Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P129294-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $64.90 | |
P129294-5g | 5g | In stock | $140.90 | |
P129294-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $634.90 | |
P129294-100g | 100g | In stock | $2,284.90 | |
P129294-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $10,278.90 |
Reversible, selective cyclooxygenase-1 (COX-1) inhibitor
Synonyms | 4-Hydroxy-2-methyl-N-(pyridin-2-yl)-2H-benzo[e][1,2]thiazine-3-carboxamide 1,1-dioxide | 4-hydroxy-2-methyl-N-pyridin-2-yl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide | Artroxicam | BSPBio_000221 | CHEBI:8249 | Cyten | Felden | PIROXICAM (MART.) | PIRO |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Piroxicam is an effective and potent inhibitor of prostaglandin synthesis and a Cox-1 and Cox-2 inhibitor. Studies show that Piroxicam blocks release of platelet ADP, and inhibits Cox-1 (human prostaglandin H synthase isozyme-1, hPGHS-1) more potently tha |
Storage Temp | Store at 2-8°C,Argon charged |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of COX-1;Inhibitor of COX-2 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Piroxicam is a non-selective COX inhibitor with an IC50 of 6 mM. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | 4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-yl-1λ6,2-benzothiazine-3-carboxamide |
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INCHI | InChI=1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20) |
InChi Key | QYSPLQLAKJAUJT-UHFFFAOYSA-N |
Canonical SMILES | CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=CC=CC=N3 |
Isomeric SMILES | CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=CC=CC=N3 |
WGK Germany | 3 |
RTECS | DL0705000 |
PubChem CID | 54676228 |
Molecular Weight | 331.35 |
Beilstein | 1876290 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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F2214246 | Certificate of Analysis | Mar 20, 2024 | P129294 |
J2119553 | Certificate of Analysis | Aug 17, 2023 | P129294 |
J2119632 | Certificate of Analysis | Aug 17, 2023 | P129294 |
J2119637 | Certificate of Analysis | Aug 17, 2023 | P129294 |
J2119642 | Certificate of Analysis | Aug 17, 2023 | P129294 |
F1510086 | Certificate of Analysis | Jan 20, 2023 | P129294 |
Solubility | Soluble in water (Partly miscible), DMSO (25 mg/mL warm), ethanol (5 mg/mL warm), chloroform, ethyl acetate, DMF (~20 mg/mL), and 1:1 solution of DMSO:PBS(pH 7.2) (~0.5 mg/mL). |
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Sensitivity | Heat sensitive,air sensitive |
Flash Point(°F) | 123.8 °F |
Flash Point(°C) | 51 °C |
Melt Point(°C) | 198-200°C |
Pictogram(s) | GHS06, GHS08 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed H372:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | DL0705000 |
Merck Index | 7506 |