Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P170552-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $17.90 | |
P170552-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $34.90 | |
P170552-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $105.90 | |
P170552-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $474.90 |
Anticancer and anti-inflammatory agent
Synonyms | 5-Hydroxy-2-methyl-1,4-naphthalenedione | 5-Hydroxy-2-methyl-1,4-naphthoquinone | BRD-K36137799-001-02-4 | CCG-208410 | NSC-236613 | Plumbagin | Plumbagine | NCGC00094567-01 | s4777 | NCI60_001904 | SCHEMBL34186 | NCGC00094567-04 | GTPL7003 | ST069355 | N |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Exhibits cytotoxicity in rodent models of carcinogenesis and carcinoma; has antifungal, antiviral, and antibacterial action. Plumbagin exhibits cytotoxicity in rodent models of carcinogenesis and carcinoma. Plumbagin is a unique suppressor of CXCR4 expres |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of E1A binding protein p300;Inhibitor of lysine acetyltransferase 2B |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Plumbagin, a quinoid constituent isolated from the root of the medicinal plant Plumbago zeylanica L, exerts anticancer and antiproliferative activities in animal models and in cell culture. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 5-hydroxy-2-methylnaphthalene-1,4-dione |
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INCHI | InChI=1S/C11H8O3/c1-6-5-9(13)10-7(11(6)14)3-2-4-8(10)12/h2-5,12H,1H3 |
InChi Key | VCMMXZQDRFWYSE-UHFFFAOYSA-N |
Canonical SMILES | CC1=CC(=O)C2=C(C1=O)C=CC=C2O |
Isomeric SMILES | CC1=CC(=O)C2=C(C1=O)C=CC=C2O |
PubChem CID | 10205 |
Molecular Weight | 188.18 |
PubChem CID | 10205 |
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CAS Registry No. | 481-42-5 |
ChEMBL Ligand | CHEMBL295316 |
Wikipedia | Plumbagin |
ChEBI | CHEBI:8273 |
RCSB PDB Ligand | 90R |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
L2102052 | Certificate of Analysis | Sep 19, 2024 | P170552 |
L2102053 | Certificate of Analysis | Sep 19, 2024 | P170552 |
L2102054 | Certificate of Analysis | Sep 19, 2024 | P170552 |
I2202046 | Certificate of Analysis | Aug 08, 2022 | P170552 |
I2202048 | Certificate of Analysis | Aug 08, 2022 | P170552 |
I2202092 | Certificate of Analysis | Aug 08, 2022 | P170552 |
I2202108 | Certificate of Analysis | Aug 08, 2022 | P170552 |
Solubility | Solubility in hot Methanol very faint turbidity |
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Sensitivity | Moisture sensitive |
Melt Point(°C) | 76-79 °C |
Pictogram(s) | GHS06, GHS05 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed H314:Causes severe skin burns and eye damage |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P363:Wash contaminated clothing before reuse. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes. P316:Get emergency medical help immediately. |
Merck Index | 7538 |
1. Lijie Zhang, Dongxue Liang, Linlin Liu, Lihua Liu. (2023) Plumbagin alleviates obesity-related asthma: Targeting inflammation, oxidative stress, and the AMPK pathway. Immunity Inflammation and Disease, 11 (9): (e1025). [PMID:37773696] [10.1002/iid3.1025] |
2. Wenzhe Xu, Yang Chen, Ruixu Yang, Yiying Fu, Wanxin Zhuang, Yonggang Wang, Yi Liu, Hao Zhang. (2023) “Reaction”-Like Shaping of Self-Delivery Supramolecular Nanodrugs in the Nanoprecipitation Process. ACS Nano, 17 (18): (18227–18239). [PMID:37668306] [10.1021/acsnano.3c05229] |
3. Mengsi Zhang, Lu Wang, Hao Jin, Nan Zhao, Yi Liu, Shijie Lan, Shuwei Liu, Hao Zhang. (2023) Employing single valency polyphenol to prepare metal-phenolic network antitumor reagents through FeOOH assistance. JOURNAL OF CONTROLLED RELEASE, 358 (612). [PMID:37196899] [10.1016/j.jconrel.2023.05.020] |
4. Yang Wang, Xin Sun, Yi Wang. (2022) Synthesis of pH-responsive covalent organic frameworks nanocarrier for plumbagin delivery. RSC Advances, 12 (25): (16046-16050). [PMID:35733662] [10.1039/D2RA03127B] |
1. Dahlin JL, Nelson KM, Strasser JM, Barsyte-Lovejoy D, Szewczyk MM, Organ S, Cuellar M, Singh G, Shrimp JH, Nguyen N et al.. (2017) Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors.. Nat Commun, 8 (1): (1527). [PMID:29142305] [10.1021/op500134e] |
2. Lijie Zhang, Dongxue Liang, Linlin Liu, Lihua Liu. (2023) Plumbagin alleviates obesity-related asthma: Targeting inflammation, oxidative stress, and the AMPK pathway. Immunity Inflammation and Disease, 11 (9): (e1025). [PMID:37773696] [10.1002/iid3.1025] |
3. Wenzhe Xu, Yang Chen, Ruixu Yang, Yiying Fu, Wanxin Zhuang, Yonggang Wang, Yi Liu, Hao Zhang. (2023) “Reaction”-Like Shaping of Self-Delivery Supramolecular Nanodrugs in the Nanoprecipitation Process. ACS Nano, 17 (18): (18227–18239). [PMID:37668306] [10.1021/acsnano.3c05229] |
4. Mengsi Zhang, Lu Wang, Hao Jin, Nan Zhao, Yi Liu, Shijie Lan, Shuwei Liu, Hao Zhang. (2023) Employing single valency polyphenol to prepare metal-phenolic network antitumor reagents through FeOOH assistance. JOURNAL OF CONTROLLED RELEASE, 358 (612). [PMID:37196899] [10.1016/j.jconrel.2023.05.020] |
5. Yang Wang, Xin Sun, Yi Wang. (2022) Synthesis of pH-responsive covalent organic frameworks nanocarrier for plumbagin delivery. RSC Advances, 12 (25): (16046-16050). [PMID:35733662] [10.1039/D2RA03127B] |