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SKU | Size | Availability | Price | Qty |
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P424154-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $241.90 |
Selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor
Synonyms | Picropodophyllin | Picropodophyllotoxin | 477-47-4 | AXL1717 | Picropodophyllin (PPP) | IGF-1R Inhibitor, PPP | AXL-1717 | AXL 1717 | NSC36407 | NSC-36407 | 17434-18-3 | Podophyllotoxin picropodophyllin | (-)PPP | (5R,5aR,8aS,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetr |
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Specifications & Purity | Moligand™, 10mM in DMSO |
Biochemical and Physiological Mechanisms | Picropodophyllotoxin (PPP) is an orally active insulin-like growth factor-1 receptor (IGF-1R) inhibitor. Picropodophyllotoxin exhibits little effect towards IR, FGFR, PDGFR and EGFR, and exerts no effects on microtubules and DNA topoisomerase II. Picropod |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | Picropodophyllotoxin is an insulin-like growth factor-I (IGF-I) receptor kinase inhibitor. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (5R,5aR,8aS,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one |
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INCHI | InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19+,20-/m0/s1 |
InChi Key | YJGVMLPVUAXIQN-HAEOHBJNSA-N |
Canonical SMILES | COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O |
Isomeric SMILES | COC1=CC(=CC(=C1OC)OC)[C@H]2[C@H]3[C@H](COC3=O)[C@H](C4=CC5=C(C=C24)OCO5)O |
WGK Germany | 3 |
RTECS | LV2510000 |
PubChem CID | 72435 |
UN Number | 3462 |
Molecular Weight | 414.41 |
Enter Lot Number to search for COA:
Pictogram(s) | GHS06 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed H312:Harmful in contact with skin |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/... |
WGK Germany | 3 |
RTECS | LV2510000 |