Polyglutamine Aggregation Inhibitor, PGL-135 , CAS No.26278-83-1

Item Number

P346100

Grouped product items
SKU	Size	Availability	Price	Qty
P346100-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$95.90

a benzothiazole polyQ-aggregation inhibitor

Basic Description

Synonyms	PGL-135 \| APU56YKT8N \| SCHEMBL1266791 \| 2-Amino-4,7-dimethylbenzo[d]thiazol-6-ol \| 6-Benzothiazolol, 2-amino-4,7-dimethyl- \| NCGC00165866-01 \| UNII-APU56YKT8N \| 2-Amino-4,7-dimethyl-6-benzothiazolol \| 2-amino-6-hydroxy-4,7-dimethylbenzothiazole \| 2-amino-
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Product Description	Polyglutamine Aggregation Inhibitor, PGL-135 is a cell-permeable benzothiazole compound that binds to polyglutamine (PQBP-1, polyQ)-containing β-sheet structures and prevents polyQ-aggregation, a pathological hallmark of Huntington's disease (HD) and related glutamine repeat disorders. Shown to be non-toxic and prevent HDQ51 (FLAG\|?\|-tag HD exon 1 protein with 51 glutamines)-aggregation in 293 Tet-Off (293 tetracycline-off) cells with an IC\|50\|of ~ 40 λμM.

Associated Targets(non-human)

GCN5 Histone acetyltransferase GCN5 (89 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Danio rerio (3092 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	2-amino-4,7-dimethyl-1,3-benzothiazol-6-ol
INCHI	InChI=1S/C9H10N2OS/c1-4-3-6(12)5(2)8-7(4)11-9(10)13-8/h3,12H,1-2H3,(H2,10,11)
InChi Key	RUTNKAMSWIPHJW-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=C(C2=C1N=C(S2)N)C)O
Isomeric SMILES	CC1=CC(=C(C2=C1N=C(S2)N)C)O
PubChem CID	9855723
Molecular Weight	230.7

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Basic Description