PNU 282987 - ≥98%(HPLC), high purity , CAS No.711085-63-1, Agonist of nicotinic acetylcholine receptor α7 subunit

Item Number

P288832

• Synonyms: 711085-63-1 | PNU-282987 | 123464-89-1 | PNU282987 | Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro- | PNU 282987 | PNU-282987 free base | (R)-4-chloro-N-(quinuclidin-3-yl)benzamide | N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-4-chlorobenzamide | PNU-282987 (free base)
• Specifications & Purity: Moligand™, ≥98%(HPLC)
• Biochemical and Physiological Mechanisms: Highly selectiveα7 nAChR agonist (Ki= 26 nM) displaying negligible blockade ofα1β1γδandα3β4nAChRs (IC50≥ 60μM). Found to be inactive against a panel of 32 receptors at 1μM, except 5-HT3receptors (Ki= 930 nM).
• Storage Temp: Store at -20°C,Argon charged
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: AGONIST
• Mechanism of action: Agonist of nicotinic acetylcholine receptor α7 subunit

Product Description

Product description：

PNU-282987 (free base) is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 (free base) is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 (free base) can be used for the research of central and peripheral nervous systems.