PND-1186 - ≥98%, high purity , Focal adhesion kinase 1 inhibitor, CAS No.1061353-68-1, Focal adhesion kinase 1 inhibitor

Item Number
P126394
Grouped product items
SKUSizeAvailabilityPrice Qty
P126394-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$129.90
P126394-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$585.90
P126394-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$652.90

Potent FAK inhibitor

Basic Description

Synonyms2-((2-((2-methoxy-4-morpholinophenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide. | Q27089163 | SCHEMBL47360 | 2-(2-(2-Methoxy-4-morpholinophenylamino)-5-(trifluoromethyl)pyridine-4-ylamino)-N-methylbenzamide | PND-1186 (VS-4718) | MFC
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsPotent FAK inhibitor (IC50values are 1.5 and 100 nM for recombinant FAK and FAK in breast carcinoma cells, respectively). Promotes caspase activation; triggering apoptosis. Inhibits 4T1 breast carcinoma subcutaneous tumor growth and breast carcinoma cell
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionFocal adhesion kinase 1 inhibitor
Note卖完停产,不再备货
Product Description

PND-1186 is a potent FAK inhibitor with IC50 of 1.5 nM.

Product Properties

ALogP4.7

Associated Targets(Human)

PTK2 Tclin Focal adhesion kinase 1 (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 2-[[2-(2-methoxy-4-morpholin-4-ylanilino)-5-(trifluoromethyl)pyridin-4-yl]amino]-N-methylbenzamide
INCHI InChI=1S/C25H26F3N5O3/c1-29-24(34)17-5-3-4-6-19(17)31-21-14-23(30-15-18(21)25(26,27)28)32-20-8-7-16(13-22(20)35-2)33-9-11-36-12-10-33/h3-8,13-15H,9-12H2,1-2H3,(H,29,34)(H2,30,31,32)
InChi Key IGUBBWJDMLCRIK-UHFFFAOYSA-N
Canonical SMILES CNC(=O)C1=CC=CC=C1NC2=CC(=NC=C2C(F)(F)F)NC3=C(C=C(C=C3)N4CCOCC4)OC
Isomeric SMILES CNC(=O)C1=CC=CC=C1NC2=CC(=NC=C2C(F)(F)F)NC3=C(C=C(C=C3)N4CCOCC4)OC
PubChem CID 25073775
Molecular Weight 501.5

Certificates

Certificate of Analysis(COA)

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Lot NumberCertificate TypeDateItem
F1702060Certificate of AnalysisJan 19, 2023 P126394

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 50.15, Max Conc. mM: 100

Related Documents

References

1. Tanjoni I, Walsh C, Uryu S, Tomar A, Nam JO, Mielgo A, Lim ST, Liang C, Koenig M, Sun C et al..  (2010)  PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments..  Cancer Biol Ther,  (10): (764-77).  [PMID:20234191] [10.1021/op500134e]
2. Tancioni I, Uryu S, Sulzmaier FJ, Shah NR, Lawson C, Miller NL, Jean C, Chen XL, Ward KK, Schlaepfer DD.  (2014)  FAK Inhibition disrupts a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth..  Mol Cancer Ther,  13  (8): (2050-61).  [PMID:24899686] [10.1021/op500134e]
3. Lee BY, Timpson P, Horvath LG, Daly RJ.  (2015)  FAK signaling in human cancer as a target for therapeutics..  Pharmacol Ther,  146  (13): (132-49).  [PMID:25316657] [10.1021/op500134e]

Solution Calculators