PIK-75 - 2mM in DMSO, high purity , CAS No.372196-77-5

Item Number

P423673

Grouped product items
SKU	Size	Availability	Price	Qty
P423673-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$103.90

Selective p110α PI3K inhibitor

Basic Description

Synonyms	PIK-75 Hydrochloride\|372196-77-5\|PIK-75 HCl\|(E)-N'-((6-bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide hydrochloride\|1462995-14-7\|PIK75hydrochloride\|7GH4IC9PLL\|PIK-75 (hydrochloride)\|N-[(E)-(6-bromoimidazo[1,2-a]pyri
Specifications & Purity	2mM in DMSO
Biochemical and Physiological Mechanisms	PIK-75 Hydrochloride is a hydrochloride salt form of PIK-75, which is a preferential p110α/γ forms of PI3K inhibitor with IC50 of 6, 1300, 76, 510 nM for p110α, p110β, p110γ, p110δ, respectively. PIK-75 is a PI3K p110α s
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	PIK-75 is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM.

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[(E)-(6-bromoimidazo[1,2-a]pyridin-3-yl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide;hydrochloride
INCHI	InChI=1S/C16H14BrN5O4S.ClH/c1-11-3-5-13(22(23)24)7-15(11)27(25,26)20(2)19-9-14-8-18-16-6-4-12(17)10-21(14)16;/h3-10H,1-2H3;1H/b19-9+;
InChi Key	VOUDEIAYNKZQKM-MYHMWQFYSA-N
Canonical SMILES	CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)N=CC2=CN=C3N2C=C(C=C3)Br.Cl
Isomeric SMILES	CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)/N=C/C2=CN=C3N2C=C(C=C3)Br.Cl
PubChem CID	45265864
Molecular Weight	488.74

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Basic Description