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Pico145 , CAS No.P612830, Channel blocker of TRPC4;Channel blocker of TRPC5
Basic Description
| Synonyms | C31;compound 31 |
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| Specifications & Purity | Moligand™ |
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| Grade | Moligand™ |
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| Action Type | CHANNEL BLOCKER |
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| Mechanism of action | Channel blocker of TRPC4;Channel blocker of TRPC5 |
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Associated Targets(Human)
Associated Targets(non-human)
Names and Identifiers
| IUPAC Name | 7-[(4-chlorophenyl)methyl]-1-(3-hydroxypropyl)-3-methyl-8-[3-(trifluoromethoxy)phenoxy]purine-2,6-dione |
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| INCHI | InChI=1S/C23H20ClF3N4O5/c1-29-19-18(20(33)30(22(29)34)10-3-11-32)31(13-14-6-8-15(24)9-7-14)21(28-19)35-16-4-2-5-17(12-16)36-23(25,26)27/h2,4-9,12,32H,3,10-11,13H2,1H3 |
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| InChi Key | PRJHEJGMSOBHTO-UHFFFAOYSA-N |
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| Canonical SMILES | OCCCn1c(=O)c2n(Cc3ccc(cc3)Cl)c(nc2n(c1=O)C)Oc1cccc(c1)OC(F)(F)F |
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| Isomeric SMILES | CN1C2=C(C(=O)N(C1=O)CCCO)N(C(=N2)OC3=CC(=CC=C3)OC(F)(F)F)CC4=CC=C(C=C4)Cl |
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| PubChem CID | 85473438 |
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References
| 1. Rubaiy HN, Ludlow MJ, Henrot M, Gaunt HJ, Miteva K, Cheung SY, Tanahashi Y, Hamzah N, Musialowski KE, Blythe NM et al.. (2017) Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels.. J Biol Chem, 292 (20): (8158-8173). [PMID:28325835] |
| 2. Minard A, Bauer CC, Chuntharpursat-Bon E, Pickles IB, Wright DJ, Ludlow MJ, Burnham MP, Warriner SL, Beech DJ, Muraki K et al.. (2019) Potent, selective, and subunit-dependent activation of TRPC5 channels by a xanthine derivative.. Br J Pharmacol, 176 (20): (3924-3938). [PMID:31277085] |
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