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PIK-75 - 2mM in DMSO, high purity , CAS No.372196-77-5
Selective p110α PI3K inhibitor
Basic Description Synonyms PIK-75 Hydrochloride | 372196-77-5 | PIK-75 HCl | (E)-N'-((6-bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide hydrochloride | 1462995-14-7 | PIK75hydrochloride | 7GH4IC9PLL | PIK-75 (hydrochloride) | N-[(E)-(6-bromoimidazo[1,2-a]pyri Specifications & Purity 2mM in DMSO Biochemical and Physiological Mechanisms PIK-75 Hydrochloride is a hydrochloride salt form of PIK-75, which is a preferential p110α/γ forms of PI3K inhibitor with IC50 of 6, 1300, 76, 510 nM for p110α, p110β, p110γ, p110δ, respectively. PIK-75 is a PI3K p110α s Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description PIK-75 is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM.
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name N-[(E)-(6-bromoimidazo[1,2-a]pyridin-3-yl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide;hydrochloride INCHI InChI=1S/C16H14BrN5O4S.ClH/c1-11-3-5-13(22(23)24)7-15(11)27(25,26)20(2)19-9-14-8-18-16-6-4-12(17)10-21(14)16;/h3-10H,1-2H3;1H/b19-9+; InChi Key VOUDEIAYNKZQKM-MYHMWQFYSA-N Canonical SMILES CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)N=CC2=CN=C3N2C=C(C=C3)Br.Cl Isomeric SMILES CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)/N=C/C2=CN=C3N2C=C(C=C3)Br.Cl PubChem CID 45265864 Molecular Weight 488.74
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