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Poly-L-proline - mol wt 1,000-10,000, high purity , CAS No.25191-13-3

1 Citations

mol wt 1,000-10,000

CAS#: 25191-13-3
Formula: (C₅H₇NO)n
Molecular Weight: 115.13(Monomer)
MDL number: MFCD00166364
PubChem CID: 614

Item Number

P477776

Grouped product items
SKU	Size	Availability	Price	Qty
P477776-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$800.90
P477776-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,434.90

View related series

Amino acids

Basic Description

Synonyms	L-Proline homopolymer
Specifications & Purity	mol wt 1,000-10,000
Biochemical and Physiological Mechanisms	Poly-L-Proline is an antigenic homopolymer.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

RUNX1 Tbio Runt-related transcription factor 1 (0 Activities)

Discover Target: RUNX1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLK Tbio DNA polymerase kappa (0 Activities)

Discover Target: POLK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN1 Tclin Glutamate receptor ionotropic, NMDA 1 (0 Activities)

Discover Target: GRIN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 Activities)

Discover Target: GRIN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A498 (42825 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACHN (49357 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

COLO 205 (50209 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DU-145 (51482 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HL-60 (67320 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HT-29 (80576 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

K562 (73714 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KM12 (47707 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

M14 (47487 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MCF7 (126967 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MOLT-4 (49676 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OVCAR-3 (48710 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OVCAR-4 (44535 Activities)

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OVCAR-5 (45555 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OVCAR-8 (47708 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PC-3 (62116 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RPMI-8226 (44974 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RXF 393 (41971 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SF-295 (48000 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SK-MEL-2 (46422 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SK-MEL-28 (48833 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SK-MEL-5 (47095 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SK-OV-3 (52876 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SN12C (47755 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SNB-19 (46794 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TK-10 (45540 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U-251 (51189 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UACC-257 (46019 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UACC-62 (47335 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UO-31 (46270 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

786-0 (47912 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A549 (127892 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NCI/ADR-RES (33767 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

T47D (39041 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EKVX (44102 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NCI-H322M (45589 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HCC 2998 (41480 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HCT-116 (91556 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HOP-92 (41141 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hs-578T (29457 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NCI-H460 (60772 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SF-268 (49410 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IGROV-1 (47897 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LOX IMVI (44321 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HOP-62 (47048 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDA-MB-435 (38290 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDA-N (28205 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Malme-3M (44254 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDA-MB-231 (73002 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

dapA Dihydrodipicolinate synthase (65 Activities)

Discover Target: dapA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

Discover Target: ffp

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	pyrrolidine-2-carboxylic acid
INCHI	InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)
InChi Key	ONIBWKKTOPOVIA-UHFFFAOYSA-N
Canonical SMILES	C1CC(NC1)C(=O)O
Isomeric SMILES	C1CC(NC1)C(=O)O
PubChem CID	614
Molecular Weight	115.13(Monomer)

Certificates

Certificate of Analysis(COA)

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3 results found

Lot Number	Certificate Type	Date	Item
D2419437	Certificate of Analysis	Apr 11, 2024	P477776
D2419438	Certificate of Analysis	Apr 11, 2024	P477776
D2419439	Certificate of Analysis	Apr 11, 2024	P477776

Alternative Products

Citations of This Product

1. Huiping Qi, Yanzhen Liu, Shi Shen, Jiafei Zhao. (2023) Green Polymer Poly-l-proline Efficiently Inhibits Formation of Gas Hydrates in Oil–Water System. MACROMOLECULAR CHEMISTRY AND PHYSICS, 224 (23): (2300251). [PMID:16227571]

References

1. Manos Gkikas,Hermis Iatrou,Nikolaos S Thomaidis,Paschalis Alexandridis,Nikos Hadjichristidis. (2011-05-17) Well-defined homopolypeptides, copolypeptides, and hybrids of poly(l-proline).. Biomacromolecules, 12 ((6)): (2396-2406). [PMID:21568310]
2. M Rubert,M Monjo,S P Lyngstadaas,J M Ramis. (2012-07-12) Effect of alginate hydrogel containing polyproline-rich peptides on osteoblast differentiation.. Biomedical materials (Bristol, England), 7 ((5)): (055003-055003). [PMID:22782012]
3. Charles W Bugg,J Mario Isas,Torsten Fischer,Paul H Patterson,Ralf Langen. (2012-07-18) Structural features and domain organization of huntingtin fibrils.. The Journal of biological chemistry, 287 ((38)): (31739-31746). [PMID:22801429]
4. Noemi G Mirkin,Samuel Krimm. (2012-07-19) Water interaction differences determine the relative energetic stability of the polyproline II conformation of the alanine dipeptide in aqueous environments.. Biopolymers, 97 ((10)): (789-794). [PMID:22806498]
5. Michael A Purdy. (2012-07-20) Evolution of the hepatitis E virus polyproline region: order from disorder.. Journal of virology, 86 ((18)): (10186-10193). [PMID:22811526]
6. Kevser Biberoglu,Lawrence M Schopfer,Ozden Tacal,Oksana Lockridge. (2012-08-15) The proline-rich tetramerization peptides in equine serum butyrylcholinesterase.. The FEBS journal, 279 ((20)): (3844-3858). [PMID:22889087]
7. Madhurima Das,Gautam Basu. (2012-09-20) Glycine rescue of β-sheets from cis-proline.. Journal of the American Chemical Society, 134 ((40)): (16536-16539). [PMID:22989233]
8. Xing Zhang,Ryan R Julian. (2012-11-01) Photoinitiated intramolecular diradical cross-linking of polyproline peptides in the gas phase.. Physical chemistry chemical physics : PCCP, 14 ((47)): (16243-16249). [PMID:23111659]
9. Nico J de Mol,John A W Kruijtzer,Ed E Moret,Isabelle Broutin,Rob M J Liskamp. (2012-11-20) Unusual binding of Grb2 protein to a bivalent polyproline-ligand immobilized on a SPR sensor: intermolecular bivalent binding.. Biochimica et biophysica acta, 1834 ((2)): (524-535). [PMID:23159538]
10. Sonali B Rohamare,Vaishali Dixit,Pavan Kumar Nareddy,D Sivaramakrishna,Musti J Swamy,Sushama M Gaikwad. (2012-12-29) Polyproline fold-In imparting kinetic stability to an alkaline serine endopeptidase.. Biochimica et biophysica acta, 1834 ((3)): (708-716). [PMID:23270996]
11. Stefania Conti,Giorgia Radicioni,Tecla Ciociola,Renato Longhi,Luciano Polonelli,Rita Gatti,Tiziana Cabras,Irene Messana,Massimo Castagnola,Alberto Vitali. (2013-01-01) Structural and functional studies on a proline-rich peptide isolated from swine saliva endowed with antifungal activity towards Cryptococcus neoformans.. Biochimica et biophysica acta, 1828 ((3)): (1066-1074). [PMID:23274276]
12. W Austin Elam,Travis P Schrank,Andrew J Campagnolo,Vincent J Hilser. (2013-01-24) Evolutionary conservation of the polyproline II conformation surrounding intrinsically disordered phosphorylation sites.. Protein science : a publication of the Protein Society, 22 ((4)): (405-417). [PMID:23341186]
13. W Austin Elam,Travis P Schrank,Andrew J Campagnolo,Vincent J Hilser. (2013-01-29) Temperature and urea have opposing impacts on polyproline II conformational bias.. Biochemistry, 52 ((5)): (949-958). [PMID:23350874]
14. Kevser Biberoglu,Lawrence M Schopfer,Ashima Saxena,Ozden Tacal,Oksana Lockridge. (2013-01-29) Polyproline tetramer organizing peptides in fetal bovine serum acetylcholinesterase.. Biochimica et biophysica acta, 1834 ((4)): (745-753). [PMID:23352838]
15. Alexander A Morgan,Edward Rubenstein. (2013-02-02) Proline: the distribution, frequency, positioning, and common functional roles of proline and polyproline sequences in the human proteome.. PloS one, 8 ((1)): (e53785-e53785). [PMID:23372670]
16. Christopher J Woolstenhulme,Shankar Parajuli,David W Healey,Diana P Valverde,E Nicholas Petersen,Agata L Starosta,Nicholas R Guydosh,W Evan Johnson,Daniel N Wilson,Allen R Buskirk. (2013-02-23) Nascent peptides that block protein synthesis in bacteria.. Proceedings of the National Academy of Sciences of the United States of America, 110 ((10)): (E878-E887). [PMID:23431150]
17. Alexei A Adzhubei,Michael J E Sternberg,Alexander A Makarov. (2013-03-20) Polyproline-II helix in proteins: structure and function.. Journal of molecular biology, 425 ((12)): (2100-2132). [PMID:23507311]
18. Robert W Newberry,Ronald T Raines. (2013-07-31) n→π* interactions in poly(lactic acid) suggest a role in protein folding.. Chemical communications (Cambridge, England), 49 ((70)): (7699-7701). [PMID:23897514]
19. Nicholas Stephane Caron,Carly Robyn Desmond,Jianrun Xia,Ray Truant. (2013-07-31) Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin.. Proceedings of the National Academy of Sciences of the United States of America, 110 ((36)): (14610-14615). [PMID:23898200]
20. Sebastien Lhomme,Cyril Garrouste,Nassim Kamar,Karine Saune,Florence Abravanel,Jean-Michel Mansuy,Martine Dubois,Lionel Rostaing,Jacques Izopet. (2013-08-22) Influence of polyproline region and macro domain genetic heterogeneity on HEV persistence in immunocompromised patients.. The Journal of infectious diseases, 209 ((2)): (300-303). [PMID:23964111]
21. Sebastien Lhomme,Florence Abravanel,Martine Dubois,Karine Sandres-Saune,Jean-Michel Mansuy,Lionel Rostaing,Nassim Kamar,Jacques Izopet. (2014-08-08) Characterization of the polyproline region of the hepatitis E virus in immunocompromised patients.. Journal of virology, 88 ((20)): (12017-12025). [PMID:25100839]
22. Edoardo Del Poggetto,Fabrizio Chiti,Francesco Bemporad. (2015-08-01) The Folding process of Human Profilin-1, a novel protein associated with familial amyotrophic lateral sclerosis.. Scientific reports, 5 (12332-12332). [PMID:26227615]
23. Lucía B Chemes,Leonardo G Alonso,María G Noval,Gonzalo de Prat-Gay. (2012-07-05) Circular dichroism techniques for the analysis of intrinsically disordered proteins and domains.. Methods in molecular biology (Clifton, N.J.), 895 (387-404). [PMID:22760329]
24. Conor C G Scully,Vishal Rai,Gennadiy Poda,Serge Zaretsky,Darcy C Burns,R Scott Houliston,Tiantong Lou,Andrei K Yudin. (2012-11-06) Bending rigid molecular rods: formation of oligoproline macrocycles.. Chemistry (Weinheim an der Bergstrasse, Germany), 18 ((49)): (15612-15617). [PMID:23124621]
25. Manuel E Patarroyo,Armando Moreno-Vranich,Adriana Bermúdez. (2012-11-13) Phi (Φ) and psi (Ψ) angles involved in malarial peptide bonds determine sterile protective immunity.. Biochemical and biophysical research communications, 429 ((1-2)): (75-80). [PMID:23142598]
26. Susanne Ude,Jürgen Lassak,Agata L Starosta,Tobias Kraxenberger,Daniel N Wilson,Kirsten Jung. (2012-12-15) Translation elongation factor EF-P alleviates ribosome stalling at polyproline stretches.. Science (New York, N.Y.), 339 ((6115)): (82-85). [PMID:23239623]
27. Allen R Buskirk,Rachel Green. (2013-01-05) Biochemistry. Getting past polyproline pauses.. Science (New York, N.Y.), 339 ((6115)): (38-39). [PMID:23288527]
28. Emmanuel B Naziga,Frank Schweizer,Stacey D Wetmore. (2013-02-01) Solvent interactions stabilize the polyproline II conformation of glycosylated oligoprolines.. The journal of physical chemistry. B, 117 ((9)): (2671-2681). [PMID:23363073]
29. Yolanda Pérez,Mariano Maffei,Ana Igea,Irene Amata,Margarida Gairí,Angel R Nebreda,Pau Bernadó,Miquel Pons. (2013-02-19) Lipid binding by the Unique and SH3 domains of c-Src suggests a new regulatory mechanism.. Scientific reports, 3 (1295-1295). [PMID:23416516]
30. Siobhan Toal,Derya Meral,Daniel Verbaro,Brigita Urbanc,Reinhard Schweitzer-Stenner. (2013-03-02) pH-Independence of trialanine and the effects of termini blocking in short peptides: a combined vibrational, NMR, UVCD, and molecular dynamics study.. The journal of physical chemistry. B, 117 ((14)): (3689-3706). [PMID:23448349]
31. Bindu Ambaru,Anupriya Gopalsamy,T V Satish Tammana,Hosahalli S Subramanya,Chhitar M Gupta. (2020-05-15) Actin sequestering protein, profilin, regulates intracellular vesicle transport in Leishmania.. Molecular and biochemical parasitology, 238 (111280-111280). [PMID:32407750]
32. M Ashtari,N M Cann. (2012-10-17) Poly-proline-based chiral stationary phases: a molecular dynamics study of triproline, tetraproline, pentaproline and hexaproline interfaces.. Journal of chromatography. A, 1265 (70-87). [PMID:23068764]
33. Huiping Qi, Yanzhen Liu, Shi Shen, Jiafei Zhao. (2023) Green Polymer Poly-l-proline Efficiently Inhibits Formation of Gas Hydrates in Oil–Water System. MACROMOLECULAR CHEMISTRY AND PHYSICS, 224 (23): (2300251). [PMID:16227571]

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