Pilocarpine is a parasympathomimetic alkaloid obtained from the leaves of tropical American shrubs from the genus Pilocarpus. It is a non-selective muscarinic receptor agonist in the parasympathetic nervous system, which acts therapeutically at themuscari
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Action Type
AGONIST
Mechanism of action
Muscarinic acetylcholine receptor M3 agonist
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Pilocarpine HCl is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.
Associated Targets
PMP22Tbio Peripheral myelin protein 22 0 Activities
1.Zhao J et al.. (2022) Activated astrocytes attenuate neocortical seizures in rodent models through driving Na+-K+-ATPase.. Nat Commun, 13 (7136). [PMID:36414629]
2.Xu K & Stringer JL. (2008) Antioxidants and free radical scavengers do not consistently delay seizure onset in animal models of acute seizures.. Epilepsy Behav, 13 (77-82). [PMID:18396108]
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J2210639