Plerixafor is a stem cell activator, and CXCR4 chemokine antagonis, Drug treatment of myeloma.
Storage Temp
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
AGONIST, ANTAGONIST, PARTIAL AGONIST
Mechanism of action
C-X-C chemokine receptor type 4 partial agonist
Product Description
Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively. IC50 value: 44 nM (CXCR4); 5.7 nM (CXCL12-mediated chemotaxis) Target: CXCR4
Associated Targets
CXCR4Tclin C-X-C chemokine receptor type 4 14 Activities
1.Zhang WB, Navenot JM, Haribabu B, Tamamura H, Hiramatu K, Omagari A, Pei G, Manfredi JP, Fujii N, Broach JR, Peiper SC. (2002) A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists.. J Biol Chem, 277 (3):(24515-24521). [PMID:11923301]
2.Hatse S, Princen K, Bridger G, De Clercq E, Schols D. (2002) Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4.. FEBS Lett, 527 (1-3):(255-62). [PMID:12220670]
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F2218059
