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P424663-1ml

1ml

Available within 4-8 weeks(?)

$47.90

Basic Description

Synonyms	Pilocarpine hydrochloride \| 54-71-7 \| (+)-Pilocarpine hydrochloride \| Pilocarpine HCl \| Almocarpine \| Pilocarpal \| Salagen \| Pilocar SMP \| Adsorbocarpine \| Pilomiotin \| Pilocar \| Pilocel \| Pilovisc \| Epicar \| Pilocarpine monohydrochloride \| Sno pilo \| Mistura P \| Pilocarpine muriate \| Isopt
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Pilocarpine is a parasympathomimetic alkaloid obtained from the leaves of tropical American shrubs from the genus Pilocarpus. It is a non-selective muscarinic receptor agonist in the parasympathetic nervous system, which acts therapeutically at themuscari
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Pilocarpine HCl is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.

Associated Targets(Human)

ACHE Tclin Acetylcholinesterase (18204 Activities)

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A498 (42825 Activities)

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ACHN (49357 Activities)

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CAKI-1 (44928 Activities)

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CCRF-CEM (65223 Activities)

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COLO 205 (50209 Activities)

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DU-145 (51482 Activities)

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HL-60 (67320 Activities)

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HT-29 (80576 Activities)

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K562 (73714 Activities)

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KM12 (47707 Activities)

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M14 (47487 Activities)

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MCF7 (126967 Activities)

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MOLT-4 (49676 Activities)

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OVCAR-3 (48710 Activities)

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OVCAR-4 (44535 Activities)

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OVCAR-5 (45555 Activities)

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OVCAR-8 (47708 Activities)

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PC-3 (62116 Activities)

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RPMI-8226 (44974 Activities)

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RXF 393 (41971 Activities)

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SF-295 (48000 Activities)

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SK-MEL-2 (46422 Activities)

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SK-MEL-28 (48833 Activities)

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SK-MEL-5 (47095 Activities)

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SK-OV-3 (52876 Activities)

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SN12C (47755 Activities)

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SNB-19 (46794 Activities)

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TK-10 (45540 Activities)

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U-251 (51189 Activities)

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UACC-257 (46019 Activities)

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UACC-62 (47335 Activities)

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UO-31 (46270 Activities)

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786-0 (47912 Activities)

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A549 (127892 Activities)

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NCI/ADR-RES (33767 Activities)

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T47D (39041 Activities)

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EKVX (44102 Activities)

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NCI-H322M (45589 Activities)

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HCC 2998 (41480 Activities)

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HCT-116 (91556 Activities)

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HEK293 (82097 Activities)

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HOP-92 (41141 Activities)

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Hs-578T (29457 Activities)

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NCI-H460 (60772 Activities)

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SF-268 (49410 Activities)

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IGROV-1 (47897 Activities)

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LOX IMVI (44321 Activities)

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HOP-62 (47048 Activities)

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MDA-MB-435 (38290 Activities)

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Associated Targets(non-human)

Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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BCHE Cholinesterase (8742 Activities)

Discover Target: BCHE

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Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

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nfo Endonuclease 4 (425 Activities)

Discover Target: nfo

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one;hydrochloride
INCHI	InChI=1S/C11H16N2O2.ClH/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;/h5,7-8,10H,3-4,6H2,1-2H3;1H/t8-,10-;/m0./s1
InChi Key	RNAICSBVACLLGM-GNAZCLTHSA-N
Canonical SMILES	CCC1C(COC1=O)CC2=CN=CN2C.Cl
Isomeric SMILES	CC[C@H]1[C@H](COC1=O)CC2=CN=CN2C.Cl
WGK Germany	3
PubChem CID	5909
Molecular Weight	244.72
Beilstein	4034491

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Melt Point(°C)	202-205℃

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H300:Fatal if swallowed H330:Fatal if inhaled
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P320:Specific treatment is urgent (see ... on this label). P301+P316:IF SWALLOWED: Get emergency medical help immediately. P316:Get emergency medical help immediately.
WGK Germany	3

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Nan Miao, Yuanbo Zhan, Yingying Xu, Haoze Yuan, Chunlin Qin, Feng Lin, Xiaohua Xie, Sen Mu, Mengtong Yuan, Haibin Mu, Shouli Guo, Ying Li, Bin Zhang. (2019) Loss of Fam20c causes defects in the acinar and duct structure of salivary glands in mice. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 43 (5): (2103-2117). [PMID:30864688] [10.3892/ijmm.2019.4126]
2. Zhang Jinghui, Qiao Nana, Ding Xiufang, Wang Jiwen. (2018) Disruption of the GluA2/GAPDH complex using TAT-GluA2NT1-3-2 peptide protects against AMPAR-mediated excitotoxicity after epilepsy. NEUROREPORT, 29 (5): (432). [PMID:29489588] [10.1097/WNR.0000000000000996]

References

1. Nan Miao, Yuanbo Zhan, Yingying Xu, Haoze Yuan, Chunlin Qin, Feng Lin, Xiaohua Xie, Sen Mu, Mengtong Yuan, Haibin Mu, Shouli Guo, Ying Li, Bin Zhang. (2019) Loss of Fam20c causes defects in the acinar and duct structure of salivary glands in mice. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 43 (5): (2103-2117). [PMID:30864688] [10.3892/ijmm.2019.4126]
2. Zhang Jinghui, Qiao Nana, Ding Xiufang, Wang Jiwen. (2018) Disruption of the GluA2/GAPDH complex using TAT-GluA2NT1-3-2 peptide protects against AMPAR-mediated excitotoxicity after epilepsy. NEUROREPORT, 29 (5): (432). [PMID:29489588] [10.1097/WNR.0000000000000996]

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Pilocarpine HCl - 10mM in DMSO, high purity , CAS No.54-71-7

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

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