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Plinabulin (NPI-2358) - 10mM in DMSO, high purity , CAS No.714272-27-2
Basic Description Synonyms TRIBENOSIDE [MI] | DB05992 | 986FY7F8XR | HMS3884P14 | plinabulinum | Dibenzyl N, N-diisopropyl-phosphoramidite | Plinabulin(NPI-2358) | 2,5-Piperazinedione, 3-((5-(1,1-dimethylethyl)-1H-imidazol-4-yl)methylene)-6-(phenylmethylene)-, (3Z,6Z)- | BPI 2358 | Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms NPI-2358 (Plinabulin) is a novel vascular disrupting agent (VDA) with an IC50 of 15 nM against HT-29 cells. NPI-2358 binds to the colchicine-binding site of tubulin. NPI-2358 has potent in-vitro anti-tumor activity against various human t
Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 1/2.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione INCHI InChI=1S/C19H20N4O2/c1-19(2,3)16-13(20-11-21-16)10-15-18(25)22-14(17(24)23-15)9-12-7-5-4-6-8-12/h4-11H,1-3H3,(H,20,21)(H,22,25)(H,23,24)/b14-9-,15-10- InChi Key UNRCMCRRFYFGFX-TYPNBTCFSA-N Canonical SMILES CC(C)(C)C1=C(N=CN1)C=C2C(=O)NC(=CC3=CC=CC=C3)C(=O)N2 Isomeric SMILES CC(C)(C)C1=C(N=CN1)/C=C\2/C(=O)N/C(=C\C3=CC=CC=C3)/C(=O)N2 PubChem CID 9949641 Molecular Weight 336.39
Citations of This Product 1. Shengrong Liao,Xiaochu Qin,Ding Li,Zhengchao Tu,Jinsheng Li,Xuefeng Zhou,Junfeng Wang,Bin Yang,Xiuping Lin,Juan Liu,Xianwen Yang,Yonghong Liu. (2014-06-25) Design and synthesis of novel soluble 2,5-diketopiperazine derivatives as potential anticancer agents.. European journal of medicinal chemistry, 83 (236-244). [PMID:24960627 ]
References 1. Shengrong Liao,Xiaochu Qin,Ding Li,Zhengchao Tu,Jinsheng Li,Xuefeng Zhou,Junfeng Wang,Bin Yang,Xiuping Lin,Juan Liu,Xianwen Yang,Yonghong Liu. (2014-06-25) Design and synthesis of novel soluble 2,5-diketopiperazine derivatives as potential anticancer agents.. European journal of medicinal chemistry, 83 (236-244). [PMID:24960627 ]
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