PLX-4720 - ≥99%, high purity , CAS No.918505-84-7, Inhibitor of B-Raf proto-oncogene; serine/threonine kinase;Inhibitor of kinase insert domain receptor
PLX-4720 - ≥99%, high purity , CAS No.918505-84-7, Inhibitor of B-Raf proto-oncogene; serine/threonine kinase;Inhibitor of kinase insert domain receptor
PLX-4720 is a B-raf inhibitor with IC50 of 160 nM.Potent B-Raf inhibitor (IC 50 values are 6.7, 13 and 160 nM for C-Raf-1 Y340D/Y341D , B-Raf V600E and B-Raf wild-type respectively). Shows antiproliferative effects. Shows antitumor effects in vivo. Orally
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of B-Raf proto-oncogene; serine/threonine kinase;Inhibitor of kinase insert domain receptor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
1.Tsai J, Lee JT, Wang W, Zhang J, Cho H, Mamo S, Bremer R, Gillette S, Kong J, Haass NK et al.. (2008) Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity.. Proc Natl Acad Sci USA, 105 (8):(3041-6). [PMID:18287029]
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D1803139