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Polyglutamine Aggregation Inhibitor, PGL-135 , CAS No.26278-83-1
a benzothiazole polyQ-aggregation inhibitor
Basic Description Synonyms PGL-135 | APU56YKT8N | SCHEMBL1266791 | 2-Amino-4,7-dimethylbenzo[d]thiazol-6-ol | 6-Benzothiazolol, 2-amino-4,7-dimethyl- | NCGC00165866-01 | UNII-APU56YKT8N | 2-Amino-4,7-dimethyl-6-benzothiazolol | 2-amino-6-hydroxy-4,7-dimethylbenzothiazole | 2-amino- Storage Temp Store at 2-8°C Shipped In Wet ice Product Description Polyglutamine Aggregation Inhibitor, PGL-135 is a cell-permeable benzothiazole compound that binds to polyglutamine (PQBP-1, polyQ)-containing β-sheet structures and prevents polyQ-aggregation, a pathological hallmark of Huntington's disease (HD) and related glutamine repeat disorders. Shown to be non-toxic and prevent HDQ51 (FLAG|?|-tag HD exon 1 protein with 51 glutamines)-aggregation in 293 Tet-Off (293 tetracycline-off) cells with an IC|50|of ~ 40 λμM.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 2-amino-4,7-dimethyl-1,3-benzothiazol-6-ol INCHI InChI=1S/C9H10N2OS/c1-4-3-6(12)5(2)8-7(4)11-9(10)13-8/h3,12H,1-2H3,(H2,10,11) InChi Key RUTNKAMSWIPHJW-UHFFFAOYSA-N Canonical SMILES CC1=CC(=C(C2=C1N=C(S2)N)C)O Isomeric SMILES CC1=CC(=C(C2=C1N=C(S2)N)C)O PubChem CID 9855723 Molecular Weight 230.7
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