Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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P329435-1mg | 1mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $599.90 | |
P329435-200μg | 200μg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $191.90 |
an antibiotic agent and a member of the Class I inhibitors that acts as an effective inhibitor of Complex I.
Synonyms | BRD-K73581776-001-01-6 | NCGC00180489-01 | Q7191888 | AKOS040746399 | Piericidine A | SCHEMBL18941698 | 2,6,9,11-Tridecatetraen-4-ol, 13-(4-hydroxy-5,6-dimethoxy-3-methyl-2-pyridyl)-3,5,7,11-tetramethyl-, (all-E)-(4R,5R)- | 2-[(2E,5E,7E,11E)-10R-hydroxy-3 |
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Specifications & Purity | ≥95% |
Source | Streptomycessp. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | Piericidin A is an antibiotic and a member of the Class I inhibitors. Piericidin A acts as an effective inhibitor of the bacterial and mitochondrial type I NADH-ubiquinone oxidoreductases (Complex I). As an inhibitor of NADH dehydrogenase, Piericidin A inhibits electron transfer. Research indicates that Piericidin A prevents the translocation of the NADH-induced proton in the NADH-endogenous ubiquinone reductase reaction, and that Piericidin A binds near the NUOD-NUOB interface of Complex I. Piericidin A is also known as AR-054, Shaoguanmycin B, Antibiotic MT 1882-I, SN 198E, and 2-[(2E,5E,7E,9R,10R,11E)-10-Hydroxy-3,7,9,11-tetramethyl-2,5,7,11-tridecatetraen-1-yl]-5,6-dimethoxy-3-methyl-4(1H)-pyridinone. |
pKa | pKa: 5.22 (Predicted), pKa: 10.17 (Predicted) |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 2-[(2E,5E,7E,9R,10R,11E)-10-hydroxy-3,7,9,11-tetramethyltrideca-2,5,7,11-tetraenyl]-5,6-dimethoxy-3-methyl-1H-pyridin-4-one |
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INCHI | InChI=1S/C25H37NO4/c1-9-18(4)22(27)19(5)15-17(3)12-10-11-16(2)13-14-21-20(6)23(28)24(29-7)25(26-21)30-8/h9-10,12-13,15,19,22,27H,11,14H2,1-8H3,(H,26,28)/b12-10+,16-13+,17-15+,18-9+/t19-,22+/m1/s1 |
InChi Key | BBLGCDSLCDDALX-LKGBESRRSA-N |
Canonical SMILES | CC=C(C)C(C(C)C=C(C)C=CCC(=CCC1=C(C(=O)C(=C(N1)OC)OC)C)C)O |
Isomeric SMILES | C/C=C(\C)/[C@@H]([C@H](C)/C=C(\C)/C=C/C/C(=C/CC1=C(C(=O)C(=C(N1)OC)OC)C)/C)O |
WGK Germany | 1 |
RTECS | YD4588000 |
PubChem CID | 6437838 |
Molecular Weight | 415.57 |
Beilstein | 1555726 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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K2323482 | Certificate of Analysis | Nov 10, 2023 | P329435 |
K2323483 | Certificate of Analysis | Nov 10, 2023 | P329435 |
G2201484 | Certificate of Analysis | Jun 05, 2022 | P329435 |
G2201485 | Certificate of Analysis | Jun 05, 2022 | P329435 |
Solubility | Soluble in 100% ethanol, DMF, DMSO, and water (poorly). |
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Refractive Index | n20D1.53 (Predicted) |
Flash Point(°F) | 185 °F |
Flash Point(°C) | 85 °C |
Boil Point(°C) | ~591.7° C at 760 mmHg (Predicted) (tautomer) |
Melt Point(°C) | 220.48° C (Predicted) (tautomer) |
Pictogram(s) | GHS06 |
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Signal | Danger |
Hazard Statements | H300:Fatal if swallowed H310:Fatal in contact with skin H330:Fatal if inhaled |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P262:Do not get in eyes, on skin, or on clothing. P320:Specific treatment is urgent (see ... on this label). P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P316:Get emergency medical help immediately. |
WGK Germany | 1 |
RTECS | YD4588000 |
RIDADR | NA1993/PGIII |
1. Rui Miao, Cong Jiang, Winston Y. Chang, Haiwei Zhang, Jinsu An, Felicia Ho, Pengcheng Chen, Han Zhang, Caroline Junqueira, Dulguun Amgalan, Felix G. Liang, Junbing Zhang, Charles L. Evavold, Iva Hafner-Bratkovič, Zhibin Zhang, Pietro Fontana, Shiyu Xia, Markus Waldeck-Weiermair, Youdong Pan, Thomas Michel, Liron Bar-Peled, Hao Wu, Jonathan C. Kagan, Richard N. Kitsis, Peng Zhang, Xing Liu, Judy Lieberman. (2023) Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis. IMMUNITY, 56 (15): (2523-2541.e8). [PMID:37924812] [10.1016/j.immuni.2023.10.004] |
1. Rui Miao, Cong Jiang, Winston Y. Chang, Haiwei Zhang, Jinsu An, Felicia Ho, Pengcheng Chen, Han Zhang, Caroline Junqueira, Dulguun Amgalan, Felix G. Liang, Junbing Zhang, Charles L. Evavold, Iva Hafner-Bratkovič, Zhibin Zhang, Pietro Fontana, Shiyu Xia, Markus Waldeck-Weiermair, Youdong Pan, Thomas Michel, Liron Bar-Peled, Hao Wu, Jonathan C. Kagan, Richard N. Kitsis, Peng Zhang, Xing Liu, Judy Lieberman. (2023) Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis. IMMUNITY, 56 (15): (2523-2541.e8). [PMID:37924812] [10.1016/j.immuni.2023.10.004] |