Pifithrin-α is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression. It enhances cell survival after genotoxic stress such as UV irradiation and treatment with cytotoxic comp
Storage Temp
Protected from light,Store at -20°C
Shipped In
Ice chest + Ice pads
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. An inhibitor of p53 that reversibly blocks p53 dependent transcriptional activation and apoptosis.
1.Bohan Liu, Jun Nan, Ruixue Jiang, Fangmin Wu, Langrun Song, Zhencheng Ge, Xuesong Ye, Xinhui Zhang, Wei Wang. (2023) Three-dimensional porous aerogel-bead absorbent with high dispersibility of lanthanum active sites to boost phosphorus scavenging. CHEMICAL ENGINEERING JOURNAL, 451 (138509). [PMID:][10.1016/j.cej.2022.138509]
2.Runxiao Zheng, Liming Wang, Xiaqing Wu, Panpan Song, Yanjing Wang, Haiyuan Zhang. (2021) Biotransformation of soluble-insoluble lanthanum species and its induced NLRP3 inflammasome activation and chronic fibrosis. ENVIRONMENTAL POLLUTION, 284 (117438). [PMID:34058500][10.1016/j.envpol.2021.117438]
References
1.Zhan H et al.. (2021) Downregulation of miR-128 Ameliorates Ang II-Induced Cardiac Remodeling via SIRT1/PIK3R1 Multiple Targets.. Oxid Med Cell Longev, 2021 (8889195). [PMID:34646427]
2.Uehara M et al.. (2020) Pharmacological inhibition of ataxia-telangiectasia mutated exacerbates acute kidney injury by activating p53 signaling in mice.. Sci Rep, 10 (4441). [PMID:32157166]
3.Li S et al.. (2017) Synergistic anticancer effect of combined crocetin and cisplatin on KYSE-150 cells via p53/p21 pathway.. Cancer Cell Int, 17 (98). [PMID:29093644]
4.Jia J et al.. (2021) Transcriptional factor FoxM1-activated microRNA-335-3p maintains the self-renewal of neural stem cells by inhibiting p53 signaling pathway via Fmr1.. Stem Cell Res Ther, 12 (169). [PMID:33691791]
5.Bohan Liu, Jun Nan, Ruixue Jiang, Fangmin Wu, Langrun Song, Zhencheng Ge, Xuesong Ye, Xinhui Zhang, Wei Wang. (2023) Three-dimensional porous aerogel-bead absorbent with high dispersibility of lanthanum active sites to boost phosphorus scavenging. CHEMICAL ENGINEERING JOURNAL, 451 (138509). [PMID:][10.1016/j.cej.2022.138509]
6.Runxiao Zheng, Liming Wang, Xiaqing Wu, Panpan Song, Yanjing Wang, Haiyuan Zhang. (2021) Biotransformation of soluble-insoluble lanthanum species and its induced NLRP3 inflammasome activation and chronic fibrosis. ENVIRONMENTAL POLLUTION, 284 (117438). [PMID:34058500][10.1016/j.envpol.2021.117438]
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