan, Chen Xiang. (2017) Possible Involvement of F1F0-ATP synthase and Intracellular ATP in Keratinocyte Differentiation in normal skin and skin lesions. Scientific Reports, 7 (42672). [PMID:28209970] |
5. Guanghe Zhao, Ruifen Zhang, Lei Liu, Yuanyuan Deng, Zhencheng Wei, Yan Zhang, Yongxuan Ma, Mingwei Zhang. (2017) Different thermal drying methods affect the phenolic profiles, their bioaccessibility and antioxidant activity in Rhodomyrtus tomentosa (Ait.) Hassk berries. LWT-FOOD SCIENCE AND TECHNOLOGY, 79 (260). [PMID:] |
1. Muramatsu D et al.. (2017) Aureobasidium pullulans produced ß-glucan is effective to enhance Kurosengoku soybean extract induced Thrombospondin-1 expression.. Sci Rep, 7 (2831). [PMID:28588201] |
2. Lu YQ et al.. (2017) NLRP3 inflammasome activation results in liver inflammation and fibrosis in mice infected with Schistosoma japonicum in a Syk-dependent manner.. Sci Rep, 7 (8120). [PMID:28808303] |
3. Chan CN et al.. (2017) Potent Inhibition of HIV-1 Replication in Resting CD4 T Cells by Resveratrol and Pterostilbene.. Antimicrob Agents Chemother, 61 (9): [PMID:28652233] |
4. Prado Acosta M et al.. (2021) S-Layer From Lactobacillus brevis Modulates Antigen-Presenting Cell Functions via the Mincle-Syk-Card9 Axis.. Front Immunol, 12 (602067). [PMID:33732234] |
5. Jiang Yucong, Shi Yuehong, Hu Dandan, Song Xingju. (2022) The anti-Toxoplasma activity of the plant natural phenolic compound piceatannol. Frontiers in Veterinary Science, 9 [PMID:35982927] |
6. Shengtao Bo, Sui Kiat Chang, Youxia Shan, Yipeng Chen, Hui Liu, Bailin Li, Yueming Jiang, Hong Zhu, Bao Yang. (2022) The bioactivity of prenylated stilbenoids and their structure-activity relationship. FOOD RESEARCH INTERNATIONAL, 157 (111275). [PMID:35761587] |
7. Yugai Jia, Yumeng Miao, Mengfan Yue, Mei Shu, Zhifeng Wei, Yue Dai. (2018) Tetrandrine attenuates the bone erosion in collagen-induced arthritis rats by inhibiting osteoclastogenesis via spleen tyrosine kinase. FASEB JOURNAL, 32 (6): (3398-3410). [PMID:29401630] |
8. Xie Xiaoyun, Han Chaofei, Zeng Weiqi, Chen Chen, Lu Lixia, Liu Queping, Peng Cong, Zhao Shuang, Su Juan, Chen Xiang. (2017) Possible Involvement of F1F0-ATP synthase and Intracellular ATP in Keratinocyte Differentiation in normal skin and skin lesions. Scientific Reports, 7 (42672). [PMID:28209970] |
9. Guanghe Zhao, Ruifen Zhang, Lei Liu, Yuanyuan Deng, Zhencheng Wei, Yan Zhang, Yongxuan Ma, Mingwei Zhang. (2017) Different thermal drying methods affect the phenolic profiles, their bioaccessibility and antioxidant activity in Rhodomyrtus tomentosa (Ait.) Hassk berries. LWT-FOOD SCIENCE AND TECHNOLOGY, 79 (260). [PMID:] |