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Polygodial - ≥97%, high purity , CAS No.6754-20-7, Activator of TRPA1

Item Number

P274659

Grouped product items
SKU	Size	Availability	Price	Qty
P274659-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$150.90
P274659-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$675.90

Selective TRPA1 agonist. Antifungal.

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Basic Description

Synonyms	6754-20-7\|Tadeonal\|Poligodial\|Drim-7-ene-11,12-dial\|(-)-Tadeonal\|Tadeodal\|(1R,4aS,8aS)-5,5,8a-trimethyl-1,4,4a,6,7,8-hexahydronaphthalene-1,2-dicarbaldehyde\|(1r,4as,8as)-5,5,8a-trimethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalene-1,2-dicarbaldehyde\|5FAF7T66M7
Specifications & Purity	≥97%
Storage Temp	Store at -20°C,Desiccated
Shipped In	Dry ice
Grade	Moligand™
Action Type	ACTIVATOR
Mechanism of action	Activator of TRPA1
Product Description	Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	(1R,4aS,8aS)-5,5,8a-trimethyl-1,4,4a,6,7,8-hexahydronaphthalene-1,2-dicarbaldehyde
INCHI	InChI=1S/C15H22O2/c1-14(2)7-4-8-15(3)12(10-17)11(9-16)5-6-13(14)15/h5,9-10,12-13H,4,6-8H2,1-3H3/t12-,13-,15+/m0/s1
InChi Key	AZJUJOFIHHNCSV-KCQAQPDRSA-N
Canonical SMILES	CC1(CCCC2(C1CC=C(C2C=O)C=O)C)C
Isomeric SMILES	C[C@]12CCCC([C@@H]1CC=C([C@@H]2C=O)C=O)(C)C
Alternate CAS	6754-20-7,33118-34-2,6754-20-7
PubChem CID	72503
NSC Number	372407
MeSH Entry Terms	1,4,4a,5,6,7,8,8a-octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde;epipolygodial;polygodial
Molecular Weight	234.3

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Solubility	Soluble in DMSO to 100 mM and in ethanol to 100 mM

1. Escalera J, von Hehn CA, Bessac BF, Sivula M, Jordt SE. (2008) TRPA1 mediates the noxious effects of natural sesquiterpene deterrents.. J Biol Chem, 283 (35): (24136-44). [PMID:18550530]

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