Piribedil dihydrochloride is a salt form of Piribedil. Piribedil is a dopamine agonist reported to have selectivity for D3DR (D3 subtype receptors) with moderate to non-significant affinity for D2 and D1 receptors. As an atypical dopamine agonist reported to dose-dependently increase locomotor activity in rats and may be due to an indirect mode of action. Prirbedil is also not reported to cause release or inhibition of tritium-labeled dopamine uptake in synaptosomes obtained from rat nucleus accumbens. Additionally, piribedil is reported to have an|in vitro|affinity to dopamine D3 receptor subtypes as evidenced by receptor binding autoradiography.
