Poly-L-proline - mol wt >30,000, high purity , CAS No.25191-13-3

  • mol wt >30,000
Item Number
P477766
Grouped product items
SKUSizeAvailabilityPrice Qty
P477766-50mg
50mg
In stock
$668.90
P477766-100mg
100mg
In stock
$1,068.90

Basic Description

Synonymspyrrolidine-2-carboxylic acid | 2-PYRROLIDINYLCARBOXYLIC ACID | BCP26673 | DL-Proline | FT-0605174 | J-300219 | NSC 97923 | DCS9E77JPQ | AKOS000119715 | FT-0659337 | SY001352 | (2R)-pyrrolidin-1-ium-2-carboxylate;DL-Proline | AKOS016182584 | BDBM50000105
Specifications & Puritymol wt >30,000
Storage TempStore at -20°C
Shipped InIce chest + Ice pads

Associated Targets(Human)

RUNX1 Tbio Runt-related transcription factor 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
POLK Tbio DNA polymerase kappa (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIN1 Tclin Glutamate receptor ionotropic, NMDA 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A498 (42825 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHN (49357 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
COLO 205 (50209 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DU-145 (51482 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
K562 (73714 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KM12 (47707 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
M14 (47487 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MOLT-4 (49676 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-3 (48710 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-4 (44535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-5 (45555 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-8 (47708 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-3 (62116 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RPMI-8226 (44974 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RXF 393 (41971 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SF-295 (48000 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-2 (46422 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-28 (48833 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-5 (47095 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-OV-3 (52876 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SN12C (47755 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SNB-19 (46794 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TK-10 (45540 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U-251 (51189 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UACC-257 (46019 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UACC-62 (47335 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UO-31 (46270 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
786-0 (47912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI/ADR-RES (33767 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
T47D (39041 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EKVX (44102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H322M (45589 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCC 2998 (41480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HOP-92 (41141 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hs-578T (29457 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H460 (60772 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SF-268 (49410 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IGROV-1 (47897 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LOX IMVI (44321 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HOP-62 (47048 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-435 (38290 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-N (28205 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Malme-3M (44254 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

dapA Dihydrodipicolinate synthase (65 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name pyrrolidine-2-carboxylic acid
INCHI InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)
InChi Key ONIBWKKTOPOVIA-UHFFFAOYSA-N
Canonical SMILES C1CC(NC1)C(=O)O
Isomeric SMILES C1CC(NC1)C(=O)O
PubChem CID 614
Molecular Weight 115.13(Monomer)

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

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4 results found

Lot NumberCertificate TypeDateItem
F23101195Certificate of AnalysisMay 17, 2023 P477766
F23101199Certificate of AnalysisMay 17, 2023 P477766
F23101200Certificate of AnalysisMay 17, 2023 P477766
F23101201Certificate of AnalysisMay 17, 2023 P477766

Chemical and Physical Properties

SolubilitySoluble in water (50 mg/ml), and acetic acid. Insoluble in DMF

Related Documents

Citations of This Product

1. Huiping Qi, Yanzhen Liu, Shi Shen, Jiafei Zhao.  (2023)  Green Polymer Poly-l-proline Efficiently Inhibits Formation of Gas Hydrates in Oil–Water System.  MACROMOLECULAR CHEMISTRY AND PHYSICS,  224  (23): (2300251).  [PMID:16227571] [10.1002/macp.202300251]

References

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2. M Rubert,M Monjo,S P Lyngstadaas,J M Ramis.  (2012-07-12)  Effect of alginate hydrogel containing polyproline-rich peptides on osteoblast differentiation..  Biomedical materials (Bristol, England),  ((5)): (055003-055003).  [PMID:22782012]
3. Charles W Bugg,J Mario Isas,Torsten Fischer,Paul H Patterson,Ralf Langen.  (2012-07-18)  Structural features and domain organization of huntingtin fibrils..  The Journal of biological chemistry,  287  ((38)): (31739-31746).  [PMID:22801429]
4. Noemi G Mirkin,Samuel Krimm.  (2012-07-19)  Water interaction differences determine the relative energetic stability of the polyproline II conformation of the alanine dipeptide in aqueous environments..  Biopolymers,  97  ((10)): (789-794).  [PMID:22806498]
5. Michael A Purdy.  (2012-07-20)  Evolution of the hepatitis E virus polyproline region: order from disorder..  Journal of virology,  86  ((18)): (10186-10193).  [PMID:22811526]
6. Kevser Biberoglu,Lawrence M Schopfer,Ozden Tacal,Oksana Lockridge.  (2012-08-15)  The proline-rich tetramerization peptides in equine serum butyrylcholinesterase..  The FEBS journal,  279  ((20)): (3844-3858).  [PMID:22889087]
7. Madhurima Das,Gautam Basu.  (2012-09-20)  Glycine rescue of β-sheets from cis-proline..  Journal of the American Chemical Society,  134  ((40)): (16536-16539).  [PMID:22989233]
8. M Ashtari,N M Cann.  (2012-10-17)  Poly-proline-based chiral stationary phases: a molecular dynamics study of triproline, tetraproline, pentaproline and hexaproline interfaces..  Journal of chromatography. A,  1265  (70-87).  [PMID:23068764]
9. Xing Zhang,Ryan R Julian.  (2012-11-01)  Photoinitiated intramolecular diradical cross-linking of polyproline peptides in the gas phase..  Physical chemistry chemical physics : PCCP,  14  ((47)): (16243-16249).  [PMID:23111659]
10. Nico J de Mol,John A W Kruijtzer,Ed E Moret,Isabelle Broutin,Rob M J Liskamp.  (2012-11-20)  Unusual binding of Grb2 protein to a bivalent polyproline-ligand immobilized on a SPR sensor: intermolecular bivalent binding..  Biochimica et biophysica acta,  1834  ((2)): (524-535).  [PMID:23159538]
11. Sonali B Rohamare,Vaishali Dixit,Pavan Kumar Nareddy,D Sivaramakrishna,Musti J Swamy,Sushama M Gaikwad.  (2012-12-29)  Polyproline fold-In imparting kinetic stability to an alkaline serine endopeptidase..  Biochimica et biophysica acta,  1834  ((3)): (708-716).  [PMID:23270996]
12. Stefania Conti,Giorgia Radicioni,Tecla Ciociola,Renato Longhi,Luciano Polonelli,Rita Gatti,Tiziana Cabras,Irene Messana,Massimo Castagnola,Alberto Vitali.  (2013-01-01)  Structural and functional studies on a proline-rich peptide isolated from swine saliva endowed with antifungal activity towards Cryptococcus neoformans..  Biochimica et biophysica acta,  1828  ((3)): (1066-1074).  [PMID:23274276]
13. W Austin Elam,Travis P Schrank,Andrew J Campagnolo,Vincent J Hilser.  (2013-01-24)  Evolutionary conservation of the polyproline II conformation surrounding intrinsically disordered phosphorylation sites..  Protein science : a publication of the Protein Society,  22  ((4)): (405-417).  [PMID:23341186]
14. W Austin Elam,Travis P Schrank,Andrew J Campagnolo,Vincent J Hilser.  (2013-01-29)  Temperature and urea have opposing impacts on polyproline II conformational bias..  Biochemistry,  52  ((5)): (949-958).  [PMID:23350874]
15. Kevser Biberoglu,Lawrence M Schopfer,Ashima Saxena,Ozden Tacal,Oksana Lockridge.  (2013-01-29)  Polyproline tetramer organizing peptides in fetal bovine serum acetylcholinesterase..  Biochimica et biophysica acta,  1834  ((4)): (745-753).  [PMID:23352838]
16. Alexander A Morgan,Edward Rubenstein.  (2013-02-02)  Proline: the distribution, frequency, positioning, and common functional roles of proline and polyproline sequences in the human proteome..  PloS one,  ((1)): (e53785-e53785).  [PMID:23372670]
17. Christopher J Woolstenhulme,Shankar Parajuli,David W Healey,Diana P Valverde,E Nicholas Petersen,Agata L Starosta,Nicholas R Guydosh,W Evan Johnson,Daniel N Wilson,Allen R Buskirk.  (2013-02-23)  Nascent peptides that block protein synthesis in bacteria..  Proceedings of the National Academy of Sciences of the United States of America,  110  ((10)): (E878-E887).  [PMID:23431150]
18. Alexei A Adzhubei,Michael J E Sternberg,Alexander A Makarov.  (2013-03-20)  Polyproline-II helix in proteins: structure and function..  Journal of molecular biology,  425  ((12)): (2100-2132).  [PMID:23507311]
19. Robert W Newberry,Ronald T Raines.  (2013-07-31)  n→π* interactions in poly(lactic acid) suggest a role in protein folding..  Chemical communications (Cambridge, England),  49  ((70)): (7699-7701).  [PMID:23897514]
20. Nicholas Stephane Caron,Carly Robyn Desmond,Jianrun Xia,Ray Truant.  (2013-07-31)  Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin..  Proceedings of the National Academy of Sciences of the United States of America,  110  ((36)): (14610-14615).  [PMID:23898200]
21. Sebastien Lhomme,Cyril Garrouste,Nassim Kamar,Karine Saune,Florence Abravanel,Jean-Michel Mansuy,Martine Dubois,Lionel Rostaing,Jacques Izopet.  (2013-08-22)  Influence of polyproline region and macro domain genetic heterogeneity on HEV persistence in immunocompromised patients..  The Journal of infectious diseases,  209  ((2)): (300-303).  [PMID:23964111]
22. Sebastien Lhomme,Florence Abravanel,Martine Dubois,Karine Sandres-Saune,Jean-Michel Mansuy,Lionel Rostaing,Nassim Kamar,Jacques Izopet.  (2014-08-08)  Characterization of the polyproline region of the hepatitis E virus in immunocompromised patients..  Journal of virology,  88  ((20)): (12017-12025).  [PMID:25100839]
23. Lucía B Chemes,Leonardo G Alonso,María G Noval,Gonzalo de Prat-Gay.  (2012-07-05)  Circular dichroism techniques for the analysis of intrinsically disordered proteins and domains..  Methods in molecular biology (Clifton, N.J.),  895  (387-404).  [PMID:22760329]
24. Conor C G Scully,Vishal Rai,Gennadiy Poda,Serge Zaretsky,Darcy C Burns,R Scott Houliston,Tiantong Lou,Andrei K Yudin.  (2012-11-06)  Bending rigid molecular rods: formation of oligoproline macrocycles..  Chemistry (Weinheim an der Bergstrasse, Germany),  18  ((49)): (15612-15617).  [PMID:23124621]
25. Manuel E Patarroyo,Armando Moreno-Vranich,Adriana Bermúdez.  (2012-11-13)  Phi (Φ) and psi (Ψ) angles involved in malarial peptide bonds determine sterile protective immunity..  Biochemical and biophysical research communications,  429  ((1-2)): (75-80).  [PMID:23142598]
26. Susanne Ude,Jürgen Lassak,Agata L Starosta,Tobias Kraxenberger,Daniel N Wilson,Kirsten Jung.  (2012-12-15)  Translation elongation factor EF-P alleviates ribosome stalling at polyproline stretches..  Science (New York, N.Y.),  339  ((6115)): (82-85).  [PMID:23239623]
27. Allen R Buskirk,Rachel Green.  (2013-01-05)  Biochemistry. Getting past polyproline pauses..  Science (New York, N.Y.),  339  ((6115)): (38-39).  [PMID:23288527]
28. Emmanuel B Naziga,Frank Schweizer,Stacey D Wetmore.  (2013-02-01)  Solvent interactions stabilize the polyproline II conformation of glycosylated oligoprolines..  The journal of physical chemistry. B,  117  ((9)): (2671-2681).  [PMID:23363073]
29. Yolanda Pérez,Mariano Maffei,Ana Igea,Irene Amata,Margarida Gairí,Angel R Nebreda,Pau Bernadó,Miquel Pons.  (2013-02-19)  Lipid binding by the Unique and SH3 domains of c-Src suggests a new regulatory mechanism..  Scientific reports,  (1295-1295).  [PMID:23416516]
30. Siobhan Toal,Derya Meral,Daniel Verbaro,Brigita Urbanc,Reinhard Schweitzer-Stenner.  (2013-03-02)  pH-Independence of trialanine and the effects of termini blocking in short peptides: a combined vibrational, NMR, UVCD, and molecular dynamics study..  The journal of physical chemistry. B,  117  ((14)): (3689-3706).  [PMID:23448349]
31. Huiping Qi, Yanzhen Liu, Shi Shen, Jiafei Zhao.  (2023)  Green Polymer Poly-l-proline Efficiently Inhibits Formation of Gas Hydrates in Oil–Water System.  MACROMOLECULAR CHEMISTRY AND PHYSICS,  224  (23): (2300251).  [PMID:16227571] [10.1002/macp.202300251]

Solution Calculators