Pifithrin-α is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression. It enhances cell survival after genotoxic stress such as UV irradiation and treatment with cytotoxic comp
Storage Temp
Protected from light,Store at -80°C
Shipped In
Ice chest + Ice pads
Product Description
Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. An inhibitor of p53 that reversibly blocks p53 dependent transcriptional activation and apoptosis.
1.Bohan Liu, Jun Nan, Ruixue Jiang, Fangmin Wu, Langrun Song, Zhencheng Ge, Xuesong Ye, Xinhui Zhang, Wei Wang. (2023) Three-dimensional porous aerogel-bead absorbent with high dispersibility of lanthanum active sites to boost phosphorus scavenging. CHEMICAL ENGINEERING JOURNAL, 451 (138509). [PMID:][10.1016/j.cej.2022.138509]
2.Runxiao Zheng, Liming Wang, Xiaqing Wu, Panpan Song, Yanjing Wang, Haiyuan Zhang. (2021) Biotransformation of soluble-insoluble lanthanum species and its induced NLRP3 inflammasome activation and chronic fibrosis. ENVIRONMENTAL POLLUTION, 284 (117438). [PMID:34058500][10.1016/j.envpol.2021.117438]
References
1.Bohan Liu, Jun Nan, Ruixue Jiang, Fangmin Wu, Langrun Song, Zhencheng Ge, Xuesong Ye, Xinhui Zhang, Wei Wang. (2023) Three-dimensional porous aerogel-bead absorbent with high dispersibility of lanthanum active sites to boost phosphorus scavenging. CHEMICAL ENGINEERING JOURNAL, 451 (138509). [PMID:][10.1016/j.cej.2022.138509]
2.Runxiao Zheng, Liming Wang, Xiaqing Wu, Panpan Song, Yanjing Wang, Haiyuan Zhang. (2021) Biotransformation of soluble-insoluble lanthanum species and its induced NLRP3 inflammasome activation and chronic fibrosis. ENVIRONMENTAL POLLUTION, 284 (117438). [PMID:34058500][10.1016/j.envpol.2021.117438]
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