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Pioglitazone - ≥98%, high purity , CAS No.111025-46-8, Agonist of Peroxisome proliferator-activated receptor-γ;Channel blocker of TRPM3

1 Citations
Item Number
P129907
Grouped product items
SKUSizeAvailabilityPrice Qty
P129907-10mg
10mg
In stock
$91.90
P129907-50mg
50mg
In stock
$129.90
P129907-250mg
250mg
In stock
$585.90
P129907-1g
1g
In stock
$2,106.90
P129907-5g
5g
In stock
$9,477.90
P129907-25g
25g
In stock
$42,646.90
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Selective PPARγ agonist

View related series
Peroxisome proliferator-activated receptor-γ Agonist TRPM3 Channel blocker

Basic Description

SynonymsHMS2089H14 | HY-13956 | KBio2_004671 | PIOGLITAZONE [VANDF] | DTXCID1017129 | 5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione | PIOGLITAZONE [WHO-DD] | SB17323 | SBI-0206791.P001 | 2,4-Thiazolidinedione, 5-((4-(2-(5-ethyl-2-pyrid
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsPioglitazone, a thaizolidinedione derivative, has been shown to be a high affinity ligand for the peroxisome proliferator-activated receptor (PPAR), specifically PPARγ1 and PPARα activator. Binding assays have indicated that this activation is due to dire
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST, CHANNEL BLOCKER
Mechanism of actionAgonist of Peroxisome proliferator-activated receptor-γ;Channel blocker of TRPM3
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Pioglitazone (Actos) is a selective peroxisome proliferator-activated receptor gamma stimulator.
A PPAR agonist with potential antidiabetic characteristics.

Associated Targets(Human)

TRPM3 Tchem Transient receptor potential cation channel subfamily M member 3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CA2 Tclin Carbonic anhydrase 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ABCB11 Tchem Bile salt export pump (6 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MAOB Tclin Amine oxidase [flavin-containing] B (4 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CISD1 Tchem CDGSH iron-sulfur domain-containing protein 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PPARG Tclin Peroxisome proliferator-activated receptor gamma (6 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488179857
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488179857
IUPAC Name 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
INCHI InChI=1S/C19H20N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23)
InChi Key HYAFETHFCAUJAY-UHFFFAOYSA-N
Canonical SMILES CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
Isomeric SMILES CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
Alternate CAS 112529-15-4
PubChem CID 4829
Molecular Weight 356.44

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot NumberCertificate TypeDateItem
C2401029Certificate of AnalysisJun 03, 2023 P129907
F23271048Certificate of AnalysisJun 03, 2023 P129907
F2327706Certificate of AnalysisJun 03, 2023 P129907
F2327707Certificate of AnalysisJun 03, 2023 P129907
F2327710Certificate of AnalysisJun 03, 2023 P129907
F2327801Certificate of AnalysisJun 03, 2023 P129907
F2327808Certificate of AnalysisJun 03, 2023 P129907
F2327817Certificate of AnalysisJun 03, 2023 P129907
F2327819Certificate of AnalysisJun 03, 2023 P129907
F2327820Certificate of AnalysisJun 03, 2023 P129907
F2327852Certificate of AnalysisJun 03, 2023 P129907
D1513136Certificate of AnalysisNov 16, 2022 P129907

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Chemical and Physical Properties

SolubilitySoluble in water (<1 mg/ml at 25 °C), DMSO (15 mg/ml at 25 °C), DMF (2.5 mg/ml), ethanol (<1 mg/ml at 25 °C), and 1:1 solution of DMSO:PBS (pH 7.2) (~ 0.1 mg/ml).

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

H312:Harmful in contact with skin

H332:Harmful if inhaled

H302+H312+H332:Harmful if swallowed, in contact with skin or if inhaled

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P317:Get emergency medical help.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

Related Documents

 SDS

 Specification Sheet

Citations of This Product

1. Jiawen Ai, Weize Zhao, Quan Yu, Xiang Qian, Jianhua Zhou, Xinming Huo, Fei Tang.  (2023)  SR-Unet: A Super-Resolution Algorithm for Ion Trap Mass Spectrometers Based on the Deep Neural Network.  ANALYTICAL CHEMISTRY,  95  (47): (17407–17415).  [PMID:37963290]

References

1. Morató L, Galino J, Ruiz M, Calingasan NY, Starkov AA, Dumont M, Naudí A, Martínez JJ, Aubourg P, Portero-Otín M et al..  (2013)  Pioglitazone halts axonal degeneration in a mouse model of X-linked adrenoleukodystrophy..  Brain,  136  (Pt 8): (2432-43).  [PMID:23794606]
2. Jiawen Ai, Weize Zhao, Quan Yu, Xiang Qian, Jianhua Zhou, Xinming Huo, Fei Tang.  (2023)  SR-Unet: A Super-Resolution Algorithm for Ion Trap Mass Spectrometers Based on the Deep Neural Network.  ANALYTICAL CHEMISTRY,  95  (47): (17407–17415).  [PMID:37963290]

Solution Calculators

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