Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P274659-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $150.90 | |
P274659-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $675.90 |
Selective TRPA1 agonist. Antifungal.
Synonyms | 1,2-Naphthalenedicarboxaldehyde,1,4,4a,5,6,7,8,8a-octahydro-5,5,8a-trimethyl-, (1R,4aS,8aS)- | A00RAV0W57 | Tadeonal | UNII-5FAF7T66M7 | BDBM50318479 | GTPL10293 | HY-108450 | 1,2-NAPHTHALENEDICARBOXALDEHYDE, 1,4,4A,5,6,7,8,8A-OCTAHYDRO-5,5,8A-TRIMETHYL-, |
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Specifications & Purity | Moligand™, ≥97% |
Biochemical and Physiological Mechanisms | Selective TRPA1 agonist (EC 50 = 400 nM). Antinociceptive in vivo. Inhibits mitochondrial ATPase (IC 50 = 15 μM). Antifungal. |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ACTIVATOR |
Mechanism of action | Activator of TRPA1 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (1R,4aS,8aS)-5,5,8a-trimethyl-1,4,4a,6,7,8-hexahydronaphthalene-1,2-dicarbaldehyde |
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INCHI | InChI=1S/C15H22O2/c1-14(2)7-4-8-15(3)12(10-17)11(9-16)5-6-13(14)15/h5,9-10,12-13H,4,6-8H2,1-3H3/t12-,13-,15+/m0/s1 |
InChi Key | AZJUJOFIHHNCSV-KCQAQPDRSA-N |
Canonical SMILES | CC1(CCCC2(C1CC=C(C2C=O)C=O)C)C |
Isomeric SMILES | C[C@]12CCCC([C@@H]1CC=C([C@@H]2C=O)C=O)(C)C |
Alternate CAS | 6754-20-7,33118-34-2,6754-20-7 |
PubChem CID | 72503 |
NSC Number | 372407 |
MeSH Entry Terms | 1,4,4a,5,6,7,8,8a-octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde;epipolygodial;polygodial |
Molecular Weight | 234.3 |
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Solubility | Soluble in DMSO to 100 mM and in ethanol to 100 mM |
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1. Escalera J, von Hehn CA, Bessac BF, Sivula M, Jordt SE. (2008) TRPA1 mediates the noxious effects of natural sesquiterpene deterrents.. J Biol Chem, 283 (35): (24136-44). [PMID:18550530] [10.1021/op500134e] |