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Plerixafor 8HCl (AMD3100 8HCl) - ≥99%, high purity , CAS No.155148-31-5

  • ≥99%
Item Number
P129846
Grouped product items
SKUSizeAvailabilityPrice Qty
P129846-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$49.90
P129846-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$82.90
P129846-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$186.90
P129846-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$215.90
P129846-250mg
250mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$972.90
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Highly selective CXCR4 antagonist

Basic Description

Synonyms155148-31-5 (HCl) | Plerixafor hydrochloride | AMD3100 octahydrochloride hydrate | DTXSID20935148 | 1,1'-[1,4-Phenylenebis-(methylene)]-bis-(1,4,8,11-tetraazacyclotetradecane) octahydrochloride | Sid 791 | PLERIXAFOR OCTAHYDROCHLORIDE [WHO-DD] | AMD 3100
Specifications & Purity≥99%
Biochemical and Physiological MechanismsAMD3100 octahydrochloride is a selective bicyclam derivative which functions as a stem cell mobiliser via blocking the CXCR4 chemokine receptor. Studies suggest that AMD3100 octahydrochloride causes the rapid movement of stem cells out of bone marrow via
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Plerixafor 8HCl (AMD3100 8HCl) is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.
A specific CXCR4 antagonist.

Associated Targets(Human)

KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CXCR4 Tclin C-X-C chemokine receptor type 4 (3338 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCR3 Tchem C-C chemokine receptor type 3 (1666 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCR5 Tclin C-C chemokine receptor type 5 (5640 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MT4 (17854 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACKR3 Tchem C-X-C chemokine receptor type 7 (1102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human immunodeficiency virus 1 (70413 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane;octahydrochloride
INCHI InChI=1S/C28H54N8.8ClH/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36;;;;;;;;/h5-8,29-34H,1-4,9-26H2;8*1H
InChi Key UEUPDYPUTTUXLJ-UHFFFAOYSA-N
Canonical SMILES C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3.Cl.Cl.Cl.Cl.Cl.Cl.Cl.Cl
Isomeric SMILES C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3.Cl.Cl.Cl.Cl.Cl.Cl.Cl.Cl
PubChem CID 65014
Molecular Weight 794.47

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot NumberCertificate TypeDateItem
L2117239Certificate of AnalysisOct 07, 2023 P129846
L2117240Certificate of AnalysisOct 07, 2023 P129846
L2117241Certificate of AnalysisOct 07, 2023 P129846

Chemical and Physical Properties

SolubilitySolubility H2O: ≥10 mg/mL, clear；DMSO：Insoluble；Ethanol：Insoluble
Sensitivityheat sensitive
Melt Point(°C)245 °C

Related Documents

 SDS

 Specification Sheet

References

1. Lu W et al..  (2019)  AMD3100 Attenuates Post-Traumatic Osteoarthritis by Maintaining Transforming Growth Factor-ß1-Induced Expression of Tissue Inhibitor of Metalloproteinase-3 via the Phosphatidylinositol 3-Kinase/Akt Pathway..  Front Pharmacol,  10  (1554).  [PMID:32038242]
2. Li B et al..  (2018)  AMD3100 Augments the Efficacy of Mesothelin-Targeted, Immune-Activating VIC-008 in Mesothelioma by Modulating Intratumoral Immunosuppression..  Cancer Immunol Res,  6  (5): (539-551).  [PMID:29511032]
3. Negro S et al..  (2019)  An Agonist of the CXCR4 Receptor Strongly Promotes Regeneration of Degenerated Motor Axon Terminals..  Cells,  8  (10):   [PMID:31575088]
4. Ito N et al..  (2020)  Biphasic MIF and SDF1 expression during podocyte injury promote CD44-mediated glomerular parietal cell migration in focal segmental glomerulosclerosis..  Am J Physiol Renal Physiol,  318  (3): (F741-F753).  [PMID:32068458]
5. Lu W et al..  (2016)  CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model..  Int J Mol Sci,  17  (10):   [PMID:27690009]
6. Du LL & Liu P.  (2016)  CXCL12/CXCR4 axis regulates neovascularization and lymphangiogenesis in sutured corneas in mice..  Mol Med Rep,  13  (6): (4987-94).  [PMID:27121088]
7. Zeng Y et al..  (2019)  Dual blockade of CXCL12-CXCR4 and PD-1-PD-L1 pathways prolongs survival of ovarian tumor-bearing mice by prevention of immunosuppression in the tumor microenvironment..  FASEB J,  33  (5): (6596-6608).  [PMID:30802149]
8. Zhou H et al..  (2015)  Effects of Exendin-4 on bone marrow mesenchymal stem cell proliferation, migration and apoptosis in vitro..  Sci Rep,  5  (12898).  [PMID:26250571]
9. Li B et al..  (2018)  Epigenetic Regulation of CXCL12 Plays a Critical Role in Mediating Tumor Progression and the Immune Response In Osteosarcoma..  Cancer Res,  78  (14): (3938-3953).  [PMID:29735547]
10. Zhou H et al..  (2015)  Exendin-4 enhances the migration of adipose-derived stem cells to neonatal rat ventricular cardiomyocyte-derived conditioned medium via the phosphoinositide\xa03-kinase/Akt-stromal cell-derived factor-1a/CXC chemokine receptor 4 pathway..  Mol Med Rep,  11  (6): (4063-72).  [PMID:25625935]
11. Hirata K et al..  (2019)  Exocrine tissue-driven TFF2 prevents apoptotic cell death of endocrine lineage during pancreas organogenesis..  Sci Rep,  9  (1636).  [PMID:30733468]
12. Qin H et al..  (2021)  Inhibition of SDF-1/CXCR4 Axis to Alleviate Abnormal Bone Formation and Angiogenesis Could Improve the Subchondral Bone Microenvironment in Osteoarthritis..  Biomed Res Int,  2021  (8852574).  [PMID:34136574]
13. Lin YN et al..  (2022)  Impaired CXCL12 signaling contributes to resistance of pancreatic cancer subpopulations to T cell-mediated cytotoxicity..  Oncoimmunology,  11  (2027136).  [PMID:35127250]
14. Iseki M et al..  (2017)  Muse Cells, Nontumorigenic Pluripotent-Like Stem Cells, Have Liver Regeneration Capacity Through Specific Homing and Cell Replacement in a Mouse Model of Liver Fibrosis..  Cell Transplant,  26  (5): (821-840).  [PMID:27938474]
15. Cugurra A et al..  (2021)  Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma..  Science,  373  (6553):   [PMID:34083447]
16. Morioka N et al..  (2019)  Spinal high-mobility group box-1 induces long-lasting mechanical hypersensitivity through the toll-like receptor 4 and upregulation of interleukin-1ß in activated astrocytes..  J Neurochem,  150  (6): (738-758).  [PMID:31273787]
17. Qin HJ et al..  (2019)  SDF-1/CXCR4 axis coordinates crosstalk between subchondral bone and articular cartilage in osteoarthritis pathogenesis..  Bone,  125  (140-150).  [PMID:31108241]
18. Yang F et al..  (2017)  SDF1-CXCR4 Signaling Maintains Central Post-Stroke Pain through Mediation of Glial-Neuronal Interactions..  Front Mol Neurosci,  10  (226).  [PMID:28785202]
19. Ding Q et al..  (2019)  Stemona alkaloids suppress the positive feedback loop between M2 polarization and fibroblast differentiation by inhibiting JAK2/STAT3 pathway in fibroblasts and CXCR4/PI3K/AKT1 pathway in macrophages..  Int Immunopharmacol,  72  (385-394).  [PMID:31030094]
20. Umezu K et al..  (2020)  Stromal cell-derived factor 1 regulates in vitro sperm migration towards the cumulus-oocyte complex in cattle..  PLoS One,  15  (4): (e0232536).  [PMID:32353075]
21. Miao G et al..  (2020)  TLR2/CXCR4 coassociation facilitates Chlamydia pneumoniae infection-induced atherosclerosis..  Am J Physiol Heart Circ Physiol,  318  (6): (H1420-H1435).  [PMID:32330088]
22. Lee IP et al..  (2014)  Toxoplasma gondii is dependent on glutamine and alters migratory profile of infected host bone marrow derived immune cells through SNAT2 and CXCR4 pathways..  PLoS One,  9  (10): (e109803).  [PMID:25299045]
23. Jung O et al..  (2019)  VLA-4 phosphorylation during tumor and immune cell migration relies on its coupling to VEGFR2 and CXCR4 by syndecan-1..  J Cell Sci,  132  (20):   [PMID:31562188]

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