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Piclamilast - ≥99%(HPLC), high purity , CAS No.144035-83-6, Inhibitor of phosphodiesterase 4A
Potent and selective PDE4 inhibitor
Basic Description Synonyms NCGC00371037-01 | Piclamilast | SCHEMBL26573 | A928568 | SR-01000945166-1 | EN300-133366 | Piclamilast [INN] | UNII-WM58D7C3ZT | 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide | Benzamide, 3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl Specifications & Purity Moligand™, ≥99%(HPLC) Biochemical and Physiological Mechanisms Potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC50= 1 nM at PDE4 from human neutrophils). Displays >19,000-fold selectivity over other PDE isoenzymes. Exhibits anti-inflammatory effects in models of allergic inflammation. Also inhibits LTB4 Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of phosphodiesterase 4A
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 3-cyclopentyloxy-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide INCHI InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23) InChi Key RRRUXBQSQLKHEL-UHFFFAOYSA-N Canonical SMILES COC1=C(C=C(C=C1)C(=O)NC2=C(C=NC=C2Cl)Cl)OC3CCCC3 Isomeric SMILES COC1=C(C=C(C=C1)C(=O)NC2=C(C=NC=C2Cl)Cl)OC3CCCC3 PubChem CID 154575 Molecular Weight 381.25
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 38.12, Max Conc. mM: 100
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
References 1. Zhao Y, Zhang HT, O'Donnell JM. (2003) Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram.. J Pharmacol Exp Ther, 305 (2): (565-72). [PMID:12704225 ] [10.1021/op500134e ]
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