Piroxicam - ≥98%(HPLC), high purity , CAS No.36322-90-4, Inhibitor of COX-1;Inhibitor of COX-2

2 Citations
Item Number
P129294
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P129294-1g
1g
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Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$64.90
P129294-5g
5g
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$140.90
P129294-25g
25g
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Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$634.90
P129294-100g
100g
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$2,284.90
P129294-500g
500g
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Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$10,278.90

Reversible, selective cyclooxygenase-1 (COX-1) inhibitor

View related series
COX-1 Inhibitor COX-2 Inhibitor

Basic Description

Synonyms4-Hydroxy-2-methyl-N-(pyridin-2-yl)-2H-benzo[e][1,2]thiazine-3-carboxamide 1,1-dioxide | 4-hydroxy-2-methyl-N-pyridin-2-yl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide | Artroxicam | BSPBio_000221 | CHEBI:8249 | Cyten | Felden | PIROXICAM (MART.) | PIRO
Specifications & PurityMoligand™, ≥98%(HPLC)
Biochemical and Physiological MechanismsPiroxicam is an effective and potent inhibitor of prostaglandin synthesis and a Cox-1 and Cox-2 inhibitor. Studies show that Piroxicam blocks release of platelet ADP, and inhibits Cox-1 (human prostaglandin H synthase isozyme-1, hPGHS-1) more potently tha
Storage TempStore at 2-8°C,Argon charged
Shipped InWet ice
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of COX-1;Inhibitor of COX-2
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Piroxicam is a non-selective COX inhibitor with an IC50 of 6 mM.
An inhibitor of prostaglandin synthesis as well as Cox-1 and Cox-2.

Associated Targets(Human)

PTGS1 Tclin Prostaglandin G/H synthase 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PTGS2 Tclin Prostaglandin G/H synthase 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-yl-1λ6,2-benzothiazine-3-carboxamide
INCHI InChI=1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20)
InChi Key QYSPLQLAKJAUJT-UHFFFAOYSA-N
Canonical SMILES CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=CC=CC=N3
Isomeric SMILES CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=CC=CC=N3
WGK Germany 3
RTECS DL0705000
PubChem CID 54676228
Molecular Weight 331.35
Beilstein 1876290

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot NumberCertificate TypeDateItem
F2214246Certificate of AnalysisMar 20, 2024 P129294
J2119553Certificate of AnalysisAug 17, 2023 P129294
J2119632Certificate of AnalysisAug 17, 2023 P129294
J2119637Certificate of AnalysisAug 17, 2023 P129294
J2119642Certificate of AnalysisAug 17, 2023 P129294
F1510086Certificate of AnalysisJan 20, 2023 P129294

Chemical and Physical Properties

SolubilitySoluble in water (Partly miscible), DMSO (25 mg/mL warm), ethanol (5 mg/mL warm), chloroform, ethyl acetate, DMF (~20 mg/mL), and 1:1 solution of DMSO:PBS(pH 7.2) (~0.5 mg/mL).
SensitivityHeat sensitive,air sensitive
Flash Point(°F)123.8 °F
Flash Point(°C)51 °C
Melt Point(°C)198-200°C

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS08
Signal Danger
Hazard Statements

H301:Toxic if swallowed

H372:Causes damage to organs through prolonged or repeated exposure

H360:May damage fertility or the unborn child

H361:Suspected of damaging fertility or the unborn child

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P203:Obtain, read and follow all safety instructions before use.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

P318:if exposed or concerned, get medical advice.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS DL0705000
Merck Index 7506

Related Documents

Citations of This Product

1. Lixue Ma, Zhaohua Li, Jiancheng Fei, Mo Li, Bingyang Liu, Baocheng Tian, Yanhua Liu, Qiang Fu.  (2023)  In vivo behaviors of meloxicam nanocrystals by intravenous administration are not significantly affected by stabilizers.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,  82  (104380).  [PMID:]
2. Fangwei Yang, Cheng Wang, Hang Yu, Yahui Guo, Yuliang Cheng, Weirong Yao, Yunfei Xie.  (2022)  Establishment of the thin-layer chromatography-surface-enhanced Raman spectroscopy and chemometrics method for simultaneous identification of eleven illegal drugs in anti-rheumatic health food.  Food Bioscience,  49  (101842).  [PMID:]

References

1. Lixue Ma, Zhaohua Li, Jiancheng Fei, Mo Li, Bingyang Liu, Baocheng Tian, Yanhua Liu, Qiang Fu.  (2023)  In vivo behaviors of meloxicam nanocrystals by intravenous administration are not significantly affected by stabilizers.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,  82  (104380).  [PMID:]
2. Fangwei Yang, Cheng Wang, Hang Yu, Yahui Guo, Yuliang Cheng, Weirong Yao, Yunfei Xie.  (2022)  Establishment of the thin-layer chromatography-surface-enhanced Raman spectroscopy and chemometrics method for simultaneous identification of eleven illegal drugs in anti-rheumatic health food.  Food Bioscience,  49  (101842).  [PMID:]

Solution Calculators