pAb; Rabbit anti Human PMS2 Antibody; WB, IHC; Unconjugated
| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab122454-10μl | 10μl | In stock | $66.90 | |
| Ab122454-50μl | 50μl | In stock | $189.90 | |
| Ab122454-100μl | 100μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $299.90 | |
| Ab122454-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,599.90 |
pAb; Rabbit anti Human PMS2 Antibody; WB, IHC; Unconjugated
| Product Name | PMS2 Antibody - Primary antibody, specific to PMS2, Rabbit IgG |
|---|---|
| Synonyms | DNA mismatch repair gene homologueantibody; DNA mismatch repair protein PMS2 antibody; H_DJ0042M02.9 antibody; HNPCC4 antibody; Mismatch repair endonuclease PMS2 antibody; Mismatch repair gene PMSL2 antibody; MLH4 antibody; PMS 2 antibody; PMS1 homolog 2 |
| Specifications & Purity | ExactAb™, Validated, 0.5 mg/mL |
| Host species | Rabbit |
| Specificity | PMS2 |
| Immunogen | A synthetic peptide derived from human PMS2 (AA 9-24) |
| Positive Control | WB: Jurkat, HeLa and SK-N-SH cell lysates. IHC: Human tonsil tissue. |
| Conjugation | Unconjugated |
| Grade | ExactAb™, Validated |
| Product Description | Rabbit anti Human PMS2 Antibody, Polyclonal, could be used for WB, IHC and so on. |
| Isotype | Rabbit IgG |
|---|---|
| SDS-PAGE | 150 kDa |
| Purification Method | Protein A purified |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle. |
PMS2 Antibody (Ab122454) - Western Blot
All lanes: PMS2 Antibody (Ab122454) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 96 kDa
Observed band size: 48, 54, 107 kDa
Exposure time: 16.5 s
PMS2 Antibody (Ab122454) - IHC
Immunohistochemistry analysis of paraffin-embedded Human tonsil using PMS2 Antibody (Ab122454). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Application | Dilution info |
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50 - 1/100 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ24F0404020 | Certificate of Analysis | Apr 01, 2024 | Ab122454 |
| ZJ24F0404019 | Certificate of Analysis | Apr 01, 2024 | Ab122454 |
| 1. Hamilton, S R SR and 9 more authors.. (1995) The molecular basis of Turcot's syndrome.. The New England journal of medicine, (30): [PMID:7661930] |
| 2. Nicolaides, N C NC and 9 more authors.. (1994) Mutations of two PMS homologues in hereditary nonpolyposis colon cancer.. Nature, (1): [PMID:8072530] |
| 3. Miyaki, M M and 15 more authors.. (1997) Drastic genetic instability of tumors and normal tissues in Turcot syndrome.. Oncogene, (4): [PMID:9419979] |
| 4. Wang, Q Q and 10 more authors.. () Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, hPMS2, and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal cancer.. Human genetics, [PMID:10480359] |
| 5. Wang, Y Y and 5 more authors.. (2000) BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.. Genes & development, (15): [PMID:10783165] |
| 6. Guarné, A A, Junop, M S MS and Yang, W W.. (2001) Structure and function of the N-terminal 40 kDa fragment of human PMS2: a monomeric GHL ATPase.. The EMBO journal, (1): [PMID:11574484] |
| 7. Yuan, Zi Qiang ZQ and 8 more authors.. (2002) Polymorphisms and HNPCC: PMS2-MLH1 protein interactions diminished by single nucleotide polymorphisms.. Human mutation, [PMID:11793469] |
| 8. Hillier, Ladeana W LW and 106 more authors.. (2003) The DNA sequence of human chromosome 7.. Nature, (10): [PMID:12853948] |
| 9. De Vos, Michel M, Hayward, Bruce E BE, Picton, Susan S, Sheridan, Eamonn E and Bonthron, David T DT.. (2004) Novel PMS2 pseudogenes can conceal recessive mutations causing a distinctive childhood cancer syndrome.. American journal of human genetics, [PMID:15077197] |
| 10. Worthley, Daniel L DL and 6 more authors.. (2005) Familial mutations in PMS2 can cause autosomal dominant hereditary nonpolyposis colorectal cancer.. Gastroenterology, [PMID:15887124] |
| 11. Constantin, Nicoleta N, Dzantiev, Leonid L, Kadyrov, Farid A FA and Modrich, Paul P.. (2005) Human mismatch repair: reconstitution of a nick-directed bidirectional reaction.. The Journal of biological chemistry, (2): [PMID:16188885] |
| 12. Hendriks, Yvonne M C YM and 13 more authors.. (2006) Heterozygous mutations in PMS2 cause hereditary nonpolyposis colorectal carcinoma (Lynch syndrome).. Gastroenterology, [PMID:16472587] |
| 13. Clendenning, Mark M and 8 more authors.. (2006) Long-range PCR facilitates the identification of PMS2-specific mutations.. Human mutation, [PMID:16619239] |
| 14. and Jiricny, Josef J.. (2006) MutLalpha: at the cutting edge of mismatch repair.. Cell, (28): [PMID:16873053] |
| 15. Kadyrov, Farid A FA, Dzantiev, Leonid L, Constantin, Nicoleta N and Modrich, Paul P.. (2006) Endonucleolytic function of MutLalpha in human mismatch repair.. Cell, (28): [PMID:16873062] |
| 16. Auclair, Jessie J and 12 more authors.. (2007) Novel biallelic mutations in MSH6 and PMS2 genes: gene conversion as a likely cause of PMS2 gene inactivation.. Human mutation, [PMID:17557300] |
| 17. and Li, Guo-Min GM.. (2008) Mechanisms and functions of DNA mismatch repair.. Cell research, [PMID:18157157] |
| 18. Clendenning, M M and 11 more authors.. (2008) A frame-shift mutation of PMS2 is a widespread cause of Lynch syndrome.. Journal of medical genetics, [PMID:18178629] |
| 19. Sacho, Elizabeth J EJ, Kadyrov, Farid A FA, Modrich, Paul P, Kunkel, Thomas A TA and Erie, Dorothy A DA.. (2008) Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alpha.. Molecular cell, (18): [PMID:18206974] |
| 20. Senter, Leigha L and 17 more authors.. (2008) The clinical phenotype of Lynch syndrome due to germ-line PMS2 mutations.. Gastroenterology, [PMID:18602922] |
| 21. Montazer Haghighi, Mahdi M and 5 more authors.. (2009) Four novel germline mutations in the MLH1 and PMS2 mismatch repair genes in patients with hereditary nonpolyposis colorectal cancer.. International journal of colorectal disease, [PMID:19479271] |
| 22. Ganster, Christina C and 9 more authors.. (2010) Functional PMS2 hybrid alleles containing a pseudogene-specific missense variant trace back to a single ancient intrachromosomal recombination event.. Human mutation, [PMID:20186689] |
| 23. Smogorzewska, Agata A and 10 more authors.. (2010) A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.. Molecular cell, (9): [PMID:20603073] |
| 24. Borràs, Ester E and 15 more authors.. (2013) Refining the role of PMS2 in Lynch syndrome: germline mutational analysis improved by comprehensive assessment of variants.. Journal of medical genetics, [PMID:23709753] |
| 25. Drost, Mark M, Koppejan, Hester H and de Wind, Niels N.. (2013) Inactivation of DNA mismatch repair by variants of uncertain significance in the PMS2 gene.. Human mutation, [PMID:24027009] |
| 26. van der Klift, Heleen M HM and 24 more authors.. (2016) Comprehensive Mutation Analysis of PMS2 in a Large Cohort of Probands Suspected of Lynch Syndrome or Constitutional Mismatch Repair Deficiency Syndrome.. Human mutation, [PMID:27435373] |
| 27. Arora, Sanjeevani S and 10 more authors.. (2017) Functional analysis of rare variants in mismatch repair proteins augments results from computation-based predictive methods.. Cancer biology & therapy, (3): [PMID:28494185] |
| 28. de Barros, Andrea C AC and 5 more authors.. (2018) DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway.. Biochimie, [PMID:29175432] |
| 29. D'Arcy, Brandon M BM, Blount, Jessa J and Prakash, Aishwarya A.. (2019) Biochemical and structural characterization of two variants of uncertain significance in the PMS2 gene.. Human mutation, [PMID:30653781] |
