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Picropodophyllotoxin - analytical standard，≥98%, high purity , Insulin-like growth factor I receptor inhibitor, CAS No.477-47-4, Insulin-like growth factor I receptor inhibitor

analytical standard
Moligand™
≥98%

CAS#: 477-47-4
Formula: C₂₂H₂₂O₈
Molecular Weight: 414.41
MDL number: MFCD01742647
PubChem CID: 72435

Item Number

P114058

Grouped product items
SKU	Size	Availability	Price	Qty
P114058-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$187.90
P114058-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$842.90

Selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor

View related series

Insulin-like growth factor I receptor Inhibitor

Basic Description

Synonyms	Picropodophyllin\|Picropodophyllotoxin\|477-47-4\|AXL1717\|Picropodophyllin (PPP)\|IGF-1R Inhibitor, PPP\|AXL-1717\|AXL 1717\|NSC36407\|NSC-36407\|17434-18-3\|Podophyllotoxin picropodophyllin\|(-)PPP\|(5R,5aR,8aS,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetr
Specifications & Purity	analytical standard，≥98%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	analytical standard, Moligand™
Action Type	INHIBITOR
Mechanism of action	Insulin-like growth factor I receptor inhibitor
Product Description	Picropodophyllotoxin is an insulin-like growth factor-I (IGF-I) receptor kinase inhibitor.

Associated Targets

IGF1R Tclin Insulin-like growth factor 1 receptor 1 Activities

Discover Target: IGF1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TOP2A Tclin DNA topoisomerase 2-alpha 1 Activities

Discover Target: TOP2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(5R,5aR,8aS,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one
INCHI	InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19+,20-/m0/s1
InChi Key	YJGVMLPVUAXIQN-HAEOHBJNSA-N
Canonical SMILES	COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O
Isomeric SMILES	COC1=CC(=CC(=C1OC)OC)[C@H]2[C@H]3[C@H](COC3=O)[C@H](C4=CC5=C(C=C24)OCO5)O
WGK Germany	3
RTECS	LV2510000
PubChem CID	72435
UN Number	3462
Molecular Weight	414.41

PubChem CID

CAS Registry No.

ChEMBL Ligand

DrugBank Ligand

Certificates

Certificate of Analysis(COA)

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2 results found

Lot Number	Certificate Type	Date	Item
C2204533	Certificate of Analysis	Dec 19, 2023	P114058
C2204534	Certificate of Analysis	Dec 19, 2023	P114058

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed H312:Harmful in contact with skin
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/...
WGK Germany	3
RTECS	LV2510000

References

1. Linder S, Shoshan MC, Gupta RS. (2007) Picropodophyllotoxin or podophyllotoxin does not induce cell death via insulin-like growth factor-I receptor.. Cancer Res, 67 (6): (2899; author reply 2899-900). [PMID:17363615]
2. Girnita A, Girnita L, del Prete F, Bartolazzi A, Larsson O, Axelson M. (2004) Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth.. Cancer Res, 64 (1): (236-42). [PMID:14729630]
3. Ekman S, Frödin JE, Harmenberg J, Bergman A, Hedlund A, Dahg P, Alvfors C, Ståhl B, Bergström S, Bergqvist M. (2011) Clinical Phase I study with an Insulin-like Growth Factor-1 receptor inhibitor: experiences in patients with squamous non-small cell lung carcinoma.. Acta Oncol, 50 (3): (441-7). [PMID:20698809]
4. Dean M & Rose J. (2018) Activation of the IGF1 receptor stimulates glycogen synthesis by mink uterine epithelial cells.. Mol Reprod Dev, 85 (5): (449-458). [PMID:29573521]

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