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PNU 282987 - ≥98%(HPLC), high purity , CAS No.711085-63-1, Agonist of nicotinic acetylcholine receptor α7 subunit
Selective α7 nAChR agonist
Basic Description Synonyms 711085-63-1|PNU-282987|123464-89-1|PNU282987|Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-|PNU 282987|PNU-282987 free base|(R)-4-chloro-N-(quinuclidin-3-yl)benzamide|N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-4-chlorobenzamide|PNU-282987 (free base) Specifications & Purity ≥98%(HPLC) Storage Temp Store at -20°C,Argon charged Shipped In Ice chest + Ice pads Grade Moligand™ Action Type AGONIST Mechanism of action Agonist of nicotinic acetylcholine receptor α7 subunit Product Description Product description：
PNU-282987 (free base) is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 (free base) is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 (free base) can be used for the research of central and peripheral nervous systems.
Names and Identifiers IUPAC Name N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-4-chlorobenzamide INCHI InChI=1S/C14H17ClN2O/c15-12-3-1-11(2-4-12)14(18)16-13-9-17-7-5-10(13)6-8-17/h1-4,10,13H,5-9H2,(H,16,18)/t13-/m0/s1 InChi Key WECKJONDRAUFDD-ZDUSSCGKSA-N Canonical SMILES C1CN2CCC1C(C2)NC(=O)C3=CC=C(C=C3)Cl Isomeric SMILES C1CN2CCC1[C@H](C2)NC(=O)C3=CC=C(C=C3)Cl PubChem CID 9795278 Molecular Weight 264.75
Chemical and Physical Properties Solubility Solvent:1eq. HCl, Max Conc. mg/mL: 26.48, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 26.48, Max Conc. mM: 100 Sensitivity Air Sensitive Melt Point(°C) 168 °C
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F2306092