PNU-120596 - ≥98% (HPLC), high purity , CAS No.501925-31-1, Allosteric modulator of nicotinic acetylcholine receptor α7 subunit

Item Number

P125212

• Synonyms: 501925-31-1|PNU-120596|1-(5-Chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea|PNU 120596|PNU120596|NSC 216666|N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA|1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-1,2-oxazol-3-yl)urea|9EZT3P
• Specifications & Purity: Moligand™, ≥98%(HPLC)
• Biochemical and Physiological Mechanisms: PNU 120596 is a type II positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor (AChR) located on the somatodendritic membrane of hippocampal interneurons. This modulator increases the frequency of acetylcholine-evoked GABAergic post
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ALLOSTERIC MODULATOR
• Mechanism of action: Allosteric modulator of nicotinic acetylcholine receptor α7 subunit
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.
A type II positive allosteric modulator.