Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P344660-50mg | 50mg | In stock | $219.90 | |
P344660-100mg | 100mg | In stock | $350.90 |
Synonyms | KBioSS_001587 | SCHEMBL15146 | (3S-cis)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone | (3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone | Isoptocarpine | PILOCARPINUM [HPUS] | SDCCGMLS-0003164.P005 | 92-1 |
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Specifications & Purity | Moligand™, ≥98% |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Muscarinic acetylcholine receptor M3 agonist |
ALogP | 1.1 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488179958 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179958 |
IUPAC Name | (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one |
INCHI | InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1 |
InChi Key | QCHFTSOMWOSFHM-WPRPVWTQSA-N |
Canonical SMILES | CCC1C(COC1=O)CC2=CN=CN2C |
Isomeric SMILES | CC[C@H]1[C@H](COC1=O)CC2=CN=CN2C |
PubChem CID | 5910 |
UN Number | 2811 |
Packing Group | III |
Molecular Weight | 208.26 |
PubChem CID | 5910 |
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DrugBank Ligand | DB01085 |
ChEBI | CHEBI:8207 |
CAS Registry No. | 92-13-7 |
Wikipedia | Pilocarpine |
ChEMBL Ligand | CHEMBL550 |
BindingDB Ligand | 50008072 |
RCSB PDB Ligand | 9PL |
PEP | pilocarpine |
DrugCentral Ligand | 2166 |
GPCRdb Ligand | pilocarpine |
PubChem SID | 488179958 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H2420466 | Certificate of Analysis | Aug 02, 2024 | P344660 |
H2420468 | Certificate of Analysis | Aug 02, 2024 | P344660 |
K2321360 | Certificate of Analysis | Nov 09, 2023 | P344660 |
K2321362 | Certificate of Analysis | Nov 09, 2023 | P344660 |
E2320476 | Certificate of Analysis | Apr 13, 2023 | P344660 |
E2320477 | Certificate of Analysis | Apr 13, 2023 | P344660 |
E2320503 | Certificate of Analysis | Apr 13, 2023 | P344660 |
E2320520 | Certificate of Analysis | Apr 13, 2023 | P344660 |
I2226315 | Certificate of Analysis | Sep 15, 2022 | P344660 |
I2226316 | Certificate of Analysis | Sep 15, 2022 | P344660 |
Solubility | Chloroform (Sparingly, Sonicated), Methanol (Slightly) |
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Pictogram(s) | GHS06 |
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Signal | Danger |
Hazard Statements | H300:Fatal if swallowed H330:Fatal if inhaled |
Precautionary Statements | P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P320:Specific treatment is urgent (see ... on this label). P301+P316:IF SWALLOWED: Get emergency medical help immediately. P316:Get emergency medical help immediately. |
Class | 6.1 |
Starting at $47.90
Starting at $345.90
Starting at $12.90
1. Wang Qi, Shi Xulai, Li Ping-Ping, Gao Li, Zhou Yueyuan, Li Luyao, Ye Hao, Fu Xiaoqin, Li Peijun. (2023) microRNA profilings identify plasma biomarkers and targets associated with pediatric epilepsy patients. PEDIATRIC RESEARCH, (16): (1-13). [PMID:37884644] [10.1038/s41390-023-02864-z] |
2. Yusheng Zhang, Xiaoyang Wu, Jie Ding, Borui Su, Zhihong Chen, Zhanwen Xiao, Chengheng Wu, Dan Wei, Jing Sun, Fang Luo, Huabing Yin, Hongsong Fan. (2023) Wireless-Powering Deep Brain Stimulation Platform Based on 1D-Structured Magnetoelectric Nanochains Applied in Antiepilepsy Treatment. ACS Nano, 17 (16): (15796–15809). [PMID:37530448] [10.1021/acsnano.3c03661] |
3. Xue Zhao, Xiaoying Fu, Xinyi Yuan, Aerduosi Shayiranbieke, Ru Xu, Fang Cao, Jianping Ren, Qi Liang, Xinfeng Zhao. (2021) Development and characterization of a selective chromatographic approach to the rapid discovery of ligands binding to muscarinic-3 acetylcholine receptor. JOURNAL OF CHROMATOGRAPHY A, 1653 (462443). [PMID:34365202] [10.1016/j.chroma.2021.462443] |
4. Ziming Zheng, Yu Zhang, Yuxuan Liu, Jinglin Wang, Zheng Cui, Xianglin Pan, Yan Liu, Wenqi Tang, Kaiping Wang. (2021) Metabolic degradation of lentinan in liver mediated by CYP450 enzymes and epoxide hydrolase. CARBOHYDRATE POLYMERS, 253 (117255). [PMID:33279005] [10.1016/j.carbpol.2020.117255] |
5. Di Wang, Meilan Zhou, Yan Wang, Shiren Sun. (2020) Suppression of high-mobility group box 1 ameliorates xerostomia in a Sjögren syndrome-triggered mouse model. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 98 (6): [PMID:31935120] [10.1139/cjpp-2019-0337] |
6. Nan Miao, Yuanbo Zhan, Yingying Xu, Haoze Yuan, Chunlin Qin, Feng Lin, Xiaohua Xie, Sen Mu, Mengtong Yuan, Haibin Mu, Shouli Guo, Ying Li, Bin Zhang. (2019) Loss of Fam20c causes defects in the acinar and duct structure of salivary glands in mice. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 43 (5): (2103-2117). [PMID:30864688] [10.3892/ijmm.2019.4126] |
1. Wang Qi, Shi Xulai, Li Ping-Ping, Gao Li, Zhou Yueyuan, Li Luyao, Ye Hao, Fu Xiaoqin, Li Peijun. (2023) microRNA profilings identify plasma biomarkers and targets associated with pediatric epilepsy patients. PEDIATRIC RESEARCH, (16): (1-13). [PMID:37884644] [10.1038/s41390-023-02864-z] |
2. Yusheng Zhang, Xiaoyang Wu, Jie Ding, Borui Su, Zhihong Chen, Zhanwen Xiao, Chengheng Wu, Dan Wei, Jing Sun, Fang Luo, Huabing Yin, Hongsong Fan. (2023) Wireless-Powering Deep Brain Stimulation Platform Based on 1D-Structured Magnetoelectric Nanochains Applied in Antiepilepsy Treatment. ACS Nano, 17 (16): (15796–15809). [PMID:37530448] [10.1021/acsnano.3c03661] |
3. Xue Zhao, Xiaoying Fu, Xinyi Yuan, Aerduosi Shayiranbieke, Ru Xu, Fang Cao, Jianping Ren, Qi Liang, Xinfeng Zhao. (2021) Development and characterization of a selective chromatographic approach to the rapid discovery of ligands binding to muscarinic-3 acetylcholine receptor. JOURNAL OF CHROMATOGRAPHY A, 1653 (462443). [PMID:34365202] [10.1016/j.chroma.2021.462443] |
4. Ziming Zheng, Yu Zhang, Yuxuan Liu, Jinglin Wang, Zheng Cui, Xianglin Pan, Yan Liu, Wenqi Tang, Kaiping Wang. (2021) Metabolic degradation of lentinan in liver mediated by CYP450 enzymes and epoxide hydrolase. CARBOHYDRATE POLYMERS, 253 (117255). [PMID:33279005] [10.1016/j.carbpol.2020.117255] |
5. Di Wang, Meilan Zhou, Yan Wang, Shiren Sun. (2020) Suppression of high-mobility group box 1 ameliorates xerostomia in a Sjögren syndrome-triggered mouse model. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 98 (6): [PMID:31935120] [10.1139/cjpp-2019-0337] |
6. Nan Miao, Yuanbo Zhan, Yingying Xu, Haoze Yuan, Chunlin Qin, Feng Lin, Xiaohua Xie, Sen Mu, Mengtong Yuan, Haibin Mu, Shouli Guo, Ying Li, Bin Zhang. (2019) Loss of Fam20c causes defects in the acinar and duct structure of salivary glands in mice. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 43 (5): (2103-2117). [PMID:30864688] [10.3892/ijmm.2019.4126] |