PKI-179 - ≥98%, high purity , PI3-kinase p110-alpha subunit inhibitor, CAS No.1197160-28-3, PI3-kinase p110-alpha subunit inhibitor

Item Number

P345208

• Synonyms: PKI-179 | 1-{4-[4-morpholin-4-yl-6-(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]phenyl}-3-pyridin-4-ylurea | BDBM50327419 | 1-[4-[4-morpholin-4-yl-6-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-1,3,5-triazin-2-yl]phenyl]-3-pyridin-4-ylurea | CS-0003039
• Specifications & Purity: ≥98%
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice
• Action Type: INHIBITOR
• Mechanism of action: PI3-kinase p110-alpha subunit inhibitor

Product Description

PKI-179 is a cell-permeable triazinyl-phenyl-pyridinylurea compound that acts as a potent inhibitor against mTOR (IC50 = 0.42 nM) and PI 3-K (IC50 = 8, 24, 74, 77, 14, and 11 nM against isoform α, β, γ, δ, α E545K mutant, and α H1047R mutant, respectively) activities, exhibiting much reduced or little activity against a panel of 361 other kinases (IC50 >50 μM), Cytochrome CYP isoforms, or hERG. PKI-179 is reported to effectively suppress cancer growth in cultures in vitro (IC50 = 22 and 29 nM, respectively, against MDA361 and PC3mm2) via apoptosis induction as a result of Akt/mTOR pathway inhibition.