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Pilocarpine HCl - ≥99%, high purity , Muscarinic acetylcholine receptor M3 agonist, CAS No.54-71-7, Muscarinic acetylcholine receptor M3 agonist

2 Citations

≥99%

CAS#: 54-71-7
Formula: C₁₁H₁₆N₂O₂·HCl
Molecular Weight: 244.72
Beilstein Registry Number: 4034491
EC Number: 200-212-5
MDL number: MFCD00012722
PubChem CID: 5909
PubChem SID: 488179957

Item Number

P129614

Grouped product items
SKU	Size	Availability	Price
P129614-50mg	50mg	In stock	$12.90
P129614-250mg	250mg	In stock	$52.90
P129614-1g	1g	In stock	$169.90
P129614-5g	5g	In stock	$499.90

Non-selective muscarinic receptor agonist

View related series

GPCR/G Protein mAChR Neuronal Signaling

Basic Description

Synonyms	Mistura P \| SCHEMBL41427 \| MLS001076314 \| AC-33119 \| NCGC00094254-01 \| PILOCARPINE HYDROCHLORIDE [WHO-IP] \| Isoptocarpine \| Isopto-carpine \| PILOCARPINE HYDROCHLORIDE [MI] \| Pilocarpine Hydrochloride Ophthalmic Solution \| VUITY \| PILO \| component of Piloc
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Pilocarpine is a parasympathomimetic alkaloid obtained from the leaves of tropical American shrubs from the genus Pilocarpus. It is a non-selective muscarinic receptor agonist in the parasympathetic nervous system, which acts therapeutically at themuscari
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Action Type	AGONIST
Mechanism of action	Muscarinic acetylcholine receptor M3 agonist
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Pilocarpine HCl is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.

Associated Targets(Human)

ACHE Tclin Acetylcholinesterase (18204 Activities)

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A498 (42825 Activities)

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ACHN (49357 Activities)

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CAKI-1 (44928 Activities)

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CCRF-CEM (65223 Activities)

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COLO 205 (50209 Activities)

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DU-145 (51482 Activities)

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HL-60 (67320 Activities)

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HT-29 (80576 Activities)

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K562 (73714 Activities)

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KM12 (47707 Activities)

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M14 (47487 Activities)

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MCF7 (126967 Activities)

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MOLT-4 (49676 Activities)

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OVCAR-3 (48710 Activities)

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OVCAR-4 (44535 Activities)

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OVCAR-5 (45555 Activities)

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OVCAR-8 (47708 Activities)

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PC-3 (62116 Activities)

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RPMI-8226 (44974 Activities)

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RXF 393 (41971 Activities)

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SF-295 (48000 Activities)

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SK-MEL-2 (46422 Activities)

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SK-MEL-28 (48833 Activities)

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SK-MEL-5 (47095 Activities)

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SK-OV-3 (52876 Activities)

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SN12C (47755 Activities)

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SNB-19 (46794 Activities)

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TK-10 (45540 Activities)

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U-251 (51189 Activities)

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UACC-257 (46019 Activities)

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UACC-62 (47335 Activities)

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UO-31 (46270 Activities)

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786-0 (47912 Activities)

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A549 (127892 Activities)

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NCI/ADR-RES (33767 Activities)

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T47D (39041 Activities)

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EKVX (44102 Activities)

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NCI-H322M (45589 Activities)

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HCC 2998 (41480 Activities)

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HCT-116 (91556 Activities)

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HEK293 (82097 Activities)

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HOP-92 (41141 Activities)

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Hs-578T (29457 Activities)

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NCI-H460 (60772 Activities)

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SF-268 (49410 Activities)

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IGROV-1 (47897 Activities)

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LOX IMVI (44321 Activities)

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HOP-62 (47048 Activities)

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MDA-MB-435 (38290 Activities)

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Associated Targets(non-human)

Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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BCHE Cholinesterase (8742 Activities)

Discover Target: BCHE

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Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

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nfo Endonuclease 4 (425 Activities)

Discover Target: nfo

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488179957
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488179957
IUPAC Name	(3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one;hydrochloride
INCHI	InChI=1S/C11H16N2O2.ClH/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;/h5,7-8,10H,3-4,6H2,1-2H3;1H/t8-,10-;/m0./s1
InChi Key	RNAICSBVACLLGM-GNAZCLTHSA-N
Canonical SMILES	CCC1C(COC1=O)CC2=CN=CN2C.Cl
Isomeric SMILES	CC[C@H]1[C@H](COC1=O)CC2=CN=CN2C.Cl
WGK Germany	3
PubChem CID	5909
Molecular Weight	244.72
Beilstein	4034491

Certificates

Certificate of Analysis(COA)

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29 results found

Lot Number	Certificate Type	Date	Item
L2228058	Certificate of Analysis	Oct 16, 2024	P129614
L2228054	Certificate of Analysis	Oct 16, 2024	P129614
L2228050	Certificate of Analysis	Oct 16, 2024	P129614
J2429599	Certificate of Analysis	Sep 19, 2024	P129614
J2429598	Certificate of Analysis	Sep 19, 2024	P129614
J2429597	Certificate of Analysis	Sep 19, 2024	P129614
J2210639	Certificate of Analysis	Aug 14, 2024	P129614
G2206375	Certificate of Analysis	Apr 07, 2024	P129614
C2414706	Certificate of Analysis	Mar 06, 2024	P129614
C2414705	Certificate of Analysis	Mar 06, 2024	P129614
L2321461	Certificate of Analysis	Dec 13, 2023	P129614
I23211017	Certificate of Analysis	Aug 18, 2023	P129614
I23211018	Certificate of Analysis	Aug 18, 2023	P129614
I23211019	Certificate of Analysis	Aug 18, 2023	P129614
I23211020	Certificate of Analysis	Aug 18, 2023	P129614
F23171039	Certificate of Analysis	Jun 07, 2023	P129614
F23171079	Certificate of Analysis	Jun 07, 2023	P129614
F23171082	Certificate of Analysis	Jun 07, 2023	P129614
F23171117	Certificate of Analysis	Jun 07, 2023	P129614
F23171127	Certificate of Analysis	Jun 07, 2023	P129614
D2129158	Certificate of Analysis	Feb 09, 2023	P129614
L2228051	Certificate of Analysis	Dec 15, 2022	P129614
L2228055	Certificate of Analysis	Dec 15, 2022	P129614
J2210656	Certificate of Analysis	Sep 07, 2022	P129614
J2210655	Certificate of Analysis	Sep 07, 2022	P129614
J2210638	Certificate of Analysis	Sep 07, 2022	P129614
G2206373	Certificate of Analysis	Jun 23, 2022	P129614
G2206374	Certificate of Analysis	Jun 23, 2022	P129614
G2206377	Certificate of Analysis	Jun 23, 2022	P129614

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Chemical and Physical Properties

Solubility	DMSO 49 mg/mL Water 49 mg/mL Ethanol 49 mg/mL
Melt Point(°C)	202-205℃

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H300:Fatal if swallowed H330:Fatal if inhaled
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P320:Specific treatment is urgent (see ... on this label). P301+P316:IF SWALLOWED: Get emergency medical help immediately. P316:Get emergency medical help immediately.
WGK Germany	3

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Citations of This Product

How to Cite Aladdin Scientific Products?

1. Nan Miao, Yuanbo Zhan, Yingying Xu, Haoze Yuan, Chunlin Qin, Feng Lin, Xiaohua Xie, Sen Mu, Mengtong Yuan, Haibin Mu, Shouli Guo, Ying Li, Bin Zhang. (2019) Loss of Fam20c causes defects in the acinar and duct structure of salivary glands in mice. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 43 (5): (2103-2117). [PMID:30864688] [10.3892/ijmm.2019.4126]
2. Zhang Jinghui, Qiao Nana, Ding Xiufang, Wang Jiwen. (2018) Disruption of the GluA2/GAPDH complex using TAT-GluA2NT1-3-2 peptide protects against AMPAR-mediated excitotoxicity after epilepsy. NEUROREPORT, 29 (5): (432). [PMID:29489588] [10.1097/WNR.0000000000000996]

References

1. Zhao J et al.. (2022) Activated astrocytes attenuate neocortical seizures in rodent models through driving Na+-K+-ATPase.. Nat Commun, 13 (7136). [PMID:36414629]
2. Xu K & Stringer JL. (2008) Antioxidants and free radical scavengers do not consistently delay seizure onset in animal models of acute seizures.. Epilepsy Behav, 13 (77-82). [PMID:18396108]
3. Nan Miao, Yuanbo Zhan, Yingying Xu, Haoze Yuan, Chunlin Qin, Feng Lin, Xiaohua Xie, Sen Mu, Mengtong Yuan, Haibin Mu, Shouli Guo, Ying Li, Bin Zhang. (2019) Loss of Fam20c causes defects in the acinar and duct structure of salivary glands in mice. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 43 (5): (2103-2117). [PMID:30864688] [10.3892/ijmm.2019.4126]
4. Zhang Jinghui, Qiao Nana, Ding Xiufang, Wang Jiwen. (2018) Disruption of the GluA2/GAPDH complex using TAT-GluA2NT1-3-2 peptide protects against AMPAR-mediated excitotoxicity after epilepsy. NEUROREPORT, 29 (5): (432). [PMID:29489588] [10.1097/WNR.0000000000000996]

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Pilocarpine HCl - ≥99%, high purity , Muscarinic acetylcholine receptor M3 agonist, CAS No.54-71-7, Muscarinic acetylcholine receptor M3 agonist

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Show more⌵

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Alternative Products

FAQs and Articles

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator