Pirfenidone - ≥98%(GC), high purity , CAS No.53179-13-8

Item Number

P129335

• Synonyms: PIRFENIDONE|53179-13-8|5-methyl-1-phenylpyridin-2(1H)-one|Esbriet|Deskar|Pirespa|AMR-69|5-Methyl-1-phenyl-2-(1H)-pyridone|Pirfenidona|Pirfenidonum|2(1H)-Pyridinone, 5-methyl-1-phenyl-|AMR 69|5-Methyl-1-phenyl-2(1H)-pyridone|5-methyl-1-phenyl-2(1H)-pyridin
• Specifications & Purity: Moligand™, ≥98%(GC)
• Biochemical and Physiological Mechanisms: Pirfenidone inhibits collagen production and fibroblast proliferation. It has shown antifibrotic and anti-inflammatory properties in variety of animal models of pulmonary fibrosis, and in clinical trials.Orally active anti-inflammatory, antifibrotic and a
• Shipped In: Normal
• Grade: Moligand™
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Application：

Pyrfenidone is used for:
1、 As a postoperative eye drop for rabbits, analyze its anti fibrotic effect and improve glaucoma filtration surgery.
2、As an anti scarring agent, check if it affects the foreign body reaction after implantation of glaucoma drainage device (GDD) in rabbits.
3、Test its anti fibrotic potential in primary culture of human orbital fibroblasts (hOF).
4、 As tumor necrosis factor (TNF) α） Inhibitors, studying their role in hypoxia.

Explanation：

Pyrfenidone (5-methyl-1-phenyl-2- [1H] - pyridone) is a synthesized pyridine derivative.